| Interacting proteins: Q15942 and Q14847 |
Pubmed |
SVM Score :0.73796871 |
| Overlay studies demonstrate that LASP 1 directly binds to the proline rich domains of zyxin , lipoma preferred partner ( LPP ) , and vasodilator stimulated phosphoprotein ( VASP ) , with zyxin being the most prominent interacting partner . 0.73796871^^^ |
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| Interacting proteins: Q15942 and Q14847 |
Pubmed |
SVM Score :0.0 |
| Silencing of LASP 1 influences zyxin localization , inhibits proliferation and reduces migration in breast cancer cells . ^^^ LASP 1 is an actin binding protein , which also interacts with the proline rich domains of zyxin , a scaffolding protein required for cell movement and gene transcription . ^^^ LASP 1 silencing is accompanied with a reduced binding of the of LASP 1 binding partner zyxin to focal contacts without changes in actin stress fiber organization as observed in immunofluorescence experiments . ^^^ The data provide evidence for an essential role of LASP 1 in tumor cell growth and migration , possibly by influencing the localization of zyxin . . ^^^ |
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