| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| The vault complex is a ubiquitous 13 MDa ribonucleoprotein assembly , composed of three proteins ( TEP 1 , 240 kDa ; VPARP , 193 kDa ; and MVP , 100 kDa ) that are highly conserved in eukaryotes and an untranslated RNA ( vRNA ) . ^^^ The molecular architecture of the complex is emerging , with 96 copies of MVP composing the eightfold symmetric barrel , and the vRNA together with one copy of TEP 1 and four predicted copies of VPARP comprising each cap . . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| Vaults are ribonucleoprotein complexes comprised of the 100 kDa major vault protein ( MVP ) , the 2 high m . w . vault proteins p 193 ( VPARP ) and p 240 ( TEP 1 ) and an untranslated small RNA ( vRNA ) . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| The complex consists of a major vault protein ( MVP ) , two minor vault proteins ( VPARP and TEP 1 ) , and several small untranslated RNA molecules . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| Vaults consist of multiple copies of three proteins ( MVP , VPARP , and TEP 1 ) and several untranslated RNAs . ^^^ However , the N terminal half of MVP binds to a specific domain in the C terminus of VPARP . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| Vaults are barrel shaped cytoplasmic ribonucleoprotein particles that are composed of a major vault protein ( MVP ) , two minor vault proteins [ telomerase associated protein 1 ( TEP 1 ) , vault poly ( ADP ribose ) polymerase ( VPARP ) ] and small untranslated RNA molecules . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| The 13 MDa particles are composed of multiple copies of three proteins : an M ( r ) 100 000 major vault protein ( MVP ) and two minor vault proteins of M ( r ) 193 000 ( vault poly ( ADP ribose ) polymerase ) and M ( r ) 240 000 ( telomerase associated protein 1 ) , as well as small untranslated RNA molecules of approximately 100 bases . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP . ^^^ To further understand vault component up regulation , the three proteins that comprise the vault , the major vault protein ( MVP ) , vault poly ( ADP ribose ) polymerase ( VPARP ) , and telomerase associated protein 1 ( TEP 1 ) , were examined with respect to gene amplification and drug induced chromatin remodeling . ^^^ The TATA less murine MVP and human VPARP promoters were identified and functionally characterized . ^^^ There was no significant activation of either the MVP or VPARP promoters in drug resistant cell lines in comparison to their parental , drug sensitive counterparts . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| Cryoelectron microscopy imaging of recombinant and tissue derived vaults : localization of the MVP N termini and VPARP . ^^^ It has a barrel shaped structure and is composed of the major vault protein ( MVP ) ; vault poly ( ADP ribose ) polymerase ( VPARP ) ; telomerase associated protein 1 ( TEP 1 ) ; and small untranslated RNA ( vRNA ) . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes . ^^^ Vaults are barrel shaped cytoplasmic ribonucleoprotein particles composed of three proteins : the major vault protein ( MVP ) , the vault poly ( ADP ribose ) polymerase ( VPARP ) , and the telomerase associated protein 1 , together with one or more small untranslated RNAs . ^^^ In this study , we analyzed the biosynthesis of MVP and VPARP , and their half lives within the vault particle in human ACHN renal carcinoma cells . ^^^ Once incorporated into the vault complex , both MVP and VPARP were very stable . ^^^ The C terminal region of VPARP that lacks poly ( ADP ribose ) polymerase activity co sedimented with MVP particles . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| Chemical shift perturbation studies identified the binding site of vault poly ( ADP ribose ) polymerase , another component of vault particles , indicating that MVP domains form a new class of interaction mediating modules . . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| For the three protein species ( TEP 1 , VPARP , and MVP ) and a small RNA that comprises vault , expression of the unique 100 kDa major vault protein ( MVP ) is sufficient to form the basic vault structure . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| The main component of vaults represents the 110 kDa major vault protein ( MVP ) , whereas the two minor vault proteins comprise the 193 kDa vault poly ( ADP ribose ) polymerase ( VPARP ) and the 240 kDa telomerase associated protein 1 ( TEP 1 ) . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , we found that VPARP and TEP 1 are able to incorporate into vaults even after the formation of the MVP vault particle shell is complete . ^^^ |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and Q9UKK3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| Vaults are barrel shaped cytoplasmic ribonucleoprotein particles that are composed of a major vault protein ( MVP ) , two minor vault proteins [ telomerase associated protein 1 ( TEP 1 ) , vault poly ( ADP ribose ) polymerase ( VPARP ) ] and small untranslated RNA molecules . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| The 13 MDa particles are composed of multiple copies of three proteins : an M ( r ) 100 000 major vault protein ( MVP ) and two minor vault proteins of M ( r ) 193 000 ( vault poly ( ADP ribose ) polymerase ) and M ( r ) 240 000 ( telomerase associated protein 1 ) , as well as small untranslated RNA molecules of approximately 100 bases . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| To further understand vault component up regulation , the three proteins that comprise the vault , the major vault protein ( MVP ) , vault poly ( ADP ribose ) polymerase ( VPARP ) , and telomerase associated protein 1 ( TEP 1 ) , were examined with respect to gene amplification and drug induced chromatin remodeling . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| It has a barrel shaped structure and is composed of the major vault protein ( MVP ) ; vault poly ( ADP ribose ) polymerase ( VPARP ) ; telomerase associated protein 1 ( TEP 1 ) ; and small untranslated RNA ( vRNA ) . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| Vaults are barrel shaped cytoplasmic ribonucleoprotein particles composed of three proteins : the major vault protein ( MVP ) , the vault poly ( ADP ribose ) polymerase ( VPARP ) , and the telomerase associated protein 1 , together with one or more small untranslated RNAs . ^^^ The C terminal region of VPARP that lacks poly ( ADP ribose ) polymerase activity co sedimented with MVP particles . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| Chemical shift perturbation studies identified the binding site of vault poly ( ADP ribose ) polymerase , another component of vault particles , indicating that MVP domains form a new class of interaction mediating modules . . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| The main component of vaults represents the 110 kDa major vault protein ( MVP ) , whereas the two minor vault proteins comprise the 193 kDa vault poly ( ADP ribose ) polymerase ( VPARP ) and the 240 kDa telomerase associated protein 1 ( TEP 1 ) . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| The vault complex is a ubiquitous 13 MDa ribonucleoprotein assembly , composed of three proteins ( TEP 1 , 240 kDa ; VPARP , 193 kDa ; and MVP , 100 kDa ) that are highly conserved in eukaryotes and an untranslated RNA ( vRNA ) . ^^^ The molecular architecture of the complex is emerging , with 96 copies of MVP composing the eightfold symmetric barrel , and the vRNA together with one copy of TEP 1 and four predicted copies of VPARP comprising each cap . . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| Vaults are ribonucleoprotein complexes comprised of the 100 kDa major vault protein ( MVP ) , the 2 high m . w . vault proteins p 193 ( VPARP ) and p 240 ( TEP 1 ) and an untranslated small RNA ( vRNA ) . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| The complex consists of a major vault protein ( MVP ) , two minor vault proteins ( VPARP and TEP 1 ) , and several small untranslated RNA molecules . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| Vaults consist of multiple copies of three proteins ( MVP , VPARP , and TEP 1 ) and several untranslated RNAs . ^^^ However , the N terminal half of MVP binds to a specific domain in the C terminus of VPARP . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| For the three protein species ( TEP 1 , VPARP , and MVP ) and a small RNA that comprises vault , expression of the unique 100 kDa major vault protein ( MVP ) is sufficient to form the basic vault structure . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , we found that VPARP and TEP 1 are able to incorporate into vaults even after the formation of the MVP vault particle shell is complete . ^^^ |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKK3 and Q14764 |
Pubmed |
SVM Score :0.0 |
| NA |
|