| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.57355237 |
| Difference maps designed to localize TEP 1 showed only weak density inside of the caps , suggesting that TEP 1 may interact with MVP via a small interaction region . 0.57355237^^^ |
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| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| The vault complex is a ubiquitous 13 MDa ribonucleoprotein assembly , composed of three proteins ( TEP 1 , 240 kDa ; VPARP , 193 kDa ; and MVP , 100 kDa ) that are highly conserved in eukaryotes and an untranslated RNA ( vRNA ) . ^^^ The molecular architecture of the complex is emerging , with 96 copies of MVP composing the eightfold symmetric barrel , and the vRNA together with one copy of TEP 1 and four predicted copies of VPARP comprising each cap . . ^^^ |
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| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| Vaults are ribonucleoprotein complexes comprised of the 100 kDa major vault protein ( MVP ) , the 2 high m . w . vault proteins p 193 ( VPARP ) and p 240 ( TEP 1 ) and an untranslated small RNA ( vRNA ) . ^^^ |
|
| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| The complex consists of a major vault protein ( MVP ) , two minor vault proteins ( VPARP and TEP 1 ) , and several small untranslated RNA molecules . ^^^ |
|
| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| Vaults consist of multiple copies of three proteins ( MVP , VPARP , and TEP 1 ) and several untranslated RNAs . ^^^ |
|
| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| Vaults are barrel shaped cytoplasmic ribonucleoprotein particles that are composed of a major vault protein ( MVP ) , two minor vault proteins [ telomerase associated protein 1 ( TEP 1 ) , vault poly ( ADP ribose ) polymerase ( VPARP ) ] and small untranslated RNA molecules . ^^^ |
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| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| To further understand vault component up regulation , the three proteins that comprise the vault , the major vault protein ( MVP ) , vault poly ( ADP ribose ) polymerase ( VPARP ) , and telomerase associated protein 1 ( TEP 1 ) , were examined with respect to gene amplification and drug induced chromatin remodeling . ^^^ |
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| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| For the three protein species ( TEP 1 , VPARP , and MVP ) and a small RNA that comprises vault , expression of the unique 100 kDa major vault protein ( MVP ) is sufficient to form the basic vault structure . ^^^ |
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| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| The main component of vaults represents the 110 kDa major vault protein ( MVP ) , whereas the two minor vault proteins comprise the 193 kDa vault poly ( ADP ribose ) polymerase ( VPARP ) and the 240 kDa telomerase associated protein 1 ( TEP 1 ) . ^^^ |
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| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , we found that VPARP and TEP 1 are able to incorporate into vaults even after the formation of the MVP vault particle shell is complete . ^^^ |
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| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| Evaluation of MDR 1 , LRP , MRP , and topoisomerase IIalpha gene mRNA transcripts before and after interferon alpha , and correlation with the mRNA expression level of the telomerase subunits hTERT and TEP 1 in five unselected human melanoma cell lines . ^^^ We investigated the expression of the multidrug resistance ( MDR 1 ) gene , multidrug resistance protein ( MRP ) , lung resistance protein ( LRP ) , topoisomerase IIalpha ( Topo IIalpha ) , hTERT , and telomerase associated protein ( TEP 1 ) , which is shared by telomerase and vault MDR proteins at the mRNA expression level , using the reverse transcription PCR ( RT PCR ) . ^^^ After IFN alpha exposure , we observed either no effect , a trend towards a decrease of hTERT , MRP , and Topo IIalpha , or an increase of TEP 1 , MDR 1 , and LRP mRNA expression in some cell lines . ^^^ No correlation was found between hTERT and TEP 1 mRNA expression , whereas significant positive correlations were found between TEP 1 and MDR 1 mRNA , and between TEP 1 and LRP mRNA . ^^^ Positive correlation between TEP 1 and LRP also seems to identify them as common targets of IFN alpha effects . . ^^^ |
|
| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14764 and P60484 |
Pubmed |
SVM Score :0.0 |
| NA |
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