| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| The human homologs of the MCM 2 ( BM 28 ) , Mis 5 , Cdc 21 , and CDC 47 proteins were tightly bound to a histone Sepharose column and purified to near homogeneity , whereas the P1 / MCM3 and CDC46 / MCM5 proteins passed through . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| This gene family includes Saccharomyces cerevisiae MCM 2 , MCM 3 , MCM5 / CDC46 and CDC 47 , S . pombe nda 1 , nda 4 , cdc 21 and mis 5 , and genes encoding human BM 28 , P1MCM3 and P1 . 1MCM3 and mouse P1MCM3 , most of which are considered to be required for the initiation of DNA replication . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The members of the MCM protein family , including MCM 2 , MCM 3 , Cdc 21 , CDC 46 , Mis 5 and CDC 47 , are considered to be involved in the control of a single round of DNA replication during S phase in eukaryotes . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| Following exit from mitosis , the Mcm 4 subunit of the cytosolic interphase complex undergoes dephosphorylation , and the Mcm 2 , Mcm 3 , or Mcm 6 subunits are then actively phosphorylated by kinase ( s ) other than cyclin dependent kinases ( Cdks ) or Cdc 7 . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| HsMcm 10 also interacted with Orc 2 , Mcm 2 and Mcm 6 proteins in the yeast two hybrid system . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| Finally , using protein protein cross linking we have shown that MCM 2 interacts directly with MCM 5 and MCM 6 ; MCM 5 with MCM 3 and MCM 2 ; and MCM 6 with MCM 2 and MCM 4 . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| Cdc 23 shows genetic interactions with four MCM subunits : cdc 23 M36 and cdc 23 1E2 alleles both show synthetic phenotypes with mcm 2 ( cdc 19 P1 ) and mcm 6 ( mis 5 268 ) , and cdc 23 M36 is synthetically lethal with mcm 4 ( cdc 21 K46 ) and with mcm 5 ( nda 4 108 ) . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| In ATC , high MCM 5 and MCM 7 expression was paralleled by high levels of MCM 2 and MCM 6 . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| Our group purified MCM protein complexes consisting of MCM 2 , 4 ( Cdc 21 ) , 6 ( Mis 5 ) , and 7 ( CDC 47 ) proteins from HeLa cells by using histone Sepharose column chromatography ( Ishimi , Y . , Ichinose , S . , Omori , A . , Sato K . , and Kimura , H . ( 1996 ) J . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| We compared the effects of disruptions of cdc 19 ( + ) ( mcm 2 ( + ) ) , cdc 21 ( + ) ( mcm 4 ( + ) ) , nda 4 ( + ) ( mcm 5 ( + ) ) and mis 5 ( + ) ( mcm 6 ( + ) ) ; in all cases , the null mutants underwent delayed S phase but were unable to proceed through the cell cycle . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| In this study , we have expressed and isolated the mouse Mcm 2 , 4 , 6 , 7 proteins from insect cells and characterized various mutant Mcm 4 , 6 , 7 complexes in which the conserved ATPase motifs of the Mcm 4 and Mcm 6 proteins were mutated . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| Here , we report that Notch mediated cell cycle arrest is associated with downregulation of MCM 2 and MCM 6 in endothelial cells and human fibroblasts . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| Here , we show that expression levels of at least three of the PfMCM subunits , the homologues of MCM 2 , MCM 6 and MCM 7 , change during the intraerythrocytic development cycle , peaking in schizont and decreasing in the ring and trophozoite stages . ^^^ |
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| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| An emerging class of markers , the minichromosome maintenance protein family of DNA licensing factors ( MCM 2 , MCM 6 , MCM 7 ) , shows promise for the specific detection of high grade cervical disease using simple antibody based immunochemistry formats . ^^^ |
|
| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14566 and P49736 |
Pubmed |
SVM Score :0.0 |
| NA |
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