| Interacting proteins: Q14566 and P33992 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The members of the MCM protein family , including MCM 2 , MCM 3 , Cdc 21 , CDC 46 , Mis 5 and CDC 47 , are considered to be involved in the control of a single round of DNA replication during S phase in eukaryotes . ^^^ |
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| Interacting proteins: Q14566 and P33992 |
Pubmed |
SVM Score :0.0 |
| We compared the effects of disruptions of cdc 19 ( + ) ( mcm 2 ( + ) ) , cdc 21 ( + ) ( mcm 4 ( + ) ) , nda 4 ( + ) ( mcm 5 ( + ) ) and mis 5 ( + ) ( mcm 6 ( + ) ) ; in all cases , the null mutants underwent delayed S phase but were unable to proceed through the cell cycle . ^^^ |
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| Interacting proteins: Q14566 and P33992 |
Pubmed |
SVM Score :0.0 |
| Cell growth regulated expression of mammalian MCM 5 and MCM 6 genes mediated by the transcription factor E2F . ^^^ Human MCM 5 and MCM 6 promoters with mutation in the E2F sites failed in promoter regulation following serum stimulation and exogenous E2F expression . ^^^ Our results demonstrated that the growth regulated expression of mammalian MCM 5 and MCM 6 genes , and presumably other MCM members , is primarily regulated by E2F through binding to multiple E2F sites in the promoters . . ^^^ |
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| Interacting proteins: Q14566 and P33992 |
Pubmed |
SVM Score :0.0 |
| Finally , using protein protein cross linking we have shown that MCM 2 interacts directly with MCM 5 and MCM 6 ; MCM 5 with MCM 3 and MCM 2 ; and MCM 6 with MCM 2 and MCM 4 . ^^^ |
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| Interacting proteins: Q14566 and P33992 |
Pubmed |
SVM Score :0.0 |
| Cdc 23 shows genetic interactions with four MCM subunits : cdc 23 M36 and cdc 23 1E2 alleles both show synthetic phenotypes with mcm 2 ( cdc 19 P1 ) and mcm 6 ( mis 5 268 ) , and cdc 23 M36 is synthetically lethal with mcm 4 ( cdc 21 K46 ) and with mcm 5 ( nda 4 108 ) . ^^^ Two hybrid analysis demonstrates interactions at the protein protein level between Cdc 23 and Mcm 4 , Mcm 5 and Mcm 6 . ^^^ |
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| Interacting proteins: Q14566 and P33992 |
Pubmed |
SVM Score :0.0 |
| In ATC , high MCM 5 and MCM 7 expression was paralleled by high levels of MCM 2 and MCM 6 . ^^^ |
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