| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| However , physiological Notch stimulation through ligand binding results in the selective induction of HERP 2 but not HERP 1 mRNA and causes only marginal up regulation of HES 1 mRNA . ^^^ |
|
| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| Human Sir 2 related protein SIRT 1 associates with the bHLH repressors HES 1 and HEY 2 and is involved in HES 1 and HEY 2 mediated transcriptional repression . ^^^ |
|
| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| Notch 4 activation also induced the expression of the transcriptional repressors , HES 1 , HERP 1 , and HERP 2 , as well as ephrinB 2 , an angiogenic factor proposed to be involved in arterial / venous endothelial cell specification . . ^^^ |
|
| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| Moreover , the levels of both Notch 1 and Notch 4 intracellular domains were elevated , leading to stimulation of downstream transcriptional pathways involving Hes 1 , Herp 1 , and Herp 2 . ^^^ |
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| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| In the mouse , notch pathway genes such as Lfng , Hes 1 , Hes 7 , and Hey 2 display dynamic patterns of expression in paraxial mesoderm , cycling in synchrony with somite formation ( Aulehla and Johnson : Dev Biol 207 : 49 61 , 1999 ; Forsberg et al . : Curr Biol 8 : 1027 1030 , 1998 ; Jouve et al . : Development 127 : 1421 1429 , 2000 ; McGrew et al . : Curr Biol 8 : 979 982 , 1998 ; Nakagawa et al . : Dev Biol 216 : 72 84 , 1999 ) . ^^^ |
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| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| HES 1 , HES 5 , HEY 1 and HEY 2 are Notch target genes . ^^^ Phylogenetic analyses revealed that bHLH transcription factors with ORANGE domain were classified into the following three groups : ( group 1 ) HES 1 , HES 2 , HES 4 and HES 6 orthologs ; ( group 2 ) HESL , HES 5 , HES 7 , HEY 1 , HEY 2 and HEYL orthologs ; ( group 3 ) HES 3 , DEC1 / BHLHB2 and DEC2 / BHLHB3 orthologs . . ^^^ |
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| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| The HES family members Hey 1 ( hairy / enhancer of split related with YRPW motif 1 ) and Hey 2 co immunoprecipitate with Ptf 1 p48 , and Ptf 1 p48 binding by Hes 1 is also evident in yeast two hybrid and GST ( glutathione S transferase ) pull down assays . ^^^ |
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| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| Expression of HES / HEY family members , including HES 1 , HES 2 , HES 3 , HES 4 , HES 5 , HES 6 , HES 7 , HEY 1 , HEY 2 and HEYL , in coronary artery endothelial cells was not detected in silico . ^^^ |
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| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| Nuclear complex , consisting of CSL ( RBPSUH ) , NICD , Mastermind ( MAML ) , p 300 and histone acetyltransferase ( HAT ) , then induces transcriptional activation of Notch target genes , such as HES 1 , HES 5 , HES 7 , HEY 1 , HEY 2 and HEYL . ^^^ |
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| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| Here we show that Hrt 2 and Hes 1 interact with RBP Jkappa to negatively regulate Notch dependent activation of Hrt and Hes expression . ^^^ |
|
| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14469 and Q9UBP5 |
Pubmed |
SVM Score :0.0 |
| NA |
|