| These include up regulated transcription factors ( SOCS 3 , JAK 2 , STAT 3 , CREM , IRF 1 , SMN , silencer factor B , ANIA 3 , ANIA 4 , and HES 1 ) and signal transduction pathways ( cpg 21 , Narp , and CRBP ) and down regulated transmitter release mechanisms ( CITRON , synaptojanin 2 , ras related rab 3 , neurexin 1beta , and SNAP25A and B ) , kinases ( IP 3 kinase , Pak 1 , Ca ( 2+ ) / CaM dependent protein kinases ) , and ion channels ( K ( + ) channels TWIK , RK 5 , X 62839 , and Na ( + ) channel 1 ) . ^^^ |