| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| In this study , we analyzed the interaction of leukemia associated RhoGEF ( LARG ) , which also contains RGS domain , with Galpha 12 and Galpha 13 . ^^^ |
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| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Critical role of lysine 204 in switch 1 region of Galpha 13 for regulation of p115RhoGEF and leukemia associated RhoGEF . ^^^ Direct regulation of the activity of RGS RhoGEFs p 115 or leukemia associated RhoGEF ( LARG ) by Galpha 13 has previously been demonstrated . ^^^ |
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| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Unlike the RGS box of p 115 RhoGEF , the RGS box of LARG interacts not only with G alpha 12 and G alpha 13 but also with G alpha q . ^^^ In cellular coimmunoprecipitation studies , the LARG RGS box formed stable complexes with the transition state mimetic forms of G alpha q , G alpha 12 , and G alpha 13 . ^^^ Expression of the LARG RGS box diminished the transforming activity of oncogenic G protein coupled receptors ( Mas , G2A , and m 1 muscarinic cholinergic ) coupled to G alpha q and G alpha 13 . ^^^ Activated G alpha q , as well as G alpha 12 and G alpha 13 , cooperated with LARG and caused synergistic activation of RhoA , suggesting that all three G alpha subunits stimulate LARG mediated activation of RhoA . ^^^ |
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| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZN5 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|