| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Functional interaction of G alpha 13 with p115RhoGEF determined with transcriptional reporter system . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Mapping the Galpha 13 binding interface of the rgRGS domain of p115RhoGEF . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Critical role of lysine 204 in switch 1 region of Galpha 13 for regulation of p115RhoGEF and leukemia associated RhoGEF . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| G alpha 13 signals via p115RhoGEF cascades regulating JNK 1 and primitive endoderm formation . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Galpha 13 requires palmitoylation for plasma membrane localization , Rho dependent signaling , and promotion of p 115 RhoGEF membrane binding . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of p 115 RhoGEF or Galpha 13 , which activates p 115 RhoGEF activity , leads to inhibition of HIV 1 replication . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| We have shown that p115RhoGEF , a newly identified GEF ( guanine nucleotide exchange factor ) for RhoGTPase , has a RGS domain at its N terminal region and this domain acts as a specific GAP for Galpha 12 and Galpha 13 . ^^^ Furthermore , binding of activated Galpha 13 to this RGS domain stimulated GEF activity of p115RhoGEF . ^^^ Thus p115RhoGEF is a direct link between heterotrimeric G protein and RhoGTPase and it functions as an effector for Galpha 12 and Galpha 13 in addition to acting as their GAP . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Unlike the RGS box of p 115 RhoGEF , the RGS box of LARG interacts not only with G alpha 12 and G alpha 13 but also with G alpha q . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Recently , we identified p115RhoGEF , one of the guanine nucleotide exchange factors ( GEFs ) for Rho , as a direct link between Galpha 13 and Rho [ Kozasa , T . , et al . ( 1998 ) Science 280 , 2109 2111 ; Hart , M . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| For example , p 115 RhoGEF transduces Galpha 13 signals to Rho and inhibits Galpha12 / 13 signals via the RhoGEF LH domain which links to Galpha subunits . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| To investigate whether Galpha 12 and Galpha 13 are involved in thymopoiesis , we expressed the regulator of G protein signaling domain of p115RhoGEF to inhibit Galpha 12 and Galpha 13 during thymopoiesis . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| We present here the crystal structure of the rgRGS domain of p115RhoGEF in complex with a chimera of Galpha 13 and Galphai 1 . ^^^ |
|
| Interacting proteins: Q92888 and Q14344 |
Pubmed |
SVM Score :0.0 |
| Specific inhibition of Galpha 13 protein by the RGS domain of a guanine nucleotide exchange factor , p115RhoGEF , inhibited thrombin dependent phosphorylation of VASP . ^^^ |
|