| Interacting proteins: Q9NX02 and Q14191 |
Pubmed |
SVM Score :1.1504883 |
| Here , we show that WRN associates with the Mre 11 complex via binding to Nbs 1 in vitro and in vivo . 1.1504883^^^ |
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| Interacting proteins: Q9NX02 and Q14191 |
Pubmed |
SVM Score :0.0 |
| Mutations in ATM , NBS 1 , MRE 11 , BLM , WRN , and FANCD 2 are responsible for ataxia telangiectasia ( AT ) , Nijmegen breakage syndrome , AT like disorder , Bloom and Werner syndrome , and Fanconi anemia group D 2 , respectively . ^^^ |
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| Interacting proteins: Q9NX02 and Q14191 |
Pubmed |
SVM Score :0.0 |
| The WRN protein is mutated in the chromosomally unstable Werner syndrome ( WS ) and the Nbs 1 protein is mutated in Nijmegen breakage syndrome ( NBS ) . ^^^ While the DNA damage inducible Nbs 1 foci formation is normal in WS cells , WRN focus formation is defective in NBS cells . ^^^ Consistent with this , gamma H2AX colocalizes with Nbs 1 in WS cells but not with WRN in NBS cells . ^^^ The defective WRN gamma H2AX association in NBS cells can be complemented with wild type Nbs 1 , but not with an Nbs 1 S343A point mutant that lacks an ATM phosphorylation site . ^^^ Our results suggest a novel pathway in which Nbs 1 may recruit WRN to the site of DNA DSBs in an ATM dependent manner . . ^^^ |
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| Interacting proteins: Q9NX02 and Q14191 |
Pubmed |
SVM Score :0.0 |
| The accumulation of WRN at double strand breaks was rapid , persisted for many hours , and occurred in the absence of several known interacting proteins including polymerase beta , poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , Ku 80 , DNA dependent protein kinase ( DNA PKcs ) , NBS 1 and histone H2AX . ^^^ |
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| Interacting proteins: Q9NX02 and Q14191 |
Pubmed |
SVM Score :0.0 |
| We analyzed one or more single nucleotide polymorphisms ( SNPs ) in each of seven candidate genes ( WRN , TP 53 , NBS 1 , BRCA 1 , BRCA 2 , XRCC 3 and XRCC 4 ) in a study of 250 workers exposed to benzene and 140 controls in China . ^^^ |
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| Interacting proteins: Q9NX02 and Q14191 |
Pubmed |
SVM Score :0.0 |
| To identify additional proteins required for the recruitment of BLM , we examined the recruitment of BLM in various mutants generated from chicken DT 40 cells and found that the early accumulation of BLM was not dependent on the presence of ATM , RAD 17 , DNA PKcs , NBS 1 , XRCC 3 , RAD 52 , RAD 54 , or WRN . ^^^ |
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