| Interacting proteins: Q15554 and Q14191 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15554 and Q14191 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15554 and Q14191 |
Pubmed |
SVM Score :0.0 |
| The telomere binding proteins TRF 1 and TRF 2 limit digestion by WRN . ^^^ |
|
| Interacting proteins: Q15554 and Q14191 |
Pubmed |
SVM Score :0.0 |
| Furthermore , WRN RNAi induced DNA damage was suppressed by overexpression of the telomere binding protein TRF 2 . ^^^ |
|
| Interacting proteins: Q15554 and Q14191 |
Pubmed |
SVM Score :0.0 |
| In human cells , we report that WRN co localizes and physically interacts with the critical telomere maintenance protein TRF 2 . ^^^ In vitro , TRF 2 demonstrates high affinity for WRN and for another RecQ family member , the Bloom syndrome protein ( BLM ) . ^^^ TRF 2 interaction with either WRN or BLM results in a notable stimulation of their helicase activities . ^^^ Furthermore , the WRN and BLM helicases , partnered with replication protein A , actively unwind long telomeric duplex regions that are pre bound by TRF 2 . ^^^ These results suggest that TRF 2 functions with WRN , and possibly BLM , in a common pathway at telomeric ends . . ^^^ |
|
| Interacting proteins: Q15554 and Q14191 |
Pubmed |
SVM Score :0.0 |
| WRN has been demonstrated to bind to a variety of other proteins , including RPA , DNA PKcs , and TRF 2 , suggesting that WRN is involved in DNA replication , repair , recombination , and telomere maintenance . ^^^ |
|
| Interacting proteins: Q15554 and Q14191 |
Pubmed |
SVM Score :0.0 |
| TRF 2 recruits the Werner syndrome ( WRN ) exonuclease for processing of telomeric DNA . ^^^ This notion is strongly supported by our finding of physical and functional interactions between WRN and TRF 2 , a telomeric repeat binding factor essential for proper telomeric structure . ^^^ TRF 2 binds to DNA substrates containing telomeric repeats and facilitates their degradation specifically by WRN exonuclease activity . ^^^ WRN and TRF 2 also interact directly in the absence of DNA . ^^^ These results suggest that TRF 2 recruits WRN for accurate processing of telomeric structures in vivo . ^^^ |
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| Interacting proteins: Q15554 and Q14191 |
Pubmed |
SVM Score :0.0 |
| The TRF 2 DSB response requires the TRF 2 basic domain but not its Myb domain and occurs in the absence of functional ATM and DNA PK protein kinases , MRE11 / Rad50 / NBS1 complex and Ku 70 , WRN and BLM repair proteins . ^^^ |
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