| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| Putative ATM in vitro targets include p95 / nibrin , Mre 11 , Brca 1 , Rad 17 , PTS , WRN , and ATM ( S 440 ) itself . ^^^ |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| Mutations in ATM , NBS 1 , MRE 11 , BLM , WRN , and FANCD 2 are responsible for ataxia telangiectasia ( AT ) , Nijmegen breakage syndrome , AT like disorder , Bloom and Werner syndrome , and Fanconi anemia group D 2 , respectively . ^^^ |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| Proteins with these dual roles occur in : ( 1 ) HRR ( BRCA 1 , ATM , ATR , WRN , BLM , Tip 60 and p 53 ) ; ( 2 ) NHEJ ( the catalytic subunit of DNA PK ) ; ( 3 ) NER ( XPB , XPD , p 53 and p 33 ( ING1b ) ) ; ( 4 ) BER ( Ref 1 / Ape , poly ( ADP ribose ) polymerase 1 ( PARP 1 ) and p 53 ) ; ( 5 ) MMR ( MSH 2 , MSH 6 , MLH 1 and PMS 2 ) . ^^^ Such proteins include BRCA 1 , ATM , WRN , BLM , p 53 , XPB , XPD , MSH 2 , MSH 6 , MLH 1 and PMS2 . . ^^^ |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| Ionizing radiation also induces WRN translocation , albeit milder , partially through activation of the ATM kinase . ^^^ |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| The frequency of DNA deletions by homologous recombination at the pink eyed unstable ( p ( un ) ) locus is elevated in mice with mutations in ATM , Trp 53 , Gadd 45 , and WRN genes and after exposure to carcinogens . ^^^ |
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| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| This band was also completely supershifted by the addition of antibodies to ATM , Ku 70 , DNA ligase 3 , Rpa 32 , Rpa 14 , DNA ligase 4 , XRCC 4 , WRN , BLM , RAD 51 and p 53 . ^^^ The density of one of the DNA EBCs predicted the radiosensitization caused by BRCA haploinsufficiency , and this band contains Ku 70 , ATM , DNA ligase 3 , Rpa 32 , Rpa 14 , DNA ligase 4 , XRCC 4 , WRN , BLM , RAD 51 and p 53 but not BRCA 1 or 2 . ^^^ |
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| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| We found no statistical evidence that GHRHR , IGF1R , INSR , PROP 1 , or TRX delay or that ATM + TERC , BubR 1 , klotho , LMNA , PRDX 1 , p 53 , WRN + TERC , or TOP3B accelerate mouse aging . ^^^ |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| The TRF 2 DSB response requires the TRF 2 basic domain but not its Myb domain and occurs in the absence of functional ATM and DNA PK protein kinases , MRE11 / Rad50 / NBS1 complex and Ku 70 , WRN and BLM repair proteins . ^^^ |
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| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| The defective WRN gamma H2AX association in NBS cells can be complemented with wild type Nbs 1 , but not with an Nbs 1 S343A point mutant that lacks an ATM phosphorylation site . ^^^ Our results suggest a novel pathway in which Nbs 1 may recruit WRN to the site of DNA DSBs in an ATM dependent manner . . ^^^ |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| To identify additional proteins required for the recruitment of BLM , we examined the recruitment of BLM in various mutants generated from chicken DT 40 cells and found that the early accumulation of BLM was not dependent on the presence of ATM , RAD 17 , DNA PKcs , NBS 1 , XRCC 3 , RAD 52 , RAD 54 , or WRN . ^^^ |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and Q13315 |
Pubmed |
SVM Score :0.0 |
| NA |
|