| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.58540436 |
| First , we showed that WRN forms a complex with DNA PKcs and Ku in solution . 0.58540436^^^ |
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| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.0 |
| Because Ku and DNA PKcs , the catalytic subunit of DNA dependent protein kinase ( DNA PK ) , form a complex at DNA ends , we have now explored the possibility of functional modulation of WRN exonuclease activity by DNA PK . ^^^ We find that although DNA PKcs alone does not affect the WRN exonuclease activity , the additional presence of Ku mediates a marked inhibition of it . ^^^ The inhibition of WRN exonuclease by DNA PKcs requires the kinase activity of DNA PKcs . ^^^ WRN is a target for DNA PKcs phosphorylation , and this phosphorylation requires the presence of Ku . ^^^ WRN is phosphorylated in vivo after treatment of cells with DNA damaging agents in a pathway that requires DNA PKcs . ^^^ |
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| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.0 |
| WRN has been demonstrated to bind to a variety of other proteins , including RPA , DNA PKcs , and TRF 2 , suggesting that WRN is involved in DNA replication , repair , recombination , and telomere maintenance . ^^^ |
|
| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.0 |
| Proteins directly involved in telomere maintenance and DNA damage response include Ku , DNA PKcs , RAD51D , PARP 2 , WRN and RAD50 / MRE11 / NBS1 complex . ^^^ |
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| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.0 |
| The accumulation of WRN at double strand breaks was rapid , persisted for many hours , and occurred in the absence of several known interacting proteins including polymerase beta , poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , Ku 80 , DNA dependent protein kinase ( DNA PKcs ) , NBS 1 and histone H2AX . ^^^ |
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| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.0 |
| To identify additional proteins required for the recruitment of BLM , we examined the recruitment of BLM in various mutants generated from chicken DT 40 cells and found that the early accumulation of BLM was not dependent on the presence of ATM , RAD 17 , DNA PKcs , NBS 1 , XRCC 3 , RAD 52 , RAD 54 , or WRN . ^^^ |
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| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P78527 |
Pubmed |
SVM Score :0.0 |
| NA |
|