| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.58497691 |
| The interaction of WRN protein with RPA ( replication protein A ) and p 53 will undoubtedly direct efforts to further dissect the genetic pathway ( s ) in which WRN protein functions in DNA metabolism and will help to unravel its contribution to the human aging process . . 0.58497691^^^ |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :1.1836705 |
| WRN has been shown to bind to and / or functionally interact with other proteins , including replication protein A ( RPA ) , proliferating cell nuclear antigen ( PCNA ) , DNA topoisomerase 1 , Ku 86 / 70 , DNA polymerase delta and p 53 . 1.1836705^^^ |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.53836369 |
| Results from coimmunoprecipitation studies indicate that WRN is associated with replication protein A ( RPA ) and p 53 in vivo before and after treatment with the replication inhibitor hydroxyurea or gamma irradiation that introduces DNA strand breaks . 0.53836369^^^ |
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| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.59722731 |
| WRN ( H R ) helicase activity was significantly reduced on RPA dependent partial duplex substrates compared with full length WRN despite the presence of RPA . 0.59722731^^^ |
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| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| WRN interacts physically and functionally with replication protein A ( RPA ) , which stimulates its helicase activity . ^^^ |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| Werner ' s syndrome protein ( WRN ) migrates Holliday junctions and co localizes with RPA upon replication arrest . ^^^ In cells arrested in S phase with hydroxyurea , WRN localizes to discrete nuclear foci that coincide with those formed by the single stranded DNA binding protein replication protein A . ^^^ |
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| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| We analyzed the simultaneous action of WRN activities on the long forked duplex in the presence of the WRN protein partners , replication protein A ( RPA ) , and the Ku70 / 80 heterodimer . ^^^ RPA stimulated the WRN helicase , whereas Ku stimulated the WRN exonuclease . ^^^ In the presence of both RPA and Ku , the WRN helicase activity dominated the exonuclease activity . . ^^^ |
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| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| WRN has been demonstrated to bind to a variety of other proteins , including RPA , DNA PKcs , and TRF 2 , suggesting that WRN is involved in DNA replication , repair , recombination , and telomere maintenance . ^^^ |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| Our previous studies indicated that the activity of Werner syndrome helicase ( WRN ) could be stimulated by human replication protein A ( hRPA ) , a heterotrimeric single stranded DNA binding protein . ^^^ |
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| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| The single stranded DNA binding protein RPA , an auxiliary factor for WRN helicase , enabled the DNA unwinding enzyme to overcome inhibition by either the trans R or cis R BaP DE dG adduct , suggesting that WRN and RPA may function together to unwind duplex DNA harboring specific covalent adducts that otherwise block WRN helicase acting alone . . ^^^ |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P27694 |
Pubmed |
SVM Score :0.0 |
| NA |
|