| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.64131243 |
| Protein protein interaction studies reveal that WRN binds directly to Ku 80 and that this interaction is mediated by the amino terminus of WRN . 0.64131243^^^ |
|
| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.0 |
| In addition , our data indicate that the region of Ku 80 between amino acids 215 and 276 is necessary for binding to WRN . ^^^ |
|
| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.0 |
| The Ku 70 subunit specifically interacts with the N terminus ( amino acids 1 368 ) of WRN , while the Ku 80 subunit interacts with its C terminus ( amino acids 940 1432 ) . ^^^ A mutant Ku heterodimer of full length Ku 80 and truncated Ku 70 ( amino acids 430 542 ) interacts with C WRN but not with N WRN and can not stimulate WRN exonuclease activity . ^^^ The interaction between Ku 80 and the C terminus of WRN may modulate some other , as yet unknown , function . ^^^ |
|
| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.0 |
| These are the causative genes for Xeroderma pigmentosum ( XPB and XPD ) , Cockayne syndrome ( CSB ) , diffuse collagen disease ( Ku 80 ) , alpha thalassmia ( ATR 10 ) , Bloom syndrome ( BLM ) , Werner syndrome ( WRN ) and Rothmund Thomson syndrome ( RTS ) . ^^^ |
|
| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.0 |
| Finally , YB 1 affinity chromatography experiments have indicated that in addition to prespliceosome factors like nucleolin and ALY , YB 1 binds the DNA repair proteins MSH 2 , DNA polymerase delta , Ku 80 and WRN proteins in vitro . ^^^ |
|
| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.0 |
| However , recruitment of the DNA repair proteins , WRN , Mre 11 , and Ku 86 , is not inhibited by a G quadruplex . ^^^ |
|
| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.0 |
| The accumulation of WRN at double strand breaks was rapid , persisted for many hours , and occurred in the absence of several known interacting proteins including polymerase beta , poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , Ku 80 , DNA dependent protein kinase ( DNA PKcs ) , NBS 1 and histone H2AX . ^^^ |
|
| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P13010 |
Pubmed |
SVM Score :0.0 |
| NA |
|