| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :1.4012534 |
| WRN has been shown to bind to and / or functionally interact with other proteins , including replication protein A ( RPA ) , proliferating cell nuclear antigen ( PCNA ) , DNA topoisomerase 1 , Ku 86 / 70 , DNA polymerase delta and p 53 . 1.4012534^^^ |
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| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.99474073 |
| We demonstrate co localisation of WRN and PCNA at replication factories , show that PCNA binds to two distinct functional sites on WRN , and suggest a mechanism by which association between WRN and PCNA may be regulated in cells on DNA damage and during DNA replication . . 0.99474073^^^ We show that wild type WRN protein physically associates with PCNA at physiological protein concentrations in normal cells , while no association is seen in cells from patients with WS . 0.54600667^^^ |
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| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| WRN increases the rate of nucleotide incorporation by pol delta in the absence of proliferating cell nuclear antigen ( PCNA ) but does not stimulate the activity of eukaryotic DNA polymerases alpha or epsilon , or a variety of other DNA polymerases . ^^^ |
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| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| These results indicate that the mechanism whereby WRN stimulates FEN 1 cleavage is distinct from that proposed for the functional interaction between proliferating cell nuclear antigen and FEN 1 . ^^^ |
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| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| Here , we show that , following DNA replication arrest , WRN associates and colocalizes with the MRE 11 complex at PCNA sites . ^^^ |
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| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| The interaction site of Flap Endonuclease 1 with WRN helicase suggests a coordination of WRN and PCNA . ^^^ Both WRN and BLM bind to the extreme C terminal 18 amino acid tail of FEN 1 that is adjacent to the PCNA binding site of FEN 1 . ^^^ The importance of the WRN / BLM physical interaction with the FEN 1 C terminal tail was confirmed by functional interaction studies with catalytically active purified recombinant FEN 1 deletion mutant proteins that lack either the WRN / BLM binding site or the PCNA interaction site . ^^^ The distinct binding sites of WRN and PCNA and their combined effect on FEN 1 nuclease activity suggest that they may coordinately act with FEN 1 . ^^^ These studies provide new insights to the interaction of WRN and BLM helicases with FEN 1 , and how these interactions might be regulated with the PCNA FEN 1 interaction during DNA replication and repair . . ^^^ |
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| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14191 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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