| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.62470603 |
| Saccharomyces cerevisiae protein Pci8p and human protein eIF3e / Int 6 interact with the eIF 3 core complex by binding to cognate eIF3b subunits . 0.62470603^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.67392277 |
| Fission yeast Int 6 was shown to interact with other presumptive components of eIF 3 in vivo , and was present in size fractions consistent with its incorporation into a 43S translation preinitiation complex . 0.67392277^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| The Int 6 gene is a site of mouse mammary tumour virus ( MMTV ) integration in murine tumours and INT 6 protein has been identified independently as a subunit ( eIF3e ) of the eukaryotic translation initiation factor eIF 3 . ^^^ Here , using immunofluorescence microscopy , we show that eIF3e / INT6 is localized in part to the nucleus , while other eIF 3 components are cytoplasmic . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Here we describe the association between components of the COP 9 signalosome ( CSN 1 , CSN 7 , and CSN 8 ) and two subunits of eukaryotic translation initiation factor 3 ( eIF 3 ) , eIF3e ( p 48 , known also as INT 6 ) and eIF3c ( p 105 ) . ^^^ To obtain a biochemical marker for Arabidopsis eIF 3 , we cloned the Arabidopsis ortholog of the eIF 3 subunit eIF3b ( PRT 1 ) . eIF3e coimmunoprecipitated with CSN 7 , and eIF3c coimmunoprecipitated with eIF3e , eIF3b , CSN 8 , and CSN 1 . eIF3e directly interacted with CSN 7 and eIF3c . ^^^ Whereas eIF 3 , as detected through eIF3b , localized solely to the cytoplasm , eIF3e , like CSN 7 , was also found in the nucleus . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| The murine int 6 locus , identified as a frequent integration site of mouse mammary tumor viruses , encodes the 48 kDa eIF3e subunit of translation initiation factor eIF 3 . ^^^ Previous studies indicated that the catalytically active core of budding yeast eIF 3 consists of five subunits , all conserved in eukaryotes , but does not contain a protein closely related to eIF3e / Int 6 . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Moe 1 and spInt 6 , the fission yeast homologues of mammalian translation initiation factor 3 subunits p 66 ( eIF3d ) and p 48 ( eIF3e ) , respectively , are required for stable association of eIF 3 subunits . ^^^ These phenotypes of Deltamoe 1 cells are similar to those reported previously for deletion of the fission yeast int 6 ( + ) gene that encodes the fission yeast homologue of the p48 / Int6 / eIF3e subunit of mammalian eIF 3 . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| The 2 novel genes ( RS 91 and RS 2 ) from the renal tissue were both very similar to serine ( or cysteine ) proteinase inhibitor , clade F and eukaryotic translation initiation factor 3 and subunit 5 ( EIF 3 epsilon ) . ^^^ We believe the 2 novel genes to be the serine proteinase inhibitors clade F and EIF 3 epsilon in rats . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| It has been shown previously that p 56 is able to bind the eukaryotic initiation factor 3e ( eIF3e ) ( p48 / Int 6 ) subunit of the eukaryotic translation initiation factor eIF 3 and function as an inhibitor of translation in vitro and in vivo . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes . : BACKGROUND : PCI / MPN domain protein complexes comprise the 19S proteasome lid , the COP 9 signalosome ( CSN ) , and eukaryotic translation initiation factor 3 ( eIF 3 ) . ^^^ RESULTS : Here , we report the unexpected finding that fission yeast has two distinct eIF 3 complexes sharing common core subunits , but distinguished by the PCI proteins eIF3e and the novel eIF3m , which was previously annotated as a putative CSN subunit . ^^^ CONCLUSION : We propose that the PCI proteins eIF3e and eIF3m define distinct eIF 3 complexes that may assist in the translation of different sets of mRNAs . . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Translation initiation factor eIF4G 1 binds to eIF 3 through the eIF3e subunit . eIF 3 in mammals is the largest translation initiation factor ( approximately 800 kDa ) and is composed of 13 nonidentical subunits designated eIF3a m . ^^^ However , binding of partially proteolyzed HeLa eIF 3 to the eIF 3 binding domain of human eIF4G 1 , followed by high throughput analysis of mass spectrometric data with a novel peptide matching algorithm , identified a single subunit , eIF3e ( p48 / Int 6 ) . ^^^ In addition , recombinant FLAG eIF3e specifically competed with HeLa eIF 3 for binding to eIF4G in vitro . ^^^ These data suggest a specific , direct , and functional interaction of eIF3e with eIF4G during the process of cap dependent translation initiation , although they do not rule out participation of other eIF 3 subunits . . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| The translation initiation factor eIF 3 p48 subunit is encoded by int 6 , a site of frequent integration by the mouse mammary tumor virus genome . ^^^ A search of the data base indicates that the mouse gene encoding eIF 3 p48 had previously been identified and characterized by others as int 6 . ^^^ We discuss how the cytosolic function of eIF 3 p48 ( Int 6 ) in protein synthesis may account for oncogenesis caused by these two viruses . . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| The INT 6 gene has been highly conserved through evolution and has recently been shown to encode the p 48 component of the eucaryotic translation initiation factor 3 ( eIF 3 ) complex . ^^^ The 1 . 5kb eIF 3p48 / INT 6 RNA species encodes a protein composed of 364 amino acid residues whose sequence is 71 % similar to that of the mouse / human eIF 3 / INT 6 amino acid sequence . eIF 3p48 / INT 6 RNA is expressed throughout development in Drosophila and the encoded protein is associated with the microsomal subcellular fraction . . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Screening of a human B cell cDNA library for proteins that interact with Int 6 led to isolation of four clones coding for the p 110 subunit of eIF 3 , in accordance with previous detection of Int 6 in purified forms of this translation initiation factor . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Mammalian INT 6 protein has been considered to be a subunit of the eukaryotic translation initiation factor , eIF 3 . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| The Int 6 protein has been shown to be a subunit of eukaryotic translation initiation factor 3 ( eIF 3 ) and to play a role in the control of cell growth . ^^^ It was observed that HSPC 021 coelutes with Int 6 and eIF 3 in gel filtration , coimmunoprecipitates with eIF 3 , and is incorporated into eIF 3 both in rabbit reticulocyte lysates and in COS 7 cells . ^^^ A direct protein protein interaction occurs between HSPC 021 and Int 6 , but the analysis of different mutants of HSPC 021 indicated that a larger region of the protein is necessary for incorporation into eIF 3 as compared with binding to Int 6 . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Association of the mammalian proto oncoprotein Int 6 with the three protein complexes eIF 3 , COP 9 signalosome and 26S proteasome . ^^^ The mammalian Int 6 protein has been characterized as a subunit of the eIF 3 translation initiation factor and also as a transforming protein when its C terminal part is deleted . ^^^ By performing a two hybrid screen with Int 6 as bait , we have isolated subunits belonging to all three complexes , namely eIF 3 p110 , Rpt 4 , CSN 3 and CSN 6 . ^^^ |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P60228 and Q14152 |
Pubmed |
SVM Score :0.0 |
| NA |
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