| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Several initiation factors ( eIF 2 , eIF 3 , eIF 4A , eIF 4B , eIF 4C , eIF 4E and eIF 5 ) and elongation factor 1 were found to have no such discriminatory effect . ^^^ |
|
| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| The extent of binding and the stability of the complex are enhanced by initiation factors eIF 3 and eIF 4C , AUG and elevated magnesium concentration . ^^^ |
|
| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Detailed information about the binding sites for eIF 1A , eIF 2 , eIF 3 , and Met tRNA ( 1 ) on the 40S ribosomal subunit was derived from the AFM images . ^^^ |
|
| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Distinct functions of eukaryotic translation initiation factors eIF1A and eIF 3 in the formation of the 40 S ribosomal preinitiation complex . ^^^ When the eIF1A dependent preinitiation reaction was carried out with 40 S ribosomal subunits that had been preincubated with eIF 3 , the 40 S preinitiation complex formed included bound eIF 3 ( 40 S . eIF3 . ^^^ These results suggest that in vivo , both eIF1A and eIF 3 are required to form a stable 40 S preinitiation complex , eIF1A catalyzing the transfer of Met tRNAf . eIF2 . ^^^ |
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| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| The cap binding complex eIF4F and the factors eIF4A and eIF4B are required for binding of 43S complexes ( comprising a 40S subunit , eIF2 / GTP / Met tRNAi and eIF 3 ) to the 5 ' end of capped mRNA but are not sufficient to promote ribosomal scanning to the initiation codon . eIF1A enhances the ability of eIF 1 to dissociate aberrantly assembled complexes from mRNA , and these factors synergistically mediate 48S complex assembly at the initiation codon . ^^^ |
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| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Mammalian translation initiation factor eIF 1 functions with eIF1A and eIF 3 in the formation of a stable 40 S preinitiation complex . ^^^ We observed that , although both eIF1A and eIF 3 are essential to generate a stable 40 S preinitiation complex , quantitative binding of the ternary complex to 40 S subunits also required eIF 1 . ^^^ The 40 S preinitiation complex contained , in addition to eIF 3 , both eIF 1 and eIF1A in a 1 : 1 stoichiometry with respect to the bound Met tRNA ( 1 ) . ^^^ In contrast , the binding of eIF1A to free 40 S ribosomes as well as to the 40 S preinitiation complex was stabilized by the presence of both eIF 1 and eIF 3 . ^^^ |
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| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Domains of eIF1A that mediate binding to eIF 2 , eIF 3 and eIF5B and promote ternary complex recruitment in vivo . ^^^ The unstructured N terminus of eIF1A interacts with eIF 2 and eIF 3 and is required at low temperatures for a step following TC recruitment . ^^^ |
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| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| These studies demonstrate that both eIF 1 and eIF1A are capable of binding to the 40S subunit in the absence of any other initiation factors or mRNA , arguing against previous suggestions that eIF 3 is required for recruitment of eIF 1 to the small ribosomal subunit . ^^^ |
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| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Here , we report that eIF 1 , eIF1A and eIF 3 do not significantly influence IRES / 40S subunit binding but strongly inhibit subunit joining and the first elongation cycle . ^^^ |
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| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| In this work , we show that the presence of initiation factors eIF 1 , eIF1A and eIF 3 in the 40S preinitiation complex ( 40S . eIF1 . eIF1A . eIF3 . ^^^ |
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| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| Recruitment of the eukaryotic translation initiation factor 2 ( eIF 2 ) GTP Met tRNAiMet ternary complex to the 40S ribosome is stimulated by multiple initiation factors in vitro , including eIF 3 , eIF 1 , eIF 5 , and eIF1A . ^^^ |
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| Interacting proteins: P47813 and Q14152 |
Pubmed |
SVM Score :0.0 |
| The reaction requires factors eIF 3 , eIF4C , and eIF 5 ; Met tRNA and the Met tRNA binding system ; either GTP or GMP PNP ; ATP ; and factors C 1 and eIF4A . ^^^ |
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