| The kelch repeats in the C terminus of human Keap 1 associate with the SH 3 domain of myosin VIIa . ^^^ Immunolocalization studies revealed that Keap 1 is present with myosin VIIa in the actin bundles of the ES . ^^^ Myosin VIIa and Keap 1 copurify with ES and colocate with each other and with F actin at the electron microscopy level . ^^^ Keap 1 can target to the ES in the absence of myosin VIIa , suggesting that Keap 1 associates with other molecules in the adhesion plaque . ^^^ Keap 1 and myosin VIIa overlapped in expression in the inner hair cells of the cochlea , suggesting that Keap 1 may be a part of a family of actin binding proteins that could be important for myosin VIIa function in testis and inner ear . . ^^^ |