| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Human apolipoprotein E receptor 2 . ^^^ Isolation and characterization of a human cDNA demonstrated a novel lipoprotein receptor designated apolipoprotein E receptor 2 ( apoER 2 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| The structures of the VLDL receptor , and recently identified apolipoprotein E receptor 2 , closely resemble the LDL receptor . ^^^ Apolipoprotein E receptor 2 is structurally most closely related to the LDL receptor and expressed predominantly in brain . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Exon / intron organization , chromosome localization , alternative splicing , and transcription units of the human apolipoprotein E receptor 2 gene . ^^^ Apolipoprotein E receptor 2 is a recently identified receptor that resembles low and very low density lipoprotein receptors . ^^^ Isolation and characterization of genomic clones encoding human apolipoprotein E receptor 2 revealed that the gene spans approximately 60 kilobases and contains 19 exons . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Avian and murine LR8B and human apolipoprotein E receptor 2 : differentially spliced products from corresponding genes . ^^^ The human receptor , termed `` apolipoprotein E receptor 2 , ' ' is a seven ligand binding repeat receptor harboring a unique insertion in the cytoplasmic domain of the protein . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Evolution of the apolipoprotein E receptor 2 gene by exon loss . ^^^ The apolipoprotein E receptor 2 ( apoER 2 ) gene consists of a mosaic of exons , which may have been assembled by `` exon shuffling . ' ' Analysis of apoER 2 transcripts in several species reveals a lost repeat in the ligand binding domain of primate apoER 2 . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Expression and alternate splicing of apolipoprotein E receptor 2 in brain . ^^^ We examined the brain expression of the most recently identified member of this receptor family , apolipoprotein E receptor 2 , in human brain and placenta . ^^^ We analysed apolipoprotein E receptor 2 messenger RNA by reverse transcription polymerase chain reaction and apolipoprotein E receptor 2 protein by immunohistochemistry . ^^^ Four exons of the apolipoprotein E receptor 2 message were alternately spliced in both fetal and adult brain tissue . ^^^ Exon 5 , encoding three of the seven ligand binding repeats , was absent in the apolipoprotein E receptor 2 messenger RNA examined . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Expression in vitro of alternatively spliced variants of the messenger RNA for human apolipoprotein E receptor 2 identified in human tissues by ribonuclease protection assays . ^^^ The apolipoprotein E receptor 2 ( apoER 2 ) , also called LR7 / 8B , is a member of the low density lipoprotein ( LDL ) receptor family that is expressed in brain . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Here , we report the requirement for two other proteins , cell surface receptors termed very low density lipoprotein receptor ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| The LDL R is the prototype of this family , which also contains very low density lipoprotein receptors ( VLDL R ) , apolipoprotein E receptor 2 , LRP , and megalin . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that Reelin binds directly to lipoprotein receptors , preferably the very low density lipoprotein receptor ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Very low density lipoprotein binding to the apolipoprotein E receptor 2 is enhanced by lipoprotein lipase , and does not require apolipoprotein E . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Cellular components of this signaling pathway characterized to date are cell surface receptors for reelin like apolipoprotein E receptor 2 ( ApoER 2 ) , very low density lipoprotein receptor ( VLDLR ) , and cadherin related neuronal receptors , and intracellular components like Disabled 1 and the nonreceptor tyrosine kinase Fyn , which bind to the intracellular domains of the ApoER 2 and VLDL receptor or of cadherin related neuronal receptors , respectively . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Some of them are preferentially expressed in the brain such as the LDL receptor related protein , the apolipoprotein E receptor 2 , and the very low density lipoprotein ( VLDL ) receptor . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| RELN encodes a large ( 388 kD ) secreted protein that acts on migrating cortical neurons by binding to the very low density lipoprotein receptor ( VLDLR ) , the apolipoprotein E receptor 2 ( ApoER 2 ; refs 9 11 ) , alpha3beta1 integrin and protocadherins . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| From cholesterol transport to signal transduction : low density lipoprotein receptor , very low density lipoprotein receptor , and apolipoprotein E receptor 2 . ^^^ In the third part of this review article , we provide first insight into the roles of the VLDL receptor and of another small relative , the so called apolipoprotein E receptor 2 , in such signaling processes . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue . ^^^ Four novel mRNA transcripts could be identified as isoforms of the apolipoprotein E receptor 2 ( apoEr 2 ) : one form lacking three ligand binding repeats ( nucleotides 497 883 ) but containing a novel ligand binding repeat adjacent to a unique cysteine rich domain preceding the epidermal growth factor precursor domain of apoEr 2 , forms lacking the O linked sugar domain , and forms containing a 59 amino acid deletion within the cytoplasmic tail . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Reelin is a secreted extracellular protein that binds to the very low density lipoprotein receptor and the apolipoprotein E receptor 2 on the surface of neurons . ^^^ Disabled 1 ( Dab 1 ) , an intracellular adapter protein containing a PTB ( phosphotyrosine binding ) domain , is tyrosyl phosphorylated during embryogenesis , but it accumulates in a hypophosphorylated form in mice lacking Reelin or both very low density lipoprotein receptor and apolipoprotein E receptor 2 . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Moreover , studies in VLDLR knockout mice that were also deficient in a second LDL receptor family member , the apolipoprotein E receptor 2 , indicated a role for the VLDLR in neuronal migration during brain development . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane . ^^^ It was widely assumed that other closely related members of the LDL R gene family would have similar functions , but recent experimental evidence has revealed that one such protein , apolipoprotein E receptor 2 ( apoER 2 ) , has a critical role as an `` outside in ' ' signal transducer in the brain . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata : morphologic evidence from reeler , apolipoprotein E receptor 2 , and very low density lipoprotein receptor knockout mice . ^^^ To study the role of granule cells for the lamina specific ingrowth of afferents , the cyto and fiberarchitecture of three mouse mutants ( very low density lipoprotein receptor knockout mouse , apolipoprotein E receptor 2 knockout mouse , and reeler mouse ) that show different degrees of granule cell migration defects were analyzed . ^^^ This laminar organization is mildly altered in very low density lipoprotein receptor knockout mice , moderately disturbed in apolipoprotein E receptor 2 knockout mice , and severely disrupted in reeler mice . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in Reelin , Disabled 1 ( Dab 1 ) , or both the very low density lipoprotein receptor ( VLDLR ) and the apolipoprotein E receptor 2 ( ApoER 2 ) exhibit identical neuroanatomic defects in laminar structures throughout the brain . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| We have studied the organization and cellular differentiation of dentate granule cells and their axons , the mossy fibers , in reeler mutant mice lacking reelin and in mutants lacking the reelin receptors very low density lipoprotein receptor ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2 , thereby inducing tyrosine phosphorylation of the adaptor protein Disabled 1 ( Dab 1 ) and suppressing tau phosphorylation in vivo . ^^^ We present genetic evidence that this cascade is dependent on apolipoprotein E receptor 2 , very low density lipoprotein receptor , and Dab 1 . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Low density lipoprotein receptor related protein 8 ( apolipoprotein E receptor 2 ) gene polymorphisms in Alzheimer ' s disease . ^^^ Previous studies had shown association of LDL receptor related protein ( LRP ) and AD , therefore we speculated that another member of this LDL receptor family , LRP 8 ( also called apolipoprotein E receptor 2 or ApoER 2 ) , which is predominantly expressed in brain , might be associated with Alzheimer ' s disease . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Transmission of the Reelin signal to migrating embryonic neurons requires binding to the very low density lipoprotein receptor ( VLDLR ) and the apolipoprotein E receptor 2 ( apoER 2 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Reelin , Disabled 1 ( Dab 1 ) , apolipoprotein E receptor 2 ( ApoER 2 ) , and very low density lipoprotein receptor ( VLDLR ) participate in a signaling pathway required for layer formation during mammalian brain development . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Essential role of the apolipoprotein E receptor 2 in sperm development . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Several candidate genes are localized under the peak linkages , including apolipoprotein H on chromosome 17q , the apolipoprotein E receptor 2 , and members of the phospholipase A 2 family on chromosome 1p as well as HMG CoA reductase on chromosome 5q . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Formation of the mammalian six layered neocortex depends on a signaling pathway that involves Reelin , the very low density lipoprotein receptor , the apolipoprotein E receptor 2 ( ApoER 2 ) , and the adaptor protein Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Dimers of beta 2 glycoprotein 1 increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2 ' . ^^^ Using co immunoprecipitation , it was shown that dimeric beta 2GPI can interact with apolipoprotein E receptor 2 ( apoER 2 ' ) , a member of the low density lipoprotein receptor family present on platelets . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| In developing mammalian ( mouse ) brain , Reelin ( Reln ) is secreted by the Cajal Retzius ( CR ) neurons in the marginal zone , binds apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( Vldlr ) , and induces the phosphorylation of the downstream cytoplasmic molecule disabled 1 ( Dab 1 ) in cortical plate neurons . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| The Reelin signaling pathway controls neuronal positioning during mammalian brain development by binding to the very low density lipoprotein receptor and apolipoprotein E receptor 2 , and signaling through the intracellular adapter protein Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Reelin is a large secreted signaling protein that binds to two members of the low density lipoprotein receptor family , the apolipoprotein E receptor 2 and the very low density lipoprotein receptor , and regulates neuronal positioning during brain development . ^^^ Because the Dab 1 phosphotyrosine binding domain can interact simultaneously with membrane lipids and with the intracellular domains of apolipoprotein E receptor 2 and very low density lipoprotein receptor , Dab 1 is preferentially recruited to the neuronal plasma membrane , where it is phosphorylated . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Differential binding of ligands to the apolipoprotein E receptor 2 . ^^^ Apolipoprotein E receptor 2 ( apoER 2 ) is an important participant in the Reelin signaling pathway that directs cell positioning during embryogenesis . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Inhibin beta A , apolipoprotein E receptor 2 , MAPK kinase kinase 5 ( ask 1 ) , and carboxypeptidase D were isolated and verified to be reliable markers for dominant follicles using real time RT PCR . ^^^ Before the time point at which dominant follicles can be distinguished by virtue of their deviation in size and growth rate , transcripts for inhibin beta A , apolipoprotein E receptor 2 , and p 450 aromatase were elevated specifically in the one to three largest follicles . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Reelin binding to apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) leads to phosphorylation of disabled 1 ( Dab 1 ) , an adaptor protein which associates with the intracellular domains of both receptors . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| The Reelin signaling pathway in the brain involves the binding of Reelin to very low density lipoprotein receptors ( VLDLR ) and apolipoprotein E receptor 2 ( ApoER 2 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Unlike layer formation , neuromuscular junction development requires a function of Reelin that is not mediated by Disabled 1 or very low density lipoprotein receptors and apolipoprotein E receptor 2 receptors but by a distinct mechanism involving its protease activity . . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Apolipoprotein E receptor 2 is involved in neuritic plaque formation in APP sw mice . ^^^ Apolipoprotein E receptor 2 ( apoER 2 ) is a receptor for apolipoprotein E containing lipoprotein and also for Reelin . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Binding of low density lipoprotein to platelet apolipoprotein E receptor 2 ' results in phosphorylation of p38MAPK . ^^^ Confocal microscopy revealed a high degree of co localization of LDL and a splice variant of the LDL receptor family member apolipoprotein E receptor 2 ( apoER 2 ' ) at the platelet surface , suggesting that apoER 2 ' may contribute to LDL induced platelet signaling . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| The LDL receptor related protein 5 ( LRP 5 ) is a member of the LDL receptor family , which also includes the VLDL receptor and the apolipoprotein E receptor 2 . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Reelin , very low density lipoprotein receptor , and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro . ^^^ Reelin binds several receptors , including two members of the low density lipoprotein ( LDL ) receptor family , the apolipoprotein E receptor 2 ( ApoER 2 ) and the very low density lipoprotein receptor ( VLDLR ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| We found that apolipoprotein E receptor 2 ' ( apoER 2 ' ) , a member of the low density lipoprotein receptor family , is involved in activation of platelets by dimeric beta ( 2 ) GPI . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| The apolipoprotein E receptor 2 ( apoER 2 ) is a member of the low density lipoprotein receptor family which binds ligands such as reelin , apolipoprotein E and apolipoprotein J / clusterin and has been shown to play roles in neuronal migration during development and in male fertility . ^^^ Apolipoprotein E receptor 2 partitions into lipid rafts and interacts with caveolin 1 , a feature that could modulate its endocytic behavior . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Apolipoprotein E receptor 2 ( Apoer 2 ) , a member of the LDL receptor gene family , and its ligand Reelin control neuronal migration during brain development . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Reelin , a large protein that regulates neuronal migration during embryonic development , activates a conserved signaling pathway that requires its receptors , very low density lipoprotein receptor and apolipoprotein E receptor 2 , the cytoplasmic adaptor protein Disabled 1 ( Dab 1 ) , and Src family kinases ( SFK ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Apolipoprotein E receptor 2 interactions with the N methyl D aspartate receptor . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Here we studied whether Reelin from other brain regions can similarly induce this rescue effect and whether it is mediated via the Reelin receptors apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Functional dissection of Reelin signaling by site directed disruption of Disabled 1 adaptor binding to apolipoprotein E receptor 2 : distinct roles in development and synaptic plasticity . ^^^ Reelin signals by binding to two transmembrane receptors , apolipoprotein E receptor 2 ( Apoer 2 ) and very low density lipoprotein receptor . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Whereas the LDL receptor represents the archetype of an endocytic lipoprotein receptor , the structurally closely related apolipoprotein E receptor 2 ( apoER 2 ) and very low density lipoprotein ( VLDL ) receptor activate a kinase dependent intracellular signaling cascade after binding to the neuronal signaling molecule Reelin . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Genetic evidence suggests that interpretation of the Reelin signal by migrating neurons involves two neuronal cell surface proteins , the very low density lipoprotein receptor ( VLDLR ) and the apoE receptor 2 ( ApoER 2 ) as well as a cytosolic adaptor protein , Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Mice that are mutant for Reelin or Dab 1 , or doubly mutant for the VLDL receptor ( VLDLR ) and ApoE receptor 2 ( ApoER 2 ) , show disorders of cerebral cortical lamination . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| In addition to LDLR , mammalian members of this family include the LDLR related protein ( LRP ) , the very low density lipoprotein receptor ( VLDLR ) , the apolipoprotein E receptor 2 ( apoER 2 ) , and megalin . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Apolipoprotein E ( apoE ) is known to bind to at least five receptors , including the low density lipoprotein ( LDL ) receptor related protein ( LRP ) , very low density LDL receptor ( VLDL R ) , LDL R , apoE receptor 2 ( apoER 2 ) , and megalin / gp330 . ^^^ Apolipoprotein E ( apoE ) is known to bind to at least five receptors , including the low density lipoprotein ( LDL ) receptor related protein ( LRP ) , very low density LDL receptor ( VLDL R ) , LDL R , apoE receptor 2 ( apoER 2 ) , and megalin / gp330 . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Two apolipoprotein E ( apoE ) receptors , the very low density lipoprotein ( VLDL ) receptor and apoE receptor 2 ( apoER 2 ) , are also receptors for Reelin , a signaling protein that regulates neuronal migration during brain development . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Performance of multiple genetic analyses ( single nucleotide polymorphism detection , gene expression profiling , and splicing isoform detection ) on a single electronic microarray was demonstrated using the ApoE and ApoER 2 genes as a model system . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Specialized neurons throughout the developing central nervous system secrete Reelin , which binds to ApoE receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) , triggering a signal cascade that guides neurons to their correct position . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Mice lacking Reelin ( Reln ) , double knockouts lacking the VLDL receptor ( VLDLR ) and ApoE receptor 2 ( ApoER 2 ) , and mice lacking disabled 1 ( Dab 1 ) display increased levels of phosphorylated tau . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| The low density lipoprotein ( LDL ) receptor family comprises several proteins with similar structures including the LDL receptor and apoE receptor 2 ( apoER 2 ) . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol ( PI ) 3 kinase inhibitors suppressed the apoE effect , while apoE receptor 2 ( apoER 2 ) was tyrosine phosphorylated . ^^^ We conclude that apoE stimulates endothelial nitric oxide release in an isoform dependent manner , and propose that tyrosine phosphorylation of apoER 2 initiates PI 3 kinase signalling and activation of nitric oxide synthase . . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| The apolipoprotein E ( apoE ) receptor 2 ( apoER 2 ) , another member of the LDL receptor family with functions in cellular signal transmission , also undergoes sequential proteolytic processing , resulting in intracellular domain release into the cytoplasm . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| We have studied the contribution of the carboxy terminal domains of lipid free apoE isolated from apoE expressing cell cultures in binding to phospholipids and have determined the affinities of reconstituted POPC apoE particles for the apoER 2 . ^^^ POPC apoE particles generated using apoE 3 , apoE 4 , the truncated apoE 4 259 , apoE 4 229 , apoE 4 202 , and apoE 165 , and the mutant apoE4R158M all bound tightly to the apoER 2 ( K ( d ) range of 12 + / 3 to 19 + / 4 microg / mL ) . ^^^ The findings establish that the apoER 2 binding domain of apoE is in the 1 165 amino terminal region , whereas the carboxy terminal 230 299 region of apoE is required for efficient initial association with phospholipids . . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Binding of Reelin to the neuronal apolipoprotein E receptors apoER 2 and very low density lipoprotein receptor induces tyrosine phosphorylation of Dab 1 and the subsequent activation or relocalization of downstream targets like phosphatidylinositol 3 ( PI 3 ) kinase and Nckbeta . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Moreover , by RT PCR , we show that both reelin receptors ( namely apolipoprotein E receptor [ ApoER 2 ] , very low density lipoprotein receptor [ VLDLR ] and cadherin related neuronal receptor [ CNR ] ) and the cytoplasmic adapter Disabled 1 implicated in the reelin signal transduction , were expressed by trigeminal ganglion . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| The apoE receptor apoER 2 is involved in the maintenance of efficient synaptic plasticity . ^^^ ApoER 2 is one of the major receptors for ApoE in the brain , and has been shown to be involved not only in lipoprotein endocytosis , as other members of the LDL receptor family of receptors , but also in various cellular functions such as signalling and cellular guidance . ^^^ Our results indicate that animals lacking apoER 2 express higher levels of brain APP , as well as both key amyloid peptides , while apoE levels are slightly lower . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Expression of apoE receptor 2 ( apoER 2 ) , a known signalling receptor in brain , was readily detected in SH SY 5Y and CCF STTG 1 cells , common models of neurons and astrocytes , respectively , and was highest in H 4 neuroglioma , NT 2 precursor cells and IMR 32 neuroblastoma cells . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Two brain receptors for apolipoprotein E ( apoE ) , the apoE receptor 2 ( apoEr 2 ) and the very low density lipoprotein receptor ( VLDLr ) , are important in neuronal migration during development . ^^^ ApoE binding to these receptors caused increased release of the extracellular domain and accumulation of the intracellular domains ; similar increases in receptor proteolytic domains were observed from endogenous apoEr 2 after treatment of primary neurons or rat hippocampus with an apoE derived peptide . ^^^ The human apoE isoforms promoted proteolysis to different degrees , with apoE 2 resulting in a greater accumulation of the C terminal fragments of apoEr 2 compared with apoE 4 . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Through coimmunoprecipitation experiments , we demonstrated that F spondin interacts with an apoE receptor ( apoE receptor 2 [ ApoEr 2 ] ) through the thrombospondin domain of F spondin and the ligand binding domain of ApoEr 2 . ^^^ F spondin interaction with the apolipoprotein E receptor ApoEr 2 affects processing of amyloid precursor protein . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| FE 65 interaction with the ApoE receptor ApoEr 2 . ^^^ Our previous data demonstrate that the apoE receptor ApoEr 2 co precipitated with APP and suggest that there are extracellular and intracellular interactions between these two transmembrane proteins . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis of cytoplasmic LRP 8 revealed several peptide motifs with potential for cellular signaling and we propose this as a rational mechanism through which apoE inhibits platelet aggregation . . ^^^ |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14114 and P02649 |
Pubmed |
SVM Score :0.0 |
| NA |
|