| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.55320954 |
| We investigated whether a previously reported human lymphokine , lymphocyte chemoattractant factor ( LCF ) , which was described for its effects on human CD4+ lymphocytes and monocytes , could associate directly with CD 4 and induce the generation of second messengers . 0.55320954^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.55095499 |
| LCF binds to CD 4 and has previously been found to stimulate migration of CD4+ lymphocytes and monocytes . 0.55095499^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| To determine if the natural CD 4 ligand interleukin 16 also induces unresponsiveness , we tested the effects of rIL 16 on T cell proliferation in mixed lymphocyte reactions . rIL 16 suppressed T cell proliferation in a dose dependent manner at concentrations of 10 ( 11 ) to 10 ( 7 ) M . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Interleukin 16 and its function as a CD 4 ligand . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Regulation of the serine base exchange enzyme system by CD 4 : effects of monoclonal antibodies , jacalin , interleukin 16 and the HIV membrane protein gp 120 . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Interleukin 16 is secreted from a variety of immune cells as a peptide of 17 kDa which aggregates into tetrameric form essential for IL 16s direct interaction with and cross linking of its receptor , the CD 4 antigen . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Interleukin 16 ( IL 16 ) is a chemotactic cytokine that binds to the CD 4 receptor and affects the activation of T cells and replication of HIV . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Recombinant interleukin 16 ( rIL 16 ) has been found to inhibit human immunodeficiency virus type 1 ( HIV 1 ) replication in acutely or endogenously infected CD 4 ( + ) T cells . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Identification of a CD 4 domain required for interleukin 16 binding and lymphocyte activation . ^^^ Interleukin 16 ( IL 16 ) activates CD 4 ( + ) cells , possibly by direct interaction with CD 4 . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Interleukin 16 ( IL 16 ) , a natural ligand for the CD 4 receptor , has been found to modulate T lymphocyte function and to inhibit human immunodeficiency virus type 1 ( HIV 1 ) replication . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Interleukin 16 is a soluble ligand to the CD 4 molecule with chemotactic properties for CD4+ cells and a competence growth factor for CD4+ T cells , upregulating HLA DR and the interleukin 2 receptor CD 25 . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| These results indicate that treatment with peptide 3 causes the same effects as do antibodies to interleukin 16 , possibly via the inhibition of interaction between interleukin 16 and its receptor CD 4 . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Interleukin 16 : implications for CD 4 functions and HIV 1 progression . ^^^ Interleukin 16 is a ligand for CD 4 , and this implies CD 4 acts as a sentinel receptor that can switch CD4+ T cells between immune and inflammatory functions . . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| We attempted to find the immunosuppressive protocol for prolonging skin allograft rejection by using interleukin 16 because IL 16 is considered one of the natural ligands to CD 4 molecules . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| First , we compared quantitative competitive RT PCR with real time RT PCR in the quantitation of transcription levels of the CD 4 ( + ) cell specific chemoattractant Interleukin 16 during the maturation of monocyte derived dendritic cells , and found a good correlation between both methods . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Interleukin 16 ( IL 16 ) is a chemotactic cytokine which binds to CD 4 and affects T cell activation . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Interaction between human interleukin 16 and CD 4 receptor of HIV 1 . ^^^ AIM : To study the interaction between human interleukin 16 ( IL 16 ) and the receptor CD 4 ( T lymphocyte differentiation antigen ) of human immunodeficiency virus type 1 ( HIV 1 ) . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Interleukin 16 ( IL 16 ) acts highly chemotactic on CD 4 bearing cells . ^^^ CONCLUSIONS : Interleukin 16 was mainly expressed in a typical CD 4 like pattern in human tonsils . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| The ability of costimulated CD 8 cells to respond to interleukin 16 ( IL 16 ) , a ligand that binds CD 4 and induces cellular chemotaxis , was examined . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| The first of these , interleukin 16 , is an immunomodulatory cytokine involved in the regulation of CD 4 T cells . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| MIP 1beta induced G protein activation was further increased by simultaneous stimulation of CD 4 with its natural agonist , interleukin 16 . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Mo and AM were separately exposed to the three PM size fractions and supernatants assessed for the T helper ( CD 4 ( + ) ) lymphocyte chemoattractant interleukin 16 ( IL 16 ) . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Here we show that these effects of CD 4 ligation were not observed when anti CD 4 antibody was replaced with another CD 4 ligand , interleukin 16 , or when the anti CD 3 and anti CD 4 antibodies were spatially separated by immobilization on different beads . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| A T cell derived cytokine , lymphocyte chemoattractant factor ( LCF ) , which stimulates the migration and function of CD4+ lymphocytes and eosinophils , also utilizes CD 4 expressed on human eosinophils as its receptor . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| These LCF induced events demonstrate an absolute requirement for the cell surface expression of CD 4 . ^^^ Because many CD 4 mediated T lymphocyte activation events have been demonstrated to require the association of the src related tyrosine kinase p56lck with the cytoplasmic domain of CD 4 , we examined the role of p56lck in LCF induced lymphocyte migration in a murine T cell hybridoma line expressing transfected human CD 4 . ^^^ LCF induces the catalytic activity of CD 4 associated p56lck at chemoattractant concentrations of cytokine . ^^^ Hybridoma cells that express CD 4 with cytoplasmic point mutations which uncouple the CD 4 lck association lack both lck enzymatic activity and chemotactic responses to LCF . ^^^ Second , T cell hybridomas expressing a chimeric receptor combining the extracellular domain of human CD 4 and murine p56lck which lacked the kinase domain had a normal LCF induced motile response . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| LCF ' s activity on CD 4 cells defines a role for CD 4 on the eosinophil and monocyte and broadens the scope of functions of CD 4 on the T cell . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| There is an absolute requirement for both autoaggregation of LCF monomers and for membrane expressed CD 4 molecules for LCF induced migration in lymphocytes . . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| The leukocyte chemotactic factor ( LCF ) is a proinflammatory cytokine and natural soluble ligand to the human CD 4 molecule . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Microglial cells were visualized by immunolabeling of proteins which are known to be expressed either constitutively or facultatively , such as CD 68 , major histocompatibility complex class 2 ( MHC 2 ) , leukocyte common antigen ( LCA ) , leukocyte chemotactic factor ( LCF ) , macrophage inhibitory factor related protein ( MRP ) 8 , MRP 14 , CD 4 and allograft inflammatory factor 1 ( AIF 1 ) . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| Recently , interleukin ( IL ) 16 ( lymphocyte chemoattractant factor ) was reported to be a potent chemotactic stimulus for CD 4 ( + ) T lymphocytes and eosinophils , the types of leukocyte found in the proximity of bronchial epithelium in asthmatic individuals . ^^^ |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14005 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|