| Interacting proteins: Q13887 and Q01105 |
Pubmed |
SVM Score :0.0 |
| Positive and negative regulation of the cardiovascular transcription factor KLF 5 by p 300 and the oncogenic regulator SET through interaction and acetylation on the DNA binding domain . ^^^ The oncogenic regulator SET was isolated by affinity purification of factors interacting with the DBD of the cardiovascular transcription factor KLF 5 . ^^^ SET negatively regulated KLF 5 DNA binding , transactivation , and cell proliferative activities . ^^^ Down regulation of the negative regulator SET was seen in response to KLF 5 mediated gene activation . ^^^ Interestingly , SET inhibited KLF 5 acetylation , and a nonacetylated mutant of KLF 5 showed reduced transcriptional activation and cell growth complementary to the actions of SET . ^^^ |
|
| Interacting proteins: Q13887 and Q01105 |
Pubmed |
SVM Score :0.0 |
| Recently , we have shown that Krppel like factor KLF 5 , a member of the Sp / KLF family of zinc finger factors and a key regulator of cardiovascular remodeling , is regulated positively by the acetylase p 300 and negatively by the oncogenic regulator SET through coupled interaction and regulation of acetylation . ^^^ |
|
| Interacting proteins: Q13887 and Q01105 |
Pubmed |
SVM Score :0.0 |
| KLF 5 activities are regulated by many transcriptional regulators and nuclear receptors , such as retinoic acid receptor alpha ( RAR alpha ) , NF kappaB , PPAR gamma , p 300 , and SET . ^^^ |
|
| Interacting proteins: Q13887 and Q01105 |
Pubmed |
SVM Score :0.0 |
| NA |
|