| Interacting proteins: Q13887 and P19838 |
Pubmed |
SVM Score :0.58934483 |
| Interestingly , the nuclear factor kappaB ( NF kappaB ) p 50 subunit further cooperatively activates PDGF A chain through protein protein interaction with KLF 5 but not Egr 1 . 0.58934483^^^ |
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| Interacting proteins: Q13887 and P19838 |
Pubmed |
SVM Score :0.0 |
| Overexpression of KLF 5 leads to an increase in the TPA response from VLTRE , a TPA inducible enhancer element that shows keratinocyte specificity with respect to Rel / NF kappaB binding . ^^^ The KLF 5 mediated transcriptional increase is not observed in the presence of overexpressed NF kappaB inhibitor , IkappaBalpha . ^^^ Cotransfection of KLF 5 and the p 65 subunit of NF kappaB , results in a synergistic transactivation of the VLTRE luciferase reporter . ^^^ Considering the TPA responsiveness and expression pattern , we propose that KLF 5 like another member of its family KLF4 / GKLF may play an important role in skin morphogenesis and carcinogenesis potentially via its interaction with NF kappaB factors . . ^^^ |
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| Interacting proteins: Q13887 and P19838 |
Pubmed |
SVM Score :0.0 |
| KLF 5 activities are regulated by many transcriptional regulators and nuclear receptors , such as retinoic acid receptor alpha ( RAR alpha ) , NF kappaB , PPAR gamma , p 300 , and SET . ^^^ |
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| Interacting proteins: Q13887 and P19838 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with the MAPK inhibitor , U 0126 , or the LPS antagonist , polymyxin B , resulted in an attenuation of KLF 5 , p 50 and p 65 NF kappaB subunit mRNA levels from LPS treatment . ^^^ Importantly , suppression of KLF 5 by small interfering RNA ( siRNA ) resulted in a reduction in p 50 and p 65 subunit mRNA levels and NF kappaB DNA binding activity in response to LPS . ^^^ |
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