| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Receptor binding studies of CDMP 1 and CDMP 2 revealed that both have affinity for the BMP receptor type IB ( BMPR IB ) and BMPR 2 , and weakly for BMPR IA . ^^^ Moreover , using a promoter / reporter construct , transcriptional activation signal was transduced by BMPR IB in the presence of BMPR 2 upon CDMP 1 and CDMP 2 binding . ^^^ |
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| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| GDF 5 induced alkaline phosphatase activity in a rat osteoprogenitor like cell line , ROB C 26 . 125I GDF 5 bound to BMPR IB and BMPR 2 but not to BMPR IA in ROB C 26 cells and other nontransfected cell lines . ^^^ When COS 1 cells were transfected with type 2 receptor cDNAs , GDF 5 bound to ActR 2 , ActR IIB , and BMPR 2 but not to transforming growth factor beta type 2 receptor . ^^^ Moreover , a transcriptional activation signal was efficiently transduced by BMPR IB in the presence of BMPR 2 or ActR 2 after stimulation by GDF 5 . ^^^ These results suggest that BMPR IB mediates certain signals for GDF 5 after forming the heteromeric complex with BMPR 2 or ActR II . . ^^^ |
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| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| GDF 5 bound to ALK 6 / BMPR IB and BMP type 2 receptor ( BMPR 2 ) but not to ALK 3 / BMPR IA in ROB C 26 cells . ^^^ When COS 1 cells were transfected with type 2 receptor cDNAs , GDF 5 bound to Activin type 2 receptor ( ActR 2 ) and type IIB receptors as well as BMPR 2 but not to TGF beta type 2 receptor . ^^^ Moreover , GDF 5 transduced the signal efficiently by ALK 6 / BMPR IB in the presence of BMPR 2 or ActR II . . ^^^ |
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| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Disc cells expressed the receptors BMPR1A , BMPR1B , and BMPR 2 , which are relevant for GDF 5 action . ^^^ |
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| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| GDF 5 ( growth and differentiation factor five ) , a member of the TGF beta superfamily , binds specifically to BMPR1b , BMPR 2 and ACTR2a receptors forming a heterodimeric complex , thereby inducing phosphorylation of smad 1 , 5 , 8 and translocation to the nucleus . ^^^ |
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| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43026 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|