Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.95174309
In reference to our previous study of BMP type 1 receptors ( BMPR IA and BMPR IB ) , BMPR 2 was found to be co localized with BMPR IA and BMPR IB . 0.95174309^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.55272433
In contrast , binding of BMP 6 to BMPR IB ( ALK 6 ) , and less efficiently to ALK 2 and BMPR IA , together with BMPR 2 was detected in ROB C 26 cells . 0.55272433^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Immunolabeling of pituitary sections revealed the presence of BMPR IA ( ALK 3 ) and BMPR 2 in gonadotrope cells . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
OP 1 / BMP 7 binds to BMPR 2 and ActR 2 and forms complexes with BMPR IA and IB and ActR 1 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
C2C12 cells expressed BMPR IA and BMPR 2 mRNAs , but not BMPR IB mRNA at detectable levels in Northern blotting . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
BMPR IA and BMPR 2 were immunolocalized from days 4 to 10 after ablation , and became negative on days 21 and 28 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
However , expression of BMPR IA and BMPR 2 messenger RNA ( mRNA ) was detected by Northern blot analysis . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Disc cells expressed the receptors BMPR1A , BMPR1B , and BMPR 2 , which are relevant for GDF 5 action . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Here , we describe the pattern of expression of BMP receptors , including Bmpr Ia , Bmpr Ib , Bmpr 2 , Actr 1 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
We observed the expression of BMPR1a , BMPR1b , BMPR 2 , ACTR2a , smad 1 , smad 5 , ID 1 , ID 2 and ID 3 in HUVSMC . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
We analyzed poly ( A ) + RNA from rat incisor pulp and bovine adult pulp by reverse transcriptase / polymerase chain reaction ( RT PCR ) , using a degenerate primers corresponding to the most conserved amino acid sequences in the intracellular serine / threonine kinase of type 1 or type 2 like kinase 1 ( ALK 1 ) , ALK 2 , ALK 3 ( bone morphogenetic protein receptor type IA , BMPR IA ) , ALK 4 ( B 1 ) , ALK 5 , ALK 6 ( BMPR IB ) , and BMPR 2 ( BMP type 2 receptor ) was found to be in dental pulp . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
To explore the molecular cascade of odontoblast differentiation , Northern blot analyses and reverse transcriptase polymerase chain reaction were here used to investigate the expression patterns of the genes for TGF beta superfamily members : TGF beta 1 , namely bone morphogenetic protein ( BMP ) 4 , BMP 7 , activin beta A and activin beta B , and their type 1 and type 2 receptors , namely activin receptor like kinase ( ALK ) 2 ( ActR 1 ) , ALK 3 ( BMPR IA ) , ALK 4 ( ActR IB ) , ALK 5 ( T beta R 1 ) , BMPR 2 and T beta R 2 , during differentiation of pulp cells into preodontoblasts in bovine adult pulp cell culture . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Activin A bound to ActR IB / ALK 4 and ActR 2 , and BMP 7 bound to ActR I / ALK 2 , BMP type 1 receptor ( BMPR 1 ) / ALK 3 , ActR 2 and BMPR 2 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Together , our results demonstrate that BMP signaling is required for maintenance of XNkx 2 5 expression and heart formation and suggest that ALK 3 , BMPRII , and XSmad 1 may mediate this signaling . . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
The BMP 4 transcripts were expressed in all stages of differentiation , as were transcripts for BMP type IA receptor ( ALK 3 ) and BMP type 2 receptor . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Messenger RNAs for BMP 2 , 4 , 7 , the BMP type 1 receptors Act R 1 ( alk 2 , activin like kinase receptor ) , BMPR IA ( alk 3 ) , IB ( alk 6 ) , and the type 2 receptor BMPR 2 were detected . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) demonstrated the presence of various BMPs ( BMP 2 , 3 , 4 , 6 , 7 , and 8A and 8B ) , BMP type 1 and 2 receptors ( ALK 2 , ALK 3 , ALK 4 , BMPR 2 , and ActR IIA and IIB ) , BMP antagonists ( DAN , gremlin , chordin , cerberus , noggin , and tsg ) , and Smads 1 8 . mRNA expression of these genes did not change during differentiation , except for BMP 3 , BMP 8a , and noggin . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
In this study we examine the spatio temporal expression patterns of activin receptors ( ActRIIA , ActRIIB , ALK 1 , and ALK 2 ) , BMP receptors ( BMPRII , ALK 3 , and ALK 6 ) , and the distribution of the phosphorylated forms of Smad 1 and Smad 2 during normal lens development ( E 12 P21 ) and aberrant development in transgenic mice that express dominant negative TGFbeta receptors . ^^^ RESULTS : RT PCR of RNA from postnatal lenses showed distinct expression of ActRIIA , ActRIIB , BMPRII , and ALK 3 but not ALK 1 , ALK 2 , or ALK 6 . ^^^ In situ hybridization with specific probes for BMPRII , ActRII , and ALK 3 showed ubiquitous expression in ectoderm , lens pit , optic vesicle , and peri optic mesenchyme during early lens formation at E 12 . ^^^ Further investigation of the expression of these receptors in lenses of transgenic mice , which ectopically express a truncated TbetaRII , showed marked up regulation and aberrant expression of ALK 3 , but not BMPRII or ActRII . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
BMP type 1 receptors , including activin receptor like kinase 2 ( ALK 2 ) ( also referred to as ActRIA ) and ALK 3 ( BMPRIA ) , both type 2 receptors , ActRII and BMPRII , as well as the ligands BMP 2 , 4 , and 7 and inhibin / activin subunits were expressed in PC 12 cells . ^^^ Furthermore , intracellular BMP signaling was markedly suppressed by dexamethasone treatment and the expression of ALK 2 , ALK 3 , and BMPRII was significantly inhibited by dexamethasone . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
GDF 9 and BMPs initiate signaling by assembling type 1 ( ALK 3 , ALK 5 and ALK 6 ) and type 2 ( BMPRII ) receptors . ^^^ The aim of the present study was to clarify the involvement of receptor systems for GDF 9 and BMPs in follicular selection by examining the effects of FSH and estradiol 17beta ( E 2 ) on the regulation of BMPRII , ALK 3 , ALK 5 and ALK 6 mRNA expression in bovine granulosa cells ( GCs ) . ^^^ Total RNA was extracted and the mRNA expression of BMPRII , ALK 3 , ALK 5 and ALK 6 was estimated by the quantitative real time PCR method using a LightCycler . ^^^ BMPRII and ALK 5 expression was significantly higher in the GCs of POFs than in those of PRFs , whereas ALK 3 expression was significantly lower in the GCs of POFs than in those of PRFs . ^^^ The expression of BMPRII , ALK 5 , ALK 3 and ALK 6 genes in the TCs was not significantly different between PRFs and POFs . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Furthermore , we demonstrated the roles of BMPRII , ALK 3 and ALK 6 as the receptors for the orphan ligands GDF 6 , GDF 7 and BMP 10 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
In this report , we show that the osteoinductive effects of BMP 2 in C2C12 cells are mediated by bone morphogenetic protein receptor type IA in combination with both activin receptor type 2 and bone morphogenetic protein receptor type 2 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Bone morphogenetic protein receptor type 2 is a receptor for growth differentiation factor 9 . ^^^ Addition of bone morphogenetic protein receptor type 2 ( BMPRII ) ectodomain was most effective in blocking GDF 9 stimulation of granulosa cell proliferation and GDF 9 suppression of FSH stimulated progesterone production . ^^^ In addition , the ectodomains of bone morphogenetic protein receptor type IA , bone morphogenetic protein receptor type IB , and activin receptor type IIA were partially effective in blocking GDF 9 action . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Mutations in the bone morphogenetic protein receptor type 2 ( BMPR 2 ) have been linked to familial cases of pulmonary hypertension , but the molecular basis of the common nonfamilial forms is unknown . ^^^ METHODS : We evaluated the pattern of expression of angiopoietin 1 , a protein involved in the recruitment of smooth muscle cells around blood vessels ; TIE 2 , the endothelial specific receptor for angiopoietin 1 ; and bone morphogenetic protein receptor type 1A ( BMPR1A ) and BMPR 2 in lung biopsy specimens from patients with pulmonary hypertension and from normotensive control patients . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
BMP 4 binds to two different type 1 receptors , BMP receptors type IA ( BMPR IA ) and type IB ( BMPR IB ) , and a type 2 receptor , BMP receptor type 2 ( BMPR 2 ) . ^^^ GDF 5 induced alkaline phosphatase activity in a rat osteoprogenitor like cell line , ROB C 26 . 125I GDF 5 bound to BMPR IB and BMPR 2 but not to BMPR IA in ROB C 26 cells and other nontransfected cell lines . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
The recently cloned bone morphogenetic factor receptor type 2 ( BMPR 2 ) was compared with the ActR 2 and several type 1 receptors including ActR 1 , ActR IB , BMPR IA , BMPR IB and TbetaR 1 . ^^^ At E 15 , the expression of ActR 2 mRNA was stronger than that of BMPR 2 in the spinal cord , followed in intensity by the expression of ActR 1 , ActR IB , BMPR IA , BMPR IB and TbetaR 1 mRNA . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
By contrast , the mRNA levels of BMPR IA and BMPR 2 were not significantly different among non cancerous and cancerous prostate tissues . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
The expression patterns of the type 2 BMP receptor ( BMPR 2 ) and three type 1 BMP receptors ( ActR 1 , BMPR IA and BMPR IB ) were examined in preimplantation embryos by means of heminested reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ BMPR 2 , BMPR IA and BMPR IB mRNAs were also detected in undifferentiated and differentiated embryonal carcinoma and embryonic stem cells . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
We have reported previously that BMPR IB mRNA expression is highest in the prostate , a characteristic that is not shared by the other BMPRs , BMPR IA and BMPR 2 . ^^^ Semiquantitative RT PCR showed that BMPR IB mRNA was induced by androgen in the androgen sensitive human prostatic cancer cell line LNCaP , whereas the expression of BMPR IA and BMPR 2 mRNAs was not affected by androgen . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Receptor binding studies of CDMP 1 and CDMP 2 revealed that both have affinity for the BMP receptor type IB ( BMPR IB ) and BMPR 2 , and weakly for BMPR IA . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
In this study , in situ hybridization analyses demonstrate that BMP specific type 1 ( BMPR IA and BMPR IB ) and type 2 ( BMPR 2 ) receptor mRNAs are expressed at significant levels in multiple regions of the CNS , cranial ganglia , and peripheral sensory and autonomic ganglia during the embryonic and neonatal periods . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Immunohistochemical analysis demonstrated that cells expressing either BMP 2 / 4 or their receptors ( BMPR IA , BMPR IB , and BMPR 2 ) preferentially appeared in nodules . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
In this study , we studied immunohistochemically the spatial and temporal localization of BMP 2 / 4 , osteogenic protein 1 ( OP 1 , or BMP 7 ) , and BMP receptors ( BMPR IA , BMPR IB , and BMPR 2 ) in the epiphyseal plate of growing rats . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
In the present study , mRNAs for three BMP subtype 1 receptors ( ActR 1 , BMPR IA , and BMPR IB ) and one BMPR 2 receptor were detected by Northern analysis in two human osteosarcoma cell lines ( SaOS 2 and TE 85 ) and in the primary cultures of fetal rat calvaria ( FRC ) cells . ^^^ The present results suggest that the ActR 1 , BMPR IA , and BMPR IB receptors and the BMPR 2 receptor are expressed and functional for OP 1 in FRC cells and that regulation of synthesis of these receptors may be a mechanism by which a specific cell type responds to OP 1 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
METHODS : Transcription of bone morphogenetic proteins ( BMP ) 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 ; growth differentiation factor ( GDF ) 5 ) , and BMP receptors ( BMPR ) types 1 ( BMPR IA , BMPR IB ) and 2 ( BMPR 2 ) was investigated by reverse transcription polymerase chain reaction ( RT PCR ) in ex vivo and cultured cells . ^^^ RESULTS : Transcription of BMP 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 and receptors of BMPR IA , BMPR IB and BMPR 2 was detected in ex vivo and cultured epithelium and stroma . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
BMP signaling occurs via hetero oligomeric serine / threonine kinase complexes of BMP type 1 ( BMPR IA or BMPR IB ) and type 2 receptors ( BMPR 2 ) . ^^^ Using somatic cell hybrid and FISH analyses , the BMPR1A , BMPR1B , and BMPR 2 genes were assigned to 10q23 , 4q22 24 , and 2q33 34 , respectively . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Among prostate cancer specimens , well differentiated cancers were positive for the expression of BMPR 2 , BMPR IA , and BMPR IB , for the most part . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
The binding epitopes of BMP 2 for BMPR IA ( type 1 ) and BMPR 2 or ActR 2 ( type 2 ) were characterized using BMP 2 mutant proteins for analysis of interactions with receptor ectodomains . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Reverse transcription polymerase chain reaction ( RT PCR ) analyses indicate that both upper and lower chondrocytes produce messenger RNA ( mRNA ) for all three receptors : BMPR type IA ( BMPR IA ) , BMPR type IB ( BMPR IB ) , and BMPR type 2 ( BMPR 2 ) . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
BMPs directly stimulate mature osteoclast function probably mediated by BMPR IA and BMPR 2 and their downstream molecules expressed in osteoclasts . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
In the present study , in situ hybridisation histochemistry was used to localise mRNAs for BMP type 1 receptors ( BMPR IA and BMPR IB ) and the BMP type 2 receptor ( BMPR 2 ) in developing mouse metanephroi . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
No expression was detected within PTEC ; however , these cells were found to express mRNA for BMP receptors including , ActR 1 , BMPR IA , ActR 2 , ActR IIB , and BMPR 2 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
BMPR 2 receptor mRNA expression in FRC cells treated with OP 1 and IL 6 plus IL 6sR was stimulated further , while BMPR IA , IB , and ActR 1 expressions were not affected . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
The sections were rehydrated , submitted to microwave antigen retrieval and treated with polyclonal antibodies against BMPR1A , BMPR1B and BMPR 2 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
With use of immunohistochemical analysis , we studied the localization of BMP 2 , BMP 4 , and BMP 7 and their receptors BMPR IA , BMPR IB , and BMPR 2 as well as pSmad 1 . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
In control cultures , the steady state mRNA levels of ActR 1 , BMPR IA , BMPR IB , and BMPR 2 increased as a function of time in culture . ^^^ OP 1 treatment stimulated mRNA expression of BMPR IA and BMPR 2 , but had little effect on ActR 1 and BMPR IB mRNA expression . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
The prevalence of MADH 4 and BMPR1A mutations in juvenile polyposis and absence of BMPR 2 , BMPR1B , and ACVR 1 mutations . ^^^ A total of 77 JP cases were sequenced for mutations in the MADH 4 , BMPR1A , BMPR1B , BMPR 2 , and / or ACVR 1 ( activin A receptor ) genes . ^^^ No mutations were found in BMPR1B , BMPR 2 , or ACVR 1 in 32 MADH 4 and BMPR1A mutation negative cases . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
METHODS : Dupuytren ' s fibroblasts and normal palmar fascia fibroblasts ( control ) were analyzed for messenger RNA expression of BMPs ( BMP 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 and 11 ) , their receptors ( BMPR IA , BMPR IB , and BMPR 2 ) , and their antagonists ( follistatin and noggin ) by reverse transcription polymerase chain reaction ( PCR ) . ^^^ RESULTS : With reverse transcription PCR the expression profile for normal palmar fascia fibroblasts versus Dupuytren ' s fibroblasts was found to show similar expression of BMP 1 and 11 ; qualitatively decreased expression of BMP 6 , BMP 8 , BMPR IA , BMPR IB , and BMPR 2 in Dupuytren ' s fibroblasts ; and no expression of BMP 4 in Dupuytren ' s fibroblasts . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
We studied the presence and distribution of growth differentiation factor 9 ( GDF 9 ) , bone morphogenetic protein 15 ( BMP 15 ) , and BMP receptors types 2 ( BMPR 2 ) , 1A ( BMPR1A ) , and 1B ( BMPR1B ) in goat ovaries to find evidence for their possible roles in folliculogenesis . ^^^ The mRNAs for GDF 9 , BMP 15 , BMPR 2 , BMPR1A , and BMPR1B were detected in primordial , primary , and secondary follicles as well as in oocyte and granulosa cells of antral follicles . ^^^ Transcripts for BMPR 2 , BMPR1A , BMPR1B , and GDF 9 , and GDF 9 protein were furthermore found in corpora lutea . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Severe pulmonary hypertension is associated with an increased expression of the angiogenic factor , angiopoietin 1 , which shuts off the expression of BMPR1A , a transmembrane protein necessary for BMPR 2 signalling , and thereby causes pulmonary artery smooth muscle cell proliferation . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Reverse transcription polymerase chain reaction studies with antral follicles showed the expression of BMPR IA , BMPR IB , ActR IA , ActR IIB , BMPR 2 and BMP 4 mRNA in all follicular compartments , while BMP 2 mRNA was generally restricted to theca and cumulus tissue . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Except at the late phase of treatment , CDMP treatment did not change the expression of ActR IA , BMPR IA , BMPR IB , BMPR 2 , and ALK 7 mRNAs . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
FSH administration upregulated BMP type IA ( BMPR1A ) and IB ( BMPR1B ) receptors , activin type 2 receptor ( ACVR 2 ) , and BMP type 2 receptor ( BMPR 2 ) . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
Here , we show the existence of mRNA for BMP 2 and for the BMP receptors BMPR1A , BMPR1B , BMPRII , ACVR1A , ACVR 2 , and ACVR2B in differentiated mouse podocytes and the protein expression of BMPR1A in human glomerular podocytes . ^^^
Interacting proteins: P36894 and Q13873 Pubmed SVM Score :0.0
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