| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| BMPR 2 is a transmembrane serine / threonine kinase that binds BMP 2 and BMP 7 in association with multiple type 1 receptors , including BMPR IA / Brk1 , BMPR IB , and ActR 1 , which is also an activin type 1 receptor . ^^^ BMP 2 and BMP 7 can induce a transcriptional response when added to cells coexpressing ActR 1 and BMPR 2 but not to cells expressing either receptor alone . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| To explore the molecular cascade of odontoblast differentiation , Northern blot analyses and reverse transcriptase polymerase chain reaction were here used to investigate the expression patterns of the genes for TGF beta superfamily members : TGF beta 1 , namely bone morphogenetic protein ( BMP ) 4 , BMP 7 , activin beta A and activin beta B , and their type 1 and type 2 receptors , namely activin receptor like kinase ( ALK ) 2 ( ActR 1 ) , ALK 3 ( BMPR IA ) , ALK 4 ( ActR IB ) , ALK 5 ( T beta R 1 ) , BMPR 2 and T beta R 2 , during differentiation of pulp cells into preodontoblasts in bovine adult pulp cell culture . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to determine the locations of BMP 2 / 4 , osteogenic protein 1 ( OP 1 , also termed BMP 7 ) , and BMP type 2 receptor ( BMPR 2 ) during rat fracture healing by immunostaining , and thereby elucidate the possible roles of the BMPs and BMPR 2 in intramembranous ossification and endochondral ossification . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| In this study , we studied immunohistochemically the spatial and temporal localization of BMP 2 / 4 , osteogenic protein 1 ( OP 1 , or BMP 7 ) , and BMP receptors ( BMPR IA , BMPR IB , and BMPR 2 ) in the epiphyseal plate of growing rats . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Endoglin did not interact with BMP 7 through complexes containing the BMP type 2 receptor , demonstrating specificity of its action . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| METHODS : Transcription of bone morphogenetic proteins ( BMP ) 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 ; growth differentiation factor ( GDF ) 5 ) , and BMP receptors ( BMPR ) types 1 ( BMPR IA , BMPR IB ) and 2 ( BMPR 2 ) was investigated by reverse transcription polymerase chain reaction ( RT PCR ) in ex vivo and cultured cells . ^^^ RESULTS : Transcription of BMP 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 and receptors of BMPR IA , BMPR IB and BMPR 2 was detected in ex vivo and cultured epithelium and stroma . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Activin A bound to ActR IB / ALK 4 and ActR 2 , and BMP 7 bound to ActR I / ALK 2 , BMP type 1 receptor ( BMPR 1 ) / ALK 3 , ActR 2 and BMPR 2 . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| The cells express mRNA for both BMP 6 and BMP 7 , as well as for the receptors BMPRIA and BMPRII , demonstrating that the postnatal cells have the ability to form the heterodimer receptors needed to respond to BMPs . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| With use of immunohistochemical analysis , we studied the localization of BMP 2 , BMP 4 , and BMP 7 and their receptors BMPR IA , BMPR IB , and BMPR 2 as well as pSmad 1 . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Disruption of Bmpr 2 leads to diminished signaling by BMP 2 and BMP 4 and augmented signaling by BMP 6 and BMP 7 . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| The mRNAs encoding BMP 2 , BMP 4 , BMP 7 and the oocyte derived growth factor , growth differentiation factor ( GDF ) 9 were detected in the pituitaries of cyclic ewes by reverse transcriptase PCR , as well as the mRNAs encoding the BMP type 1 receptors , BMPR IA ( activin receptor like kinase ( ALK ) 3 ) and BMPR IB ( ALK 6 ) , and type 2 receptors ( BMPR 2 ) . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Plasma glucose levels were measured before and after treatment and vascular gene expression of BMP 2 , BMP 7 , and BMP type 2 receptor was determined in the aorta by quantitative real time polymerase chain reaction analysis . ^^^ After 6 weeks gene expression of vascular BMP 2 , BMP 7 and BMP type 2 receptor was almost doubled in NOD mice compared with non diabetic controls ( p < 0 . 05 ) . ^^^ In conclusion , vascular BMP 2 , BMP 7 , and BMP type 2 receptor expression is upregulated in early stages of autoimmune diabetes mellitus . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Tissues were analyzed using immunohistochemistry for BMP ligand ( BMP 2 , BMP 4 , BMP 7 ) and receptor ( BMPRIA , BMPRIB , BMPRII ) expression . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| BMPR 2 expression and OP 1 effects in developing chicken retinal explants . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Biological activities of osteogenic protein 1 ( OP 1 ) , a documented ligand for BMPR 2 , were tested in explanted embryonic chicken ganglia and dissociated ganglionic neurons . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Inhibition of BMPR 2 synthesis reduced the OP 1 stimulated ALP activity by about 50 % . ^^^ Inhibition of synthesis of any one of the type 1 receptor plus the BMPR 2 receptor did not reduce the OP 1 stimulated ALP activity significantly beyond that observed by inhibition of BMPR 2 alone . ^^^ The present results suggest that the ActR 1 , BMPR IA , and BMPR IB receptors and the BMPR 2 receptor are expressed and functional for OP 1 in FRC cells and that regulation of synthesis of these receptors may be a mechanism by which a specific cell type responds to OP 1 . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Messenger RNA for BMP 2 , 4 , 7 ( OP 1 ) , the BMP type 1 receptors Act RI , BMPR 1A and 1B , the type 2 receptor BMPR 2 , and type 1 collagen were detected by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| OP 1 upregulated BMPR 2 mRNA expression by a maximum of 2 fold . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Further analysis by Western blotting indicated that an antibody raised against BMP type 2 receptor effectively recognized the 100 kD OP 1 binding component of kidney plasma membranes . ^^^ The major OP 1 binding component of the kidney appears to be a long form of BMP type 2 receptor with a Mr of 100 kD . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| BMPR 2 receptor mRNA expression in FRC cells treated with OP 1 and IL 6 plus IL 6sR was stimulated further , while BMPR IA , IB , and ActR 1 expressions were not affected . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| OP 1 treatment stimulated mRNA expression of BMPR IA and BMPR 2 , but had little effect on ActR 1 and BMPR IB mRNA expression . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Three type 2 receptors for BMPs have also been identified and they are type 2 BMP receptor ( BMPR 2 ) and type 2 and IIB activin receptors ( ActR 2 and ActR IIB ) ( Yamashita , H . et al . ( 1995 ) `` Osteogenic protein 1 binds to activin type 2 receptors and induces certain activin like effects ' ' , J . ^^^ |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18075 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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