| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Bone morphogenetic protein receptor type 2 is a receptor for growth differentiation factor 9 . ^^^ Addition of bone morphogenetic protein receptor type 2 ( BMPRII ) ectodomain was most effective in blocking GDF 9 stimulation of granulosa cell proliferation and GDF 9 suppression of FSH stimulated progesterone production . ^^^ In addition , the ectodomains of bone morphogenetic protein receptor type IA , bone morphogenetic protein receptor type IB , and activin receptor type IIA were partially effective in blocking GDF 9 action . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMPR 2 is a transmembrane serine / threonine kinase that binds BMP 2 and BMP 7 in association with multiple type 1 receptors , including BMPR IA / Brk1 , BMPR IB , and ActR 1 , which is also an activin type 1 receptor . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMP 4 binds to two different type 1 receptors , BMP receptors type IA ( BMPR IA ) and type IB ( BMPR IB ) , and a type 2 receptor , BMP receptor type 2 ( BMPR 2 ) . ^^^ GDF 5 induced alkaline phosphatase activity in a rat osteoprogenitor like cell line , ROB C 26 . 125I GDF 5 bound to BMPR IB and BMPR 2 but not to BMPR IA in ROB C 26 cells and other nontransfected cell lines . ^^^ Moreover , a transcriptional activation signal was efficiently transduced by BMPR IB in the presence of BMPR 2 or ActR 2 after stimulation by GDF 5 . ^^^ These results suggest that BMPR IB mediates certain signals for GDF 5 after forming the heteromeric complex with BMPR 2 or ActR II . . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| The recently cloned bone morphogenetic factor receptor type 2 ( BMPR 2 ) was compared with the ActR 2 and several type 1 receptors including ActR 1 , ActR IB , BMPR IA , BMPR IB and TbetaR 1 . ^^^ At E 15 , the expression of ActR 2 mRNA was stronger than that of BMPR 2 in the spinal cord , followed in intensity by the expression of ActR 1 , ActR IB , BMPR IA , BMPR IB and TbetaR 1 mRNA . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| The expression patterns of the type 2 BMP receptor ( BMPR 2 ) and three type 1 BMP receptors ( ActR 1 , BMPR IA and BMPR IB ) were examined in preimplantation embryos by means of heminested reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ BMPR 2 , BMPR IA and BMPR IB mRNAs were also detected in undifferentiated and differentiated embryonal carcinoma and embryonic stem cells . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| We have reported previously that BMPR IB mRNA expression is highest in the prostate , a characteristic that is not shared by the other BMPRs , BMPR IA and BMPR 2 . ^^^ Semiquantitative RT PCR showed that BMPR IB mRNA was induced by androgen in the androgen sensitive human prostatic cancer cell line LNCaP , whereas the expression of BMPR IA and BMPR 2 mRNAs was not affected by androgen . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Receptor binding studies of CDMP 1 and CDMP 2 revealed that both have affinity for the BMP receptor type IB ( BMPR IB ) and BMPR 2 , and weakly for BMPR IA . ^^^ Moreover , using a promoter / reporter construct , transcriptional activation signal was transduced by BMPR IB in the presence of BMPR 2 upon CDMP 1 and CDMP 2 binding . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| In this study , in situ hybridization analyses demonstrate that BMP specific type 1 ( BMPR IA and BMPR IB ) and type 2 ( BMPR 2 ) receptor mRNAs are expressed at significant levels in multiple regions of the CNS , cranial ganglia , and peripheral sensory and autonomic ganglia during the embryonic and neonatal periods . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis demonstrated that cells expressing either BMP 2 / 4 or their receptors ( BMPR IA , BMPR IB , and BMPR 2 ) preferentially appeared in nodules . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| We analyzed poly ( A ) + RNA from rat incisor pulp and bovine adult pulp by reverse transcriptase / polymerase chain reaction ( RT PCR ) , using a degenerate primers corresponding to the most conserved amino acid sequences in the intracellular serine / threonine kinase of type 1 or type 2 like kinase 1 ( ALK 1 ) , ALK 2 , ALK 3 ( bone morphogenetic protein receptor type IA , BMPR IA ) , ALK 4 ( B 1 ) , ALK 5 , ALK 6 ( BMPR IB ) , and BMPR 2 ( BMP type 2 receptor ) was found to be in dental pulp . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| C2C12 cells expressed BMPR IA and BMPR 2 mRNAs , but not BMPR IB mRNA at detectable levels in Northern blotting . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| In reference to our previous study of BMP type 1 receptors ( BMPR IA and BMPR IB ) , BMPR 2 was found to be co localized with BMPR IA and BMPR IB . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| In this study , we studied immunohistochemically the spatial and temporal localization of BMP 2 / 4 , osteogenic protein 1 ( OP 1 , or BMP 7 ) , and BMP receptors ( BMPR IA , BMPR IB , and BMPR 2 ) in the epiphyseal plate of growing rats . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Smad 1 , Smad 5 , and Smad 8 , but not Smad 2 and Smad 3 , were found to stably interact with the kinase deficient BMPR IB after it was phosphorylated by the BMPR 2 kinase . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| METHODS : Transcription of bone morphogenetic proteins ( BMP ) 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 ; growth differentiation factor ( GDF ) 5 ) , and BMP receptors ( BMPR ) types 1 ( BMPR IA , BMPR IB ) and 2 ( BMPR 2 ) was investigated by reverse transcription polymerase chain reaction ( RT PCR ) in ex vivo and cultured cells . ^^^ RESULTS : Transcription of BMP 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 and receptors of BMPR IA , BMPR IB and BMPR 2 was detected in ex vivo and cultured epithelium and stroma . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMP signaling occurs via hetero oligomeric serine / threonine kinase complexes of BMP type 1 ( BMPR IA or BMPR IB ) and type 2 receptors ( BMPR 2 ) . ^^^ Using somatic cell hybrid and FISH analyses , the BMPR1A , BMPR1B , and BMPR 2 genes were assigned to 10q23 , 4q22 24 , and 2q33 34 , respectively . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| In contrast , binding of BMP 6 to BMPR IB ( ALK 6 ) , and less efficiently to ALK 2 and BMPR IA , together with BMPR 2 was detected in ROB C 26 cells . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Among prostate cancer specimens , well differentiated cancers were positive for the expression of BMPR 2 , BMPR IA , and BMPR IB , for the most part . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) analyses indicate that both upper and lower chondrocytes produce messenger RNA ( mRNA ) for all three receptors : BMPR type IA ( BMPR IA ) , BMPR type IB ( BMPR IB ) , and BMPR type 2 ( BMPR 2 ) . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction of PASMC mRNA detected transcripts for type 1 ( TGF betaRI , Alk 1 , ActRI , and BMPRIB ) and type 2 ( TGF betaRII , BMPR 2 , ActRII , ActRIIB ) receptors . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| In the present study , in situ hybridisation histochemistry was used to localise mRNAs for BMP type 1 receptors ( BMPR IA and BMPR IB ) and the BMP type 2 receptor ( BMPR 2 ) in developing mouse metanephroi . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Messenger RNAs for BMP 2 , 4 , 7 , the BMP type 1 receptors Act R 1 ( alk 2 , activin like kinase receptor ) , BMPR IA ( alk 3 ) , IB ( alk 6 ) , and the type 2 receptor BMPR 2 were detected . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| The sections were rehydrated , submitted to microwave antigen retrieval and treated with polyclonal antibodies against BMPR1A , BMPR1B and BMPR 2 . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| With use of immunohistochemical analysis , we studied the localization of BMP 2 , BMP 4 , and BMP 7 and their receptors BMPR IA , BMPR IB , and BMPR 2 as well as pSmad 1 . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| In the present study , mRNAs for three BMP subtype 1 receptors ( ActR 1 , BMPR IA , and BMPR IB ) and one BMPR 2 receptor were detected by Northern analysis in two human osteosarcoma cell lines ( SaOS 2 and TE 85 ) and in the primary cultures of fetal rat calvaria ( FRC ) cells . ^^^ The present results suggest that the ActR 1 , BMPR IA , and BMPR IB receptors and the BMPR 2 receptor are expressed and functional for OP 1 in FRC cells and that regulation of synthesis of these receptors may be a mechanism by which a specific cell type responds to OP 1 . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| In transfection experiments with HEK 293 cells , co expression of FecB ( + ) BMPR1B and BMPR 2 resulted in a 2 . 6 fold ( P < 0 . 01 ) induction of the activity of a BMP specific luciferase reporter construct by BMP 4 . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMPR IB mRNA was similar in G of all follicles , and BMPR 2 mRNA increased with development . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| In control cultures , the steady state mRNA levels of ActR 1 , BMPR IA , BMPR IB , and BMPR 2 increased as a function of time in culture . ^^^ OP 1 treatment stimulated mRNA expression of BMPR IA and BMPR 2 , but had little effect on ActR 1 and BMPR IB mRNA expression . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Disc cells expressed the receptors BMPR1A , BMPR1B , and BMPR 2 , which are relevant for GDF 5 action . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| RESULTS : BMP receptors ( BMPR ) Ia , BMPR Ib , and BMPR 2 are all expressed in colonic epithelial cell lines . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| The prevalence of MADH 4 and BMPR1A mutations in juvenile polyposis and absence of BMPR 2 , BMPR1B , and ACVR 1 mutations . ^^^ A total of 77 JP cases were sequenced for mutations in the MADH 4 , BMPR1A , BMPR1B , BMPR 2 , and / or ACVR 1 ( activin A receptor ) genes . ^^^ No mutations were found in BMPR1B , BMPR 2 , or ACVR 1 in 32 MADH 4 and BMPR1A mutation negative cases . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| METHODS : Dupuytren ' s fibroblasts and normal palmar fascia fibroblasts ( control ) were analyzed for messenger RNA expression of BMPs ( BMP 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 and 11 ) , their receptors ( BMPR IA , BMPR IB , and BMPR 2 ) , and their antagonists ( follistatin and noggin ) by reverse transcription polymerase chain reaction ( PCR ) . ^^^ RESULTS : With reverse transcription PCR the expression profile for normal palmar fascia fibroblasts versus Dupuytren ' s fibroblasts was found to show similar expression of BMP 1 and 11 ; qualitatively decreased expression of BMP 6 , BMP 8 , BMPR IA , BMPR IB , and BMPR 2 in Dupuytren ' s fibroblasts ; and no expression of BMP 4 in Dupuytren ' s fibroblasts . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| We studied the presence and distribution of growth differentiation factor 9 ( GDF 9 ) , bone morphogenetic protein 15 ( BMP 15 ) , and BMP receptors types 2 ( BMPR 2 ) , 1A ( BMPR1A ) , and 1B ( BMPR1B ) in goat ovaries to find evidence for their possible roles in folliculogenesis . ^^^ The mRNAs for GDF 9 , BMP 15 , BMPR 2 , BMPR1A , and BMPR1B were detected in primordial , primary , and secondary follicles as well as in oocyte and granulosa cells of antral follicles . ^^^ Transcripts for BMPR 2 , BMPR1A , BMPR1B , and GDF 9 , and GDF 9 protein were furthermore found in corpora lutea . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction studies with antral follicles showed the expression of BMPR IA , BMPR IB , ActR IA , ActR IIB , BMPR 2 and BMP 4 mRNA in all follicular compartments , while BMP 2 mRNA was generally restricted to theca and cumulus tissue . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Except at the late phase of treatment , CDMP treatment did not change the expression of ActR IA , BMPR IA , BMPR IB , BMPR 2 , and ALK 7 mRNAs . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| FSH administration upregulated BMP type IA ( BMPR1A ) and IB ( BMPR1B ) receptors , activin type 2 receptor ( ACVR 2 ) , and BMP type 2 receptor ( BMPR 2 ) . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the pattern of expression of BMP receptors , including Bmpr Ia , Bmpr Ib , Bmpr 2 , Actr 1 . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| GDF 5 ( growth and differentiation factor five ) , a member of the TGF beta superfamily , binds specifically to BMPR1b , BMPR 2 and ACTR2a receptors forming a heterodimeric complex , thereby inducing phosphorylation of smad 1 , 5 , 8 and translocation to the nucleus . ^^^ We observed the expression of BMPR1a , BMPR1b , BMPR 2 , ACTR2a , smad 1 , smad 5 , ID 1 , ID 2 and ID 3 in HUVSMC . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| METHODS : Synovial fluids , single cell suspensions of cultured fibroblast like synoviocytes ( FLS ) , and synovial tissues were examined by immunohistology with antibodies to BMPR type IA ( BMPRIA ) , BMPRIB , and BMPRII and then quantified using computerized image analysis . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| All three cell types expressed a range of BMP responsive type 1 ( BMPRIB , ActRI ) and type 2 ( BMPRII , ActRII , ActRIIB ) receptors supporting autocrine / paracrine roles within the follicle . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| In this study we examine the spatio temporal expression patterns of activin receptors ( ActRIIA , ActRIIB , ALK 1 , and ALK 2 ) , BMP receptors ( BMPRII , ALK 3 , and ALK 6 ) , and the distribution of the phosphorylated forms of Smad 1 and Smad 2 during normal lens development ( E 12 P21 ) and aberrant development in transgenic mice that express dominant negative TGFbeta receptors . ^^^ RESULTS : RT PCR of RNA from postnatal lenses showed distinct expression of ActRIIA , ActRIIB , BMPRII , and ALK 3 but not ALK 1 , ALK 2 , or ALK 6 . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Also ALK 6 together with related cell surface receptors such as ALK 5 and BMPRII mRNA are present in oocytes at most , if not all , stages of follicular growth . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Based on the recently discovered role of bone morphogenetic proteins ( BMPs ) in ENS development , we examined the expression of the ligands , BMP 2 and BMP 4 , and their receptors , BMPRIA , BMPRIB , and BMPRII , during formation of the human ENS . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMPRIB was detected in trachea but not in esophagus and BMPRII was detected in esophagus but not in trachea . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| The mRNAs encoding BMP 2 , BMP 4 , BMP 7 and the oocyte derived growth factor , growth differentiation factor ( GDF ) 9 were detected in the pituitaries of cyclic ewes by reverse transcriptase PCR , as well as the mRNAs encoding the BMP type 1 receptors , BMPR IA ( activin receptor like kinase ( ALK ) 3 ) and BMPR IB ( ALK 6 ) , and type 2 receptors ( BMPR 2 ) . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Here , we show the existence of mRNA for BMP 2 and for the BMP receptors BMPR1A , BMPR1B , BMPRII , ACVR1A , ACVR 2 , and ACVR2B in differentiated mouse podocytes and the protein expression of BMPR1A in human glomerular podocytes . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Tissues were analyzed using immunohistochemistry for BMP ligand ( BMP 2 , BMP 4 , BMP 7 ) and receptor ( BMPRIA , BMPRIB , BMPRII ) expression . ^^^ However , in the lung epithelium , only BMPRII was found , whereas BMPRIA and BMPRIB remained absent . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| GDF 9 and BMPs initiate signaling by assembling type 1 ( ALK 3 , ALK 5 and ALK 6 ) and type 2 ( BMPRII ) receptors . ^^^ The aim of the present study was to clarify the involvement of receptor systems for GDF 9 and BMPs in follicular selection by examining the effects of FSH and estradiol 17beta ( E 2 ) on the regulation of BMPRII , ALK 3 , ALK 5 and ALK 6 mRNA expression in bovine granulosa cells ( GCs ) . ^^^ Total RNA was extracted and the mRNA expression of BMPRII , ALK 3 , ALK 5 and ALK 6 was estimated by the quantitative real time PCR method using a LightCycler . ^^^ The expression of BMPRII , ALK 5 , ALK 3 and ALK 6 genes in the TCs was not significantly different between PRFs and POFs . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we demonstrated the roles of BMPRII , ALK 3 and ALK 6 as the receptors for the orphan ligands GDF 6 , GDF 7 and BMP 10 . ^^^ |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13873 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|