Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Ihh has biological properties similar to those of Sonic hedgehog ( Shh ) , including the ability to regulate the conserved targets Patched ( Ptc ) and Gli . ^^^ The direct target of Ihh signaling is the perichondrium , where Gli and Ptc flank the expression domain of Ihh . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
We cloned a mouse ( m ) Smo cDNA and studied the expression patterns of Ihh , Ptc , Smo , and Gli mRNAs in mouse chondrogenic EC cells , ATDC 5 . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
However , gene expression and function of Ihh and its signaling molecules , Ptc and Smo , at the initial stage of fracture repair remain unknown . ^^^ In the present study , we showed by RT PCR of mouse rib fractures that the upregulation of Ihh mRNA occurred within hours after fracture , immediately followed by that of Ptc mRNA , and that both Ihh and Ptc mRNAs exhibited the time course similar to those of OP and OC mRNAs at the initial stage of fracture repair . ^^^ By in situ hybridization analysis , the transcripts of Ptc and Smo genes localized in bone marrow of unfractured ribs , and those of Ihh , Ptc , and Smo were expressed in the vicinity of the fracture site at 8 h after fracture . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Using semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) on growth plate tissue , IHH and components of its receptor complex , patched ( PTC ) and smoothened ( SMO ) , PTHrP and the type 1 PTH / PTHrP receptor messenger RNA ( mRNA ) were shown at all ages studied irrespective of gender . ^^^ Immunohistochemistry confirmed the observations made with in situ hybridization , by showing the presence of IHH , PTC , PTHrP , and PTH / PTHrP receptor protein in prehypertrophic and hypertrophic chondrocytes . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Increased expression of PATCHED : ( PTC : ) was observed , independent of unaltered expression of parathyroid hormone related peptide ( PTHrP ) receptor and Indian Hedgehog ( IHH : ) , suggesting a new regulatory role for Fgfr 3 in embryos . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Here we report that Hhs Ihh and Dhh and their receptors patched ( Ptc ) and smoothened are expressed in the endocrine islets of Langerhans of the fully developed rat pancreas and in the clonal gamma cell line INS 1 . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Parathyroid hormone related peptide ( PTHrP ) , Indian hedgehog ( Ihh ) , and patched ( Ptc ; a receptor for Ihh ) were immunolocalized in tissue undergoing endochondral ossification in the human . ^^^ PTHrP , Ihh , and Ptc were immunolocalized in prehypertrophic and hypertrophic chondrocytes in mature cartilage matrix . ^^^ PTHrP and Ptc were immunostained in proliferating chondrocytes and perichondrial cells , whereas Ihh was not . ^^^ PTHrP , Ihh , and Ptc showed positive immunostaining in osteoblasts in the bone forming area . ^^^ In the bone resorption site , PTHrP was immunolocalized in osteoclasts , whereas Ihh and Ptc were not . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Indian hedgehog ( Ihh ) , patched ( Ptc ) , and Gli 3 are expressed at low levels in the endometrial epithelium on day 1 of pregnancy . ^^^ Lower induction of Ihh , Ptc , and Hoxa 10 is seen in response to progesterone in the uteri of Pgr ( / ) mutant mice lacking progesterone nuclear steroid receptor . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Messenger ( m ) RNA for PTHrP , Ihh , PTH receptor ( PTHR ; a receptor for PTHrP ) , patched ( Ptc ; a receptor for Ihh ) , bone morphogenetic protein ( BMP ) 6 , and collagen type 10 ( COL 10 ; a marker for mature chondrocyte ) was localized in the tissue sections by performing in situ hybridization . ^^^ In the early stage , mRNA for COL 10 , Ihh , and BMP 6 was absent ; however , mRNA for PTHrP , PTHR , and Ptc was detected in the anterior margin of the cervical discs . ^^^ CONCLUSIONS : The localization of PTHrP , Ihh , BMP 6 , and the receptors PTHR and Ptc demonstrated in the present experimental model indicates the possible involvement of molecular signaling by PTHrP ( through the PTHR ) , Ihh ( through the Ptc ) , and BMP 6 in the regulation of chondrocyte maturation leading to endochondral ossification in spondylosis . . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Our results demonstrate that neither Shh nor Ihh is required for mammary gland morphogenesis and functional differentiation , suggesting that the two members of the Hedgehog family may have redundant function in activating the Ptc 1 signaling pathway during mammary gland development . . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Bmp 2 , 4 , Patched ( Ptc ) and Indian Hedgehog ( IHH ) . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Primary osteoblasts and several clonal osteoblast like cell lines express Indian hedgehog ( Ihh ) , and genes encoding both components of its receptor , patched ( Ptc ) and smoothened ( Smo ) . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Indian hedgehog ( IHH ) and its receptors patched ( PTC ) and smoothened ( SMO ) belong to the hedgehog family of signaling molecules , which are essential for a variety of patterning events during mammalian tIssue development . ^^^ Correlation between diabetic and non diabetic CP patients revealed no significant difference in IHH , SMO , or PTC immunoreactivity . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
The changes in growth plate morphology were accompanied by an increase in expression of FGF 2 in proliferating chondrocytes and decreased expression of Indian hedgehog ( Ihh ) , patched ( Ptc ) and parathyroid hormone related protein ( PTHrP ) in prehypertrophic cells . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Indian hedgehog ( Ihh ) and its 2 signaling receptors , patched ( Ptc ) and smoothened ( Smo ) , are involved in pancreatic development and regulation of beta cell function as well as in certain human tumors . ^^^ Quantitative RT PCR and immunohistochemistry were utilized to analyze the expression , localization and transcriptional regulation of Ihh , Ptc and Smo . ^^^ By quantitative RT PCR , Ihh , Ptc and Smo mRNA levels were increased 35 , 1 . 2 and 1 . 6 fold , respectively , in pancreatic cancer tissues in comparison to normal pancreatic tissues . ^^^ By immunohistochemistry , Ihh , Ptc and Smo were expressed in the islet cells of normal and cancerous tissues and in pancreatic cancer cells . ^^^ In conclusion , Ihh and its receptors Ptc and Smo are expressed in pancreatic cancer , and blockage of hedgehog signaling results in inhibition of pancreatic cancer cell growth , suggesting that aberrant activation of the Ihh signaling pathway contributes to tumor development in this malignancy . . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Previously , it has been shown that Indian hedgehog ( Ihh ) and its two signaling receptors patched ( Ptc ) and smoothened ( Smo ) are involved in the pathogenesis of chronic pancreatitis ( CP ) and PDAC . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Importantly , neither Pdgfralpha mRNA patterns nor levels were altered in Ihh mutant embryos although Gli 1 and Ptc mRNA levels were dramatically reduced . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Alcian blue staining for cartilage nodules and real time reverse transcription polymerase chain reaction for the expression of genes encoding type 2 collagen , aggrecan , transforming growth factor ( TGF ) beta 1 , bone morphogenetic protein ( BMP ) 4 , parathyroid hormone related peptide ( PTHrP ) , indian hedgehog ( Ihh ) , and patched ( Ptc ) were performed in ATDC 5 cells cultured with DPH . ^^^ During promoted chondrogenic differentiation , it was observed that DPH increased the mRNA expression of TGF beta 1 , BMP 4 , Ihh , and Ptc , in a dose dependent manner on Days 5 to 15 . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Here we show that Indian hedgehog ( Ihh ) , another hedgehog family member , and Patched 1 ( Ptc 1 ) , a receptor and negative regulator of hedgehog activity , are expressed in pancreatic tissue . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
RA at more than 10 ( 8 ) M induced the expression of Ihh and Patched 1 ( Ptc 1 ) within 3 h , before it increased the type 10 collagen mRNA level at 6 24 h . ^^^ In contrast to RA , PTH ( 1 84 ) at 10 ( 7 ) M abolished the mRNA expression of Ihh and Ptc 1 within 2 4 h , before it suppressed the expression of type 10 collagen at 12 24 h . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
We show that Smo acts epistatic to Ptc 1 to mediate Shh and Ihh signaling in the early mouse embryo . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Interestingly , expression of Ihh , Gli 1 and Ptc 1 peaked during the maturation phase . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
The expression of SHH receptor , Patched 1 ( Ptc 1 ) , was greatly increased in all cartilage , as well as the expression of parathyroid hormone related protein ( PTHrP ) at the articular surface ; while the expression of Indian Hedgehog ( Ihh ) , another member of Hh family that controls the rate of chondrocyte maturation , was greatly reduced and restricted to the displaced chondrocyte columns . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
This study investigated the expression of Ihh , Patched 1 and 2 ( Ptc 1 , Ptc 2 ) , Smoothened ( Smo ) , Gli 1 , and Gli 3 , in naturally acquired articular osteochondrosis , using an equine model . ^^^ Ihh , Ptc 1 , Smo , Gli 1 , and Gli 3 mRNA expression levels were evaluated by real time quantitative PCR . ^^^ Spatial tissue expression was determined by in situ hybridization for Ihh and Smo and immunohistochemistry for Ptc 1 and Ptc 2 . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Indian hedgehog ( Ihh ) , Gli 1 , Gli 3 , Patched 1 ( Ptc 1 ) , Smoothened ( Smo ) , Noggin , bone morphogenetic protein 6 ( BMP 6 ) , BMP 2 , parathyroid hormone related peptide ( PTHrP ) , and PTH / PTHrP receptor mRNA expression levels were evaluated by real time quantitative PCR . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Correspondingly , the expression of certain signaling molecules in cartilage , most notably the Indian hedgehog ( Ihh ) receptor patched ( Ptch ) , was lower in A CREB expressing versus wild type chondrocytes . ^^^ CREB appears to promote Ptch expression in proliferating chondrocytes via an Ihh independent pathway ; phospho CREB levels were comparable in cartilage from Ihh ( / ) and wild type mice . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
We now show that PTCH is up regulated in both human and mouse sebaceous tumors and is accompanied by overexpression of Indian hedgehog ( IHH ) . ^^^ PTCH 1 and IHH are up regulated during human sebocyte differentiation in vitro and inhibition of hedgehog signaling inhibits growth and stimulates differentiation . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Quantitative real time PCR for IHH , PTCH , SMO , and GLI 2 was performed on a subset of tumours . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Normally , these cells surrounding the chondrogenic condensation are exposed to IHH , as evidenced by their expression of the hedgehog target genes , patched ( Ptch ) and Gli 1 . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Furthermore the expression of the Ihh target genes patched ( Ptch ) and PTHrP is reactivated in Ihh / ; Gli 3 / mutants . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
We describe a gradual decrease in the expression of Patched ( PTCH ) and glioma associated oncogene homologue 1 ( GLI 1 ) ( both transcribed upon IHH activity ) , and GLI 2 with increasing malignancy , suggesting that IHH signalling is inactive and PTHLH signalling is IHH independent in secondary peripheral chondrosarcomas . cDNA expression profiling and immunohistochemical studies suggest that transforming growth factor beta ( TGF beta ) mediated proliferative signalling is active in high grade chondrosarcomas since TGF beta downstream targets were upregulated in these tumours . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
A total of 106 uterine cervical cancers and related lesions ( 37 squamous cell carcinomas , 23 cervical intraepithelial neoplasia ( CIN ) 3 , 10 CIN 2 , four CIN 1 , 32 normal cervical epithelia ) were immunohistochemically analyzed with anti Shh , Indian Hh ( Ihh ) , Patched ( PTCH ) , Smoothened ( Smo ) , Gli 1 , Gli 2 , Gli 3 antibodies on paraffin blocks . ^^^ In case of Ihh , PTCH , Smo and Gli 1 , their expression in normal epithelium was completely absent or rare . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
IHH , SHH , Patched ( PTCH ) , Smoothened ( SMO ) , and downstream targets were expressed more frequently and highly in the diffuse as compared with intestinal type cancers . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Through genetic combinations with null alleles of patched 1 ( Ptch 1 ) , sonic hedgehog ( Shh ) and Indian hedgehog ( Ihh ) , we demonstrate that Disp 1 genetically interacts with Hh signaling components . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Signals of Hedgehog family proteins ( SHH , IHH and DHH ) are transduced through Patched family receptors ( PTCH 1 and PTCH 2 ) and Smoothened ( SMO ) to GLI family transcription factors ( GLI 1 , GLI 2 and GLI 3 ) . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Sonic hedgehog ( SHH ) , Desert hedgehog ( DHH ) and Indian hedgehog ( IHH ) bind to Patched family receptors ( PTCH 1 and PTCH 2 ) to transduce signals to GLI 1 , GLI 2 and GLI 3 . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
Human SHH , IHH , DHH ( Hedgehog homologs ) , HHAT ( Hedgehog acyltransferase ) , HHIP ( Hedgehog interacting protein ) , DISP 1 , DISP 2 , DISP 3 ( Dispatched homologs ) , PTCH 1 , PTCH 2 ( Patched homologs ) , SMO ( Smoothened homolog ) , KIF 27 , KIF 7 ( Costal 2 homologs ) , STK 36 ( Fused homolog ) , SUFU ( SuFu homolog ) , DZIP 1 ( Iguana homolog ) , GLI 1 , GLI 2 and GLI 3 ( Cubitus interruptus homologs ) are implicated in the Hedgehog signaling . ^^^ SHH up regulation , IHH upregulation and HHIP down regulation lead to aberrant activation of Hedgehog signaling through PTCH 1 to GLI 1 in gastric cancer . ^^^
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
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Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13635 and Q14623	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Ihh has biological properties similar to those of Sonic hedgehog ( Shh ) , including the ability to regulate the conserved targets Patched ( Ptc ) and Gli . ^^^ The direct target of Ihh signaling is the perichondrium , where Gli and Ptc flank the expression domain of Ihh . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
We cloned a mouse ( m ) Smo cDNA and studied the expression patterns of Ihh , Ptc , Smo , and Gli mRNAs in mouse chondrogenic EC cells , ATDC 5 . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
However , gene expression and function of Ihh and its signaling molecules , Ptc and Smo , at the initial stage of fracture repair remain unknown . ^^^ In the present study , we showed by RT PCR of mouse rib fractures that the upregulation of Ihh mRNA occurred within hours after fracture , immediately followed by that of Ptc mRNA , and that both Ihh and Ptc mRNAs exhibited the time course similar to those of OP and OC mRNAs at the initial stage of fracture repair . ^^^ By in situ hybridization analysis , the transcripts of Ptc and Smo genes localized in bone marrow of unfractured ribs , and those of Ihh , Ptc , and Smo were expressed in the vicinity of the fracture site at 8 h after fracture . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Using semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) on growth plate tissue , IHH and components of its receptor complex , patched ( PTC ) and smoothened ( SMO ) , PTHrP and the type 1 PTH / PTHrP receptor messenger RNA ( mRNA ) were shown at all ages studied irrespective of gender . ^^^ Immunohistochemistry confirmed the observations made with in situ hybridization , by showing the presence of IHH , PTC , PTHrP , and PTH / PTHrP receptor protein in prehypertrophic and hypertrophic chondrocytes . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Increased expression of PATCHED : ( PTC : ) was observed , independent of unaltered expression of parathyroid hormone related peptide ( PTHrP ) receptor and Indian Hedgehog ( IHH : ) , suggesting a new regulatory role for Fgfr 3 in embryos . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Here we show that Indian hedgehog ( Ihh ) , another hedgehog family member , and Patched 1 ( Ptc 1 ) , a receptor and negative regulator of hedgehog activity , are expressed in pancreatic tissue . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Here we report that Hhs Ihh and Dhh and their receptors patched ( Ptc ) and smoothened are expressed in the endocrine islets of Langerhans of the fully developed rat pancreas and in the clonal gamma cell line INS 1 . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Correspondingly , the expression of certain signaling molecules in cartilage , most notably the Indian hedgehog ( Ihh ) receptor patched ( Ptch ) , was lower in A CREB expressing versus wild type chondrocytes . ^^^ CREB appears to promote Ptch expression in proliferating chondrocytes via an Ihh independent pathway ; phospho CREB levels were comparable in cartilage from Ihh ( / ) and wild type mice . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
RA at more than 10 ( 8 ) M induced the expression of Ihh and Patched 1 ( Ptc 1 ) within 3 h , before it increased the type 10 collagen mRNA level at 6 24 h . ^^^ In contrast to RA , PTH ( 1 84 ) at 10 ( 7 ) M abolished the mRNA expression of Ihh and Ptc 1 within 2 4 h , before it suppressed the expression of type 10 collagen at 12 24 h . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
We show that Smo acts epistatic to Ptc 1 to mediate Shh and Ihh signaling in the early mouse embryo . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Indian hedgehog ( Ihh ) , patched ( Ptc ) , and Gli 3 are expressed at low levels in the endometrial epithelium on day 1 of pregnancy . ^^^ Lower induction of Ihh , Ptc , and Hoxa 10 is seen in response to progesterone in the uteri of Pgr ( / ) mutant mice lacking progesterone nuclear steroid receptor . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Messenger ( m ) RNA for PTHrP , Ihh , PTH receptor ( PTHR ; a receptor for PTHrP ) , patched ( Ptc ; a receptor for Ihh ) , bone morphogenetic protein ( BMP ) 6 , and collagen type 10 ( COL 10 ; a marker for mature chondrocyte ) was localized in the tissue sections by performing in situ hybridization . ^^^ In the early stage , mRNA for COL 10 , Ihh , and BMP 6 was absent ; however , mRNA for PTHrP , PTHR , and Ptc was detected in the anterior margin of the cervical discs . ^^^ CONCLUSIONS : The localization of PTHrP , Ihh , BMP 6 , and the receptors PTHR and Ptc demonstrated in the present experimental model indicates the possible involvement of molecular signaling by PTHrP ( through the PTHR ) , Ihh ( through the Ptc ) , and BMP 6 in the regulation of chondrocyte maturation leading to endochondral ossification in spondylosis . . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Our results demonstrate that neither Shh nor Ihh is required for mammary gland morphogenesis and functional differentiation , suggesting that the two members of the Hedgehog family may have redundant function in activating the Ptc 1 signaling pathway during mammary gland development . . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Bmp 2 , 4 , Patched ( Ptc ) and Indian Hedgehog ( IHH ) . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Primary osteoblasts and several clonal osteoblast like cell lines express Indian hedgehog ( Ihh ) , and genes encoding both components of its receptor , patched ( Ptc ) and smoothened ( Smo ) . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
We now show that PTCH is up regulated in both human and mouse sebaceous tumors and is accompanied by overexpression of Indian hedgehog ( IHH ) . ^^^ PTCH 1 and IHH are up regulated during human sebocyte differentiation in vitro and inhibition of hedgehog signaling inhibits growth and stimulates differentiation . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Parathyroid hormone related peptide ( PTHrP ) , Indian hedgehog ( Ihh ) , and patched ( Ptc ; a receptor for Ihh ) were immunolocalized in tissue undergoing endochondral ossification in the human . ^^^ PTHrP , Ihh , and Ptc were immunolocalized in prehypertrophic and hypertrophic chondrocytes in mature cartilage matrix . ^^^ PTHrP and Ptc were immunostained in proliferating chondrocytes and perichondrial cells , whereas Ihh was not . ^^^ PTHrP , Ihh , and Ptc showed positive immunostaining in osteoblasts in the bone forming area . ^^^ In the bone resorption site , PTHrP was immunolocalized in osteoclasts , whereas Ihh and Ptc were not . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Through genetic combinations with null alleles of patched 1 ( Ptch 1 ) , sonic hedgehog ( Shh ) and Indian hedgehog ( Ihh ) , we demonstrate that Disp 1 genetically interacts with Hh signaling components . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
The expression of SHH receptor , Patched 1 ( Ptc 1 ) , was greatly increased in all cartilage , as well as the expression of parathyroid hormone related protein ( PTHrP ) at the articular surface ; while the expression of Indian Hedgehog ( Ihh ) , another member of Hh family that controls the rate of chondrocyte maturation , was greatly reduced and restricted to the displaced chondrocyte columns . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Signals of Hedgehog family proteins ( SHH , IHH and DHH ) are transduced through Patched family receptors ( PTCH 1 and PTCH 2 ) and Smoothened ( SMO ) to GLI family transcription factors ( GLI 1 , GLI 2 and GLI 3 ) . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Sonic hedgehog ( SHH ) , Desert hedgehog ( DHH ) and Indian hedgehog ( IHH ) bind to Patched family receptors ( PTCH 1 and PTCH 2 ) to transduce signals to GLI 1 , GLI 2 and GLI 3 . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Quantitative real time PCR for IHH , PTCH , SMO , and GLI 2 was performed on a subset of tumours . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Indian hedgehog ( IHH ) and its receptors patched ( PTC ) and smoothened ( SMO ) belong to the hedgehog family of signaling molecules , which are essential for a variety of patterning events during mammalian tIssue development . ^^^ Correlation between diabetic and non diabetic CP patients revealed no significant difference in IHH , SMO , or PTC immunoreactivity . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Interestingly , expression of Ihh , Gli 1 and Ptc 1 peaked during the maturation phase . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
The changes in growth plate morphology were accompanied by an increase in expression of FGF 2 in proliferating chondrocytes and decreased expression of Indian hedgehog ( Ihh ) , patched ( Ptc ) and parathyroid hormone related protein ( PTHrP ) in prehypertrophic cells . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Indian hedgehog ( Ihh ) and its 2 signaling receptors , patched ( Ptc ) and smoothened ( Smo ) , are involved in pancreatic development and regulation of beta cell function as well as in certain human tumors . ^^^ Quantitative RT PCR and immunohistochemistry were utilized to analyze the expression , localization and transcriptional regulation of Ihh , Ptc and Smo . ^^^ By quantitative RT PCR , Ihh , Ptc and Smo mRNA levels were increased 35 , 1 . 2 and 1 . 6 fold , respectively , in pancreatic cancer tissues in comparison to normal pancreatic tissues . ^^^ By immunohistochemistry , Ihh , Ptc and Smo were expressed in the islet cells of normal and cancerous tissues and in pancreatic cancer cells . ^^^ In conclusion , Ihh and its receptors Ptc and Smo are expressed in pancreatic cancer , and blockage of hedgehog signaling results in inhibition of pancreatic cancer cell growth , suggesting that aberrant activation of the Ihh signaling pathway contributes to tumor development in this malignancy . . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Importantly , neither Pdgfralpha mRNA patterns nor levels were altered in Ihh mutant embryos although Gli 1 and Ptc mRNA levels were dramatically reduced . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
This study investigated the expression of Ihh , Patched 1 and 2 ( Ptc 1 , Ptc 2 ) , Smoothened ( Smo ) , Gli 1 , and Gli 3 , in naturally acquired articular osteochondrosis , using an equine model . ^^^ Ihh , Ptc 1 , Smo , Gli 1 , and Gli 3 mRNA expression levels were evaluated by real time quantitative PCR . ^^^ Spatial tissue expression was determined by in situ hybridization for Ihh and Smo and immunohistochemistry for Ptc 1 and Ptc 2 . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Alcian blue staining for cartilage nodules and real time reverse transcription polymerase chain reaction for the expression of genes encoding type 2 collagen , aggrecan , transforming growth factor ( TGF ) beta 1 , bone morphogenetic protein ( BMP ) 4 , parathyroid hormone related peptide ( PTHrP ) , indian hedgehog ( Ihh ) , and patched ( Ptc ) were performed in ATDC 5 cells cultured with DPH . ^^^ During promoted chondrogenic differentiation , it was observed that DPH increased the mRNA expression of TGF beta 1 , BMP 4 , Ihh , and Ptc , in a dose dependent manner on Days 5 to 15 . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Human SHH , IHH , DHH ( Hedgehog homologs ) , HHAT ( Hedgehog acyltransferase ) , HHIP ( Hedgehog interacting protein ) , DISP 1 , DISP 2 , DISP 3 ( Dispatched homologs ) , PTCH 1 , PTCH 2 ( Patched homologs ) , SMO ( Smoothened homolog ) , KIF 27 , KIF 7 ( Costal 2 homologs ) , STK 36 ( Fused homolog ) , SUFU ( SuFu homolog ) , DZIP 1 ( Iguana homolog ) , GLI 1 , GLI 2 and GLI 3 ( Cubitus interruptus homologs ) are implicated in the Hedgehog signaling . ^^^ SHH up regulation , IHH upregulation and HHIP down regulation lead to aberrant activation of Hedgehog signaling through PTCH 1 to GLI 1 in gastric cancer . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Furthermore the expression of the Ihh target genes patched ( Ptch ) and PTHrP is reactivated in Ihh / ; Gli 3 / mutants . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Normally , these cells surrounding the chondrogenic condensation are exposed to IHH , as evidenced by their expression of the hedgehog target genes , patched ( Ptch ) and Gli 1 . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Previously , it has been shown that Indian hedgehog ( Ihh ) and its two signaling receptors patched ( Ptc ) and smoothened ( Smo ) are involved in the pathogenesis of chronic pancreatitis ( CP ) and PDAC . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
We describe a gradual decrease in the expression of Patched ( PTCH ) and glioma associated oncogene homologue 1 ( GLI 1 ) ( both transcribed upon IHH activity ) , and GLI 2 with increasing malignancy , suggesting that IHH signalling is inactive and PTHLH signalling is IHH independent in secondary peripheral chondrosarcomas . cDNA expression profiling and immunohistochemical studies suggest that transforming growth factor beta ( TGF beta ) mediated proliferative signalling is active in high grade chondrosarcomas since TGF beta downstream targets were upregulated in these tumours . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
A total of 106 uterine cervical cancers and related lesions ( 37 squamous cell carcinomas , 23 cervical intraepithelial neoplasia ( CIN ) 3 , 10 CIN 2 , four CIN 1 , 32 normal cervical epithelia ) were immunohistochemically analyzed with anti Shh , Indian Hh ( Ihh ) , Patched ( PTCH ) , Smoothened ( Smo ) , Gli 1 , Gli 2 , Gli 3 antibodies on paraffin blocks . ^^^ In case of Ihh , PTCH , Smo and Gli 1 , their expression in normal epithelium was completely absent or rare . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
Indian hedgehog ( Ihh ) , Gli 1 , Gli 3 , Patched 1 ( Ptc 1 ) , Smoothened ( Smo ) , Noggin , bone morphogenetic protein 6 ( BMP 6 ) , BMP 2 , parathyroid hormone related peptide ( PTHrP ) , and PTH / PTHrP receptor mRNA expression levels were evaluated by real time quantitative PCR . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
IHH , SHH , Patched ( PTCH ) , Smoothened ( SMO ) , and downstream targets were expressed more frequently and highly in the diffuse as compared with intestinal type cancers . ^^^
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
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Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
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Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
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Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
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Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
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Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
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Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
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Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q14623 and Q13635	Pubmed	SVM Score :0.0
NA