| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| Based on the sex specific expression patterns of Desert Hedgehog ( Dhh ) and its receptor Patched 1 ( Ptch 1 ) in XY gonads , we investigated the potential role of DHH / PTCH1 signaling in the origin and specification of fetal Leydig cells . ^^^ Instead , our results suggest that DHH / PTCH1 signaling triggers Leydig cell differentiation by up regulating Steroidogenic Factor 1 and P 450 Side Chain Cleavage enzyme expression in Ptch 1 expressing precursor cells located outside testis cords . . ^^^ |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| Signals of Hedgehog family proteins ( SHH , IHH and DHH ) are transduced through Patched family receptors ( PTCH 1 and PTCH 2 ) and Smoothened ( SMO ) to GLI family transcription factors ( GLI 1 , GLI 2 and GLI 3 ) . ^^^ |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| Sonic hedgehog ( SHH ) , Desert hedgehog ( DHH ) and Indian hedgehog ( IHH ) bind to Patched family receptors ( PTCH 1 and PTCH 2 ) to transduce signals to GLI 1 , GLI 2 and GLI 3 . ^^^ |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| Human SHH , IHH , DHH ( Hedgehog homologs ) , HHAT ( Hedgehog acyltransferase ) , HHIP ( Hedgehog interacting protein ) , DISP 1 , DISP 2 , DISP 3 ( Dispatched homologs ) , PTCH 1 , PTCH 2 ( Patched homologs ) , SMO ( Smoothened homolog ) , KIF 27 , KIF 7 ( Costal 2 homologs ) , STK 36 ( Fused homolog ) , SUFU ( SuFu homolog ) , DZIP 1 ( Iguana homolog ) , GLI 1 , GLI 2 and GLI 3 ( Cubitus interruptus homologs ) are implicated in the Hedgehog signaling . ^^^ |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| The Dhh receptor patched ( ptc ) 2 was detected in adult sciatic nerves using RT PCR , however , ptc 1 was undetectable under the same experimental condition . ^^^ Both dhh and ptc 2 mRNA levels were down regulated during the degenerative phase postinjury in WT mice , while levels rose again during the phase of nerve regeneration . ^^^ These results suggest that the Dhh Ptc 2 signaling pathway may be involved in the maintenance of adult nerves and may be one of the factors that directly or indirectly determines the response of peripheral nerves to injury . . ^^^ |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| Because Desert Hedgehog ( Dhh ) is expressed specifically in the testis and is required for germ cell development , it is likely that PTCH 2 mediates its activity in vivo . ^^^ Chromosomal localization of PTCH 2 places it on chromosome 1p33 34 , a region deleted in some germ cell tumors , raising the possibility that PTCH 2 may be a tumor suppressor in Dhh target cells . . ^^^ |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| We show that Schwann cell derived Desert hedgehog ( Dhh ) signals the formation of the connective tissue sheath around peripheral nerves . mRNAs for dhh and its receptor patched ( ptc ) are expressed in Schwann cells and perineural mesenchyme , respectively . ^^^ In nerve fibroblasts , Dhh upregulates ptc and hedgehog interacting protein ( hip ) . ^^^ |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| Here we report that Hhs Ihh and Dhh and their receptors patched ( Ptc ) and smoothened are expressed in the endocrine islets of Langerhans of the fully developed rat pancreas and in the clonal gamma cell line INS 1 . ^^^ |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43323 and Q13635 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| We show that Schwann cell derived Desert hedgehog ( Dhh ) signals the formation of the connective tissue sheath around peripheral nerves . mRNAs for dhh and its receptor patched ( ptc ) are expressed in Schwann cells and perineural mesenchyme , respectively . ^^^ In nerve fibroblasts , Dhh upregulates ptc and hedgehog interacting protein ( hip ) . ^^^ |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| Here we report that Hhs Ihh and Dhh and their receptors patched ( Ptc ) and smoothened are expressed in the endocrine islets of Langerhans of the fully developed rat pancreas and in the clonal gamma cell line INS 1 . ^^^ |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| The Dhh receptor patched ( ptc ) 2 was detected in adult sciatic nerves using RT PCR , however , ptc 1 was undetectable under the same experimental condition . ^^^ Both dhh and ptc 2 mRNA levels were down regulated during the degenerative phase postinjury in WT mice , while levels rose again during the phase of nerve regeneration . ^^^ These results suggest that the Dhh Ptc 2 signaling pathway may be involved in the maintenance of adult nerves and may be one of the factors that directly or indirectly determines the response of peripheral nerves to injury . . ^^^ |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| Because Desert Hedgehog ( Dhh ) is expressed specifically in the testis and is required for germ cell development , it is likely that PTCH 2 mediates its activity in vivo . ^^^ Chromosomal localization of PTCH 2 places it on chromosome 1p33 34 , a region deleted in some germ cell tumors , raising the possibility that PTCH 2 may be a tumor suppressor in Dhh target cells . . ^^^ |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| Based on the sex specific expression patterns of Desert Hedgehog ( Dhh ) and its receptor Patched 1 ( Ptch 1 ) in XY gonads , we investigated the potential role of DHH / PTCH1 signaling in the origin and specification of fetal Leydig cells . ^^^ Instead , our results suggest that DHH / PTCH1 signaling triggers Leydig cell differentiation by up regulating Steroidogenic Factor 1 and P 450 Side Chain Cleavage enzyme expression in Ptch 1 expressing precursor cells located outside testis cords . . ^^^ |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| Signals of Hedgehog family proteins ( SHH , IHH and DHH ) are transduced through Patched family receptors ( PTCH 1 and PTCH 2 ) and Smoothened ( SMO ) to GLI family transcription factors ( GLI 1 , GLI 2 and GLI 3 ) . ^^^ |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| Sonic hedgehog ( SHH ) , Desert hedgehog ( DHH ) and Indian hedgehog ( IHH ) bind to Patched family receptors ( PTCH 1 and PTCH 2 ) to transduce signals to GLI 1 , GLI 2 and GLI 3 . ^^^ |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| Human SHH , IHH , DHH ( Hedgehog homologs ) , HHAT ( Hedgehog acyltransferase ) , HHIP ( Hedgehog interacting protein ) , DISP 1 , DISP 2 , DISP 3 ( Dispatched homologs ) , PTCH 1 , PTCH 2 ( Patched homologs ) , SMO ( Smoothened homolog ) , KIF 27 , KIF 7 ( Costal 2 homologs ) , STK 36 ( Fused homolog ) , SUFU ( SuFu homolog ) , DZIP 1 ( Iguana homolog ) , GLI 1 , GLI 2 and GLI 3 ( Cubitus interruptus homologs ) are implicated in the Hedgehog signaling . ^^^ |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13635 and O43323 |
Pubmed |
SVM Score :0.0 |
| NA |
|