| Interacting proteins: Q13618 and Q15843 |
Pubmed |
SVM Score :0.0 |
| Here we report that all Hs Cul family proteins , such as Cul 1 , Cul 2 , Cul 3 , Cul 4B , and Cul 5 , in addition to Cul 4A , were modified by covalent attachment of NEDD 8 in rabbit reticulocyte lysates . ^^^ The expressions of Cul 1 , Cul 2 , and Cul 3 resembled each other and were apparently correlated to those of NEDD 8 and the NEDD 8 ligating system in various human cells and tissues . ^^^ |
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| Interacting proteins: Q13618 and Q15843 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Here , we identified and characterized the COP9 / signalosome in C . elegans and showed that it promotes deneddylation of CUL 3 , a critical target of the Nedd 8 conjugation pathway . ^^^ |
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| Interacting proteins: Q13618 and Q15843 |
Pubmed |
SVM Score :0.0 |
| Consistent with this notion , Cul 3 is inactivated by a mutation in its conserved neddylation site , and Nedd 8 mutant neurons exhibit similar neuronal morphogenetic defects . ^^^ |
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| Interacting proteins: Q13618 and Q15843 |
Pubmed |
SVM Score :0.0 |
| We further show that neddylated Cul 1 and Cul 3 are unstable as suggested by the evidence that Nedd 8 promotes the instability of both cullins and that the unneddylatable forms of cullins are stable . ^^^ |
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| Interacting proteins: Q13618 and Q15843 |
Pubmed |
SVM Score :0.0 |
| NA |
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