| Interacting proteins: Q8TBC4 and Q13564 |
Pubmed |
SVM Score :1.0489531 |
| We show here that , in vivo in mammalian cells , APP BP 1 interacts with hUba 3 , its presumptive partner in the NEDD 8 activation pathway , and that the APP BP 1 binding site for hUba 3 is within amino acids 443 479 . 1.0489531^^^ |
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| Interacting proteins: Q8TBC4 and Q13564 |
Pubmed |
SVM Score :0.0 |
| NEDD 8 was activated by an E 1 ( Ub activating enzyme ) like complex , consisting of APP BP 1 and hUba 3 with high respective homologies to the amino and carboxy terminal regions of E 1 and then linked to hUbc 12 ( a human homolog of yeast Ub conjugating enzyme Ubc12p ) . ^^^ |
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| Interacting proteins: Q8TBC4 and Q13564 |
Pubmed |
SVM Score :0.0 |
| Moreover , human UBA 3 could form a beta mercaptoethanol sensitive conjugate with NEDD 8 in the presence of APP BP 1 , a protein with sequence homology to the N terminal half of ubiquitin activating enzyme . ^^^ |
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| Interacting proteins: Q8TBC4 and Q13564 |
Pubmed |
SVM Score :0.0 |
| Not surprisingly , mutations in APPBP 1 and UBA 3 lead to defects in many cellular functions . ^^^ |
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| Interacting proteins: Q8TBC4 and Q13564 |
Pubmed |
SVM Score :0.0 |
| The E 1 for Nedd 8 is a heterodimer of APP BP 1 and Uba 3 , while the E 2 is Ubc 12 . ^^^ |
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