| Interacting proteins: Q13564 and P61081 |
Pubmed |
SVM Score :0.0 |
| The E 1 for Nedd 8 is a heterodimer of APP BP 1 and Uba 3 , while the E 2 is Ubc 12 . ^^^ |
|
| Interacting proteins: Q13564 and P61081 |
Pubmed |
SVM Score :0.0 |
| The APPBP 1 UBA3 complex initiates NEDD 8 conjugation by first catalyzing adenylation of the C terminus of NEDD 8 and ultimately catalyzing transfer of NEDD 8 to the downstream enzyme in the pathway , Ubc 12 . ^^^ |
|
| Interacting proteins: Q13564 and P61081 |
Pubmed |
SVM Score :0.0 |
| NEDD 8 was activated by an E 1 ( Ub activating enzyme ) like complex , consisting of APP BP 1 and hUba 3 with high respective homologies to the amino and carboxy terminal regions of E 1 and then linked to hUbc 12 ( a human homolog of yeast Ub conjugating enzyme Ubc12p ) . ^^^ |
|
| Interacting proteins: Q13564 and P61081 |
Pubmed |
SVM Score :0.0 |
| We show that expression of APP BP 1 in ts 41 cells drives the cell cycle through the S M checkpoint and that this function requires both hUba 3 and hUbc 12 . ^^^ |
|
| Interacting proteins: Q13564 and P61081 |
Pubmed |
SVM Score :0.0 |
| A dominant negative mutant of the NEDD 8 conjugating enzyme hUbc 12 , which participates in the ubiquitin like pathway initiated by APP BP 1 , blocks neuronal apoptosis caused by APP , APP ( V642I ) , C 31 , or overexpression of APP BP 1 . ^^^ |
|
| Interacting proteins: Q13564 and P61081 |
Pubmed |
SVM Score :0.0 |
| NA |
|