| Interacting proteins: Q13564 and P05067 |
Pubmed |
SVM Score :0.64845796 |
| Our data provide the first in vivo evidence that ASPP 2 is a negative regulator of the neddylation pathway through specific interaction with APP BP 1 and suggest that dysfunction of the APP BP 1 interaction with APP may be one cause of Alzheimer ' s disease . . 0.64845796^^^ |
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| Interacting proteins: Q13564 and P05067 |
Pubmed |
SVM Score :0.80892336 |
| We now demonstrate that APP BP 1 binds to the COOH terminal 31 amino acids of APP ( C 31 ) and colocalizes with APP in a lipid enriched fraction called lipid rafts . 0.80892336^^^ |
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| Interacting proteins: Q13564 and P05067 |
Pubmed |
SVM Score :0.0 |
| APP BP 1 , a novel protein that binds to the carboxyl terminal region of the amyloid precursor protein . beta Amyloid protein precursors ( APPs , 695 770 amino acids ) are the source of the 39 43 amino acid beta amyloid ( A beta ) peptides that comprise diffuse and fibrillar deposits in the cerebral cortex and vasculature of Alzheimer ' s disease brains . ^^^ This ubiquitously expressed 59 kDa APP binding protein , called APP BP 1 , is 61 % similar to a protein encoded by the Arabidopsis AXR 1 gene , required for normal response to the hormone auxin , and is a relative of the ubiquitin activating enzyme E1 . . ^^^ |
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| Interacting proteins: Q13564 and P05067 |
Pubmed |
SVM Score :0.0 |
| The other proteins interacting with the cytosolic domain of APP are the G ( o ) heterotrimeric protein , APP BP 1 and X 11 . ^^^ |
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| Interacting proteins: Q13564 and P05067 |
Pubmed |
SVM Score :0.0 |
| The amyloid precursor protein binding protein APP BP 1 drives the cell cycle through the S M checkpoint and causes apoptosis in neurons . ^^^ APP BP 1 binds to the amyloid precursor protein ( APP ) carboxyl terminal domain . ^^^ Recent work suggests that APP BP 1 participates in a novel ubiquitinylation related pathway involving the ubiquitin like molecule NEDD 8 . ^^^ We show here that , in vivo in mammalian cells , APP BP 1 interacts with hUba 3 , its presumptive partner in the NEDD 8 activation pathway , and that the APP BP 1 binding site for hUba 3 is within amino acids 443 479 . ^^^ We also provide evidence that the human APP BP 1 molecule can rescue the ts 41 mutation in Chinese hamster cells . ^^^ |
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