| Interacting proteins: Q13563 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| Independent yeast two hybrid screens using the COOH terminal region of either CD2AP or polycystin 2 as bait identified the COOH termini of polycystin 2 and CD2AP , respectively , as strong interacting partners . ^^^ This interaction was confirmed in cultured cells by co immunoprecipitation of endogenous polycystin 2 with endogenous CD2AP and vice versa . ^^^ CD2AP shows a diffuse reticular cytoplasmic and perinuclear pattern of distribution , similar to polycystin 2 , in cultured cells , and the two proteins co localize by indirect double immunofluorescence microscopy . ^^^ Such a function fits well with that hypothesized for the polycystin proteins in renal tubular epithelial cells , and the present findings suggest that CD2AP has a role in polycystin 2 function . . ^^^ In vivo interaction of the adapter protein CD 2 associated protein with the type 2 polycystic kidney disease protein , polycystin 2 . ^^^ |
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| Interacting proteins: Q13563 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| CD 2 associated protein ( CD2AP ) is an adapter protein associating with several membrane proteins , including nephrin , mutated in congenital nephrotic syndrome of the Finnish type , and polycystin 2 , mutated in type 2 autosomal dominant polycystic kidney disease . ^^^ The present results suggest that CD2AP is involved in the regulation of the actin cytoskeleton and indicate that CD2AP may act as a direct adapter between the actin cytoskeleton and cell membrane proteins , such as nephrin and polycystin 2 . ^^^ CD 2 associated protein ( CD2AP ) is an adapter protein associating with several membrane proteins , including nephrin , mutated in congenital nephrotic syndrome of the Finnish type , and polycystin 2 , mutated in type 2 autosomal dominant polycystic kidney disease . ^^^ |
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