| Interacting proteins: Q13554 and P14921 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that Ca ( 2+ ) signaling also regulates GM CSF transcription negatively through Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMK 2 ) phosphorylation of serines in the autoinhibitory domain for DNA binding of the transcription factor Ets 1 . ^^^ Conversely , Ets 1 with mutated CaMK 2 target serines showed an increase in transactivation of the GM CSF promoter / enhancer . ^^^ Moreover , constitutively active CaMK 2 inhibited transactivation of GM CSF by wild type Ets 1 but not by Ets 1 with mutated CaMK 2 sites . ^^^ Mutation of CaMK 2 target serines in Ets 1 also relieves inhibition of cooperative transactivation of GM CSF with the Runx1 / AML1 transcription factor . ^^^ |
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| Interacting proteins: Q13554 and P14921 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of threonine 38 by ERK1 / 2 activates Ets 1 , whereas phosphorylation of the exon 7 domain by CaMKII or MLCK inhibits Ets 1 DNA binding activity . ^^^ |
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| Interacting proteins: Q13554 and P14921 |
Pubmed |
SVM Score :0.0 |
| The effect of siPalpha on Ets 1 expression could be partially prevented by KN 93 , suggesting that calcium / calmodulin dependent kinase 2 ( CaMKII ) , a modulator of Ets 1 activity , may play a role in PKCalpha dependent Ets 1 regulation . ^^^ |
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