| Interacting proteins: Q13546 and Q99759 |
Pubmed |
SVM Score :0.50061791 |
| We have also shown that MEKK 3 interacts with RIP and directly phosphorylates IKK . 0.50061791^^^ |
|
| Interacting proteins: Q13546 and Q99759 |
Pubmed |
SVM Score :0.60087229 |
| Furthermore , the receptor interacting protein ( RIP ) was found to interact strongly with MEKK 3 during oltipraz induced NF kappaB signaling , implying a role for tumor necrosis factor receptor signaling in the action of oltipraz . 0.60087229^^^ |
|
| Interacting proteins: Q13546 and Q99759 |
Pubmed |
SVM Score :0.75441291 |
| Moreover , endogenous RIP 1 associates with the MAP kinase kinase kinase ( MAP3K ) MEKK 3 in TNF alpha treated cells , and decreased TNF alpha induced p 38 MAP kinase activation is observed in Mekk 3 ( / ) cells . 0.75441291^^^ |
|
| Interacting proteins: Q13546 and Q99759 |
Pubmed |
SVM Score :0.0 |
| Restoration of NF kappaB activation by tumor necrosis factor alpha receptor complex targeted MEKK 3 in receptor interacting protein deficient cells . ^^^ |
|
| Interacting proteins: Q13546 and Q99759 |
Pubmed |
SVM Score :0.0 |
| TAK 1 is recruited to the tumor necrosis factor alpha ( TNF alpha ) receptor 1 complex in a receptor interacting protein ( RIP ) dependent manner and cooperates with MEKK 3 leading to NF kappaB activation . ^^^ Together , we conclude that TAK 1 is recruited to the TNF R 1 complex via RIP and likely cooperates with MEKK 3 to activate NF kappaB in TNF alpha signaling . . ^^^ |
|
| Interacting proteins: Q13546 and Q99759 |
Pubmed |
SVM Score :0.0 |
| As expected , M CSF alone induced the receptor for RANKL ( RANK ) , but also , unexpectedly , other RANK / NFkappaB pathway components ( TRAF2A , PI 3 kinase , MEKK 3 , RIPK 1 ) , providing a molecular explanation for the synergy of M CSF and RANKL . ^^^ |
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