| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| Moreover , NF kappaB activation induced by overexpression of the TNF receptor associated proteins TNF receptor associated death domain protein ( TRADD ) , receptor interacting protein ( RIP ) , and TNF recep tor associated factor 2 ( TRAF 2 ) was also inhibited by expression of A 20 , whereas NF kappaB activation induced by overexpression of NF kappaB inducing kinase ( NIK ) or the human T cell leukemia virus type 1 ( HTLV 1 ) Tax was unaffected . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| Expression in cells of kinase deficient NIK mutants fails to stimulate NF kappaB and blocks its induction by TNF , by either of the two TNF receptors or by the receptor CD 95 ( Fas / Apo 1 ) , and by TRADD , RIP and MORT1 / FADD , which are adaptor proteins that bind to these receptors . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| TNFRI has been recently shown to activate NF kappaB through association with TRADD , RIP , and TRAF 2 ; activation of the NF kappaB inducing kinase ( NIK ) ; activation of the IkappaB alpha kinases ( IKKalpha and IKKbeta ) ; and phosphorylation of IkappaB alpha . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| TNF alpha signaling involves the recruitment of at least three proteins ( TRADD , RIP , and TRAF 2 ) to the type 1 TNF alpha receptor tail , leading to the sequential activation of the downstream NF kappaB inducing kinase ( NIK ) and IkappaB specific kinases ( IKKalpha and IKKbeta ) . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| FIP 3 also was shown to bind to other cell proteins , RIP and NIK , which previously had been described as essential components of TNF alpha induced NF kappaB activation . ^^^ In addition , FIP 3 inhibited activation of NF kappaB induced by TNF alpha , the TNFR 1 receptor , RIP , NIK , and IKKbeta , as well as basal levels of endogenous NF kappaB in 293 cells . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| Expression of CIPER induced NF kappaB activation , which was inhibited by dominant negative NIK and a nonphosphorylable IkappaB alpha mutant but not by dominant negative RIP . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| We provide evidence that vFLIPs can also modulate the NF kappaB pathway and physically interact with several signaling proteins , such as the TRAFs , RIP , NIK and the IKKs . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 can interact with multiple proteins known to be involved in the activation of the NF kappaB pathway , including the serine threonine kinases RIP , NIK , IKK 1 and IKK 2 . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that the EGFR associates with NF kappaB inducing kinase ( NIK ) and provide evidence suggesting multiprotein complex formation between the EGFR , RIP , and NIK . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| Moreover , overexpression of CSN 3 also inhibits NF kappaB activation triggered by proteins involved in TNF signaling , including TNF R 1 , TRAF 2 , RIP , and NIK , but not by TRAF 6 , a protein involved in IL 1 signaling . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| Upon recruitment of caspase 8 and RIP , NFkappaB inducing kinase ( NIK ) becomes activated causing NFkappaB activation . ^^^ |
|
| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 and caspase 10 activate NF kappaB through RIP , NIK and IKKalpha kinases . ^^^ The GST pull down assay revealed that , among upstream kinases that activate NF kappaB , only NIK and RIP , but not RICK or IKKalpha / beta , could directly bind to PDCasp8 / 10 . ^^^ Taken together , these results suggest that caspase 8 and 10 have roles in a non or anti apoptotic signaling pathway leading to NF kappaB activation through RIP , NIK and IKKalpha . . ^^^ |
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| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| TNAP specifically inhibits NF kappaB activation induced by tumor necrosis factor ( TNF ) alpha , TNF receptor 1 , TRADD , RIP , TRAF 2 , and NIK but does not affect IKK 1 and IKK 2 mediated NF kappaB activation . ^^^ |
|
| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q99558 |
Pubmed |
SVM Score :0.0 |
| NA |
|