| Interacting proteins: Q8IUC6 and Q13546 |
Pubmed |
SVM Score :0.82723442 |
| TRIF physically interacted with the RHIM containing proteins RIP 1 and RIP 3 , and deletion and mutational analyses revealed that the RHIM in TRIF was essential for TRIF induced apoptosis and contributed to TRIF induced NF kappa B activation . 0.82723442^^^ |
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| Interacting proteins: Q8IUC6 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Trif recruited the kinases receptor interacting protein ( RIP ) 1 and RIP 3 through its RIP homotypic interaction motif . ^^^ In the absence of RIP 1 , TLR 3 mediated signals activating NF kappa B , but not the kinase JNK or interferon beta , were abolished , suggesting that RIP 1 mediates Trif induced NF kappa B activation . ^^^ In contrast , the presence of RIP 3 negatively regulated the Trif RIP 1 induced NF kappa B pathway . ^^^ |
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| Interacting proteins: Q8IUC6 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Specific inhibition of MyD 88 independent signaling pathways of TLR 3 and TLR 4 by resveratrol : molecular targets are TBK 1 and RIP 1 in TRIF complex . ^^^ Together , these results demonstrate that resveratrol specifically inhibits TRIF signaling in the TLR 3 and TLR 4 pathway by targeting TANK binding kinase 1 and RIP 1 in TRIF complex . ^^^ |
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| Interacting proteins: Q8IUC6 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Overexpression of SIKE disrupted the interactions of IKKepsilon or TBK 1 with TRIF , RIG 1 and IRF 3 , components in virus and TLR 3 triggered IRF 3 activation pathways , but did not disrupt the interactions of TRIF with TRAF 6 and RIP , components in TLR 3 triggered NF kappaB activation pathway . ^^^ |
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| Interacting proteins: Q8IUC6 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Using macrophages in which receptor interacting protein 1 ( RIP 1 ) was knocked down by small interfering RNA , and macrophages isolated from Toll / interleukin 1 receptor domain containing adaptor inducing IFN beta ( TRIF ) deficient mice , we found that TRIF and RIP 1 function upstream of ROS production in LPS + Z VAD treated macrophages . ^^^ This paper reveals that TRIF , RIP 1 , and ROS production , as well as PARP activation , are involved in inducing autophagy , which contributes to caspase independent macrophage cell death . . ^^^ |
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| Interacting proteins: Q8IUC6 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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