| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Further analysis of mRNA and protein expression levels of apoptosis signaling molecules FADD , receptor interacting protein , hematopoietic cell protein tyrosine phosphatase , Fas associated phosphatase 1 , FLICE , bel 2 , bcl xL , and , bax alpha showed that only the expression level of bcl xL correlated with T cell resistance to CD 95 mediated apoptosis ( day 1 T cells : bcl xhiL ; day 6 T cells : bcl XloL ) . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that the proteolytic cleavage of receptor interacting protein ( RIP ) by caspase 8 during TNF induced apoptosis abrogates the stimulatory role of RIP on TNF induced NF kappaB activation . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Ribonuclease protection assays demonstrated that increases in mRNA levels of the early response protooncogenes c jun , junB , fra 1 , and fra 2 accompanied cell proliferation at low concentrations of PM whereas apoptotic concentrations of PM caused transient increases in expression of fos and jun family members and dose responsive increases in mRNA levels of receptor interacting protein , Fas associated death domain , and caspase 8 . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Relish is processed in order to translocate to the nucleus , and this cleavage is dependent on both Dredd , an apical caspase related to caspase 8 of mammals , and the fly Ikappa B kinase complex ( dmIKK ) . dTAK 1 , a MAPKKK , functions upstream of the dmIKK complex and downstream of Imd , a protein with a death domain similar to that of mammalian receptor interacting protein ( RIP ) . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This leads to recruitment of caspase 8 and receptor interacting protein ( RIP ) to the receptor complex . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Thus , the availability of proteins such as receptor interacting protein , Fas associated death domain , and caspase 8 can determine whether TNFR 1 activation will lead to apoptosis or to necrosis . . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Regulation of cell growth and activation of NF kappaB and of c jun N terminal kinase by the TNF super family is mediated through sequential activation / association of a set of cell signaling proteins named TNF receptor associated factors , Fas associated death domain and FADD like ICE , caspases , receptor interacting protein , NF kappaB inducing kinases , and IkappaBalpha kinases . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Both caspase 8 and caspase 3 were partially activated in effector T cells , which was reflected in cleavage of the caspase 8 substrates , c FLIP ( L ) , receptor interacting protein 1 , and to a lesser extent Bid , but not the caspase 3 substrate inhibitor of caspase activated DNase . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Subsequently , additional functions of c FLIP ( L ) were identified through its association with receptor interacting protein ( RIP ) 1 and TNFR associated factor 2 to activate NF kappaB , as well as by its association with and activation of caspase 8 . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This occurs coincidently with the cleavage of two known caspase 8 substrates , c FLIP ( L ) and receptor interacting protein 1 . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NF kappaB protects macrophages from lipopolysaccharide induced cell death : the role of caspase 8 and receptor interacting protein . ^^^ Further , when caspase 8 activation was suppressed , the knock down of receptor interacting protein inhibited the loss of DeltaPsim and necrotic cell death . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| As discussed in this Review , insight gained from these studies indicates that cFLIP and caspase 8 form a heterodimer that ultimately links T cell receptor signalling to activation of nuclear factor kappaB through a complex that includes B cell lymphoma 10 ( BCL 10 ) , mucosa associated lymphoid tissue lymphoma translocation gene 1 ( MALT 1 ) and receptor interacting protein 1 ( RIP 1 ) . . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Cleavage of the death domain kinase RIP by caspase 8 prompts TNF induced apoptosis . ^^^ We report here that the death domain kinase RIP , a key component of the TNF signaling complex , was cleaved by Caspase 8 in TNF induced apoptosis . ^^^ Most importantly , the Caspase 8 resistant RIP mutants protected cells against TNF induced apopotosis . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We show that the serine / threonine kinase RIP that is required for TNF induced NF kappaB activation is processed by caspase 8 into a dominant negative ( DN ) fragment during death receptor induced apoptosis , thereby leading to a blockade of NF kappaB mediated anti apoptotic signals . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| A dominant negative mutant of RIP inhibits FADD and caspase 8 induced but not Casper induced NF kappaB activation . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Transcriptional expression of TNFR 1 ( p 55 ) , as well as that of FLICE , Fas , FADD , DR 3 , FAF , TRADD , and RIP was similar in these cell lines , indicating that the susceptibility to TNFalpha induced apoptosis may not be determined by the constitutive expression level of these factors . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In contrast to Fas associated death domain ( FADD ) or caspase 8 , FADD like interleukin 1 converting enzyme inhibitory protein ( FLIP ) and RIP protein levels rapidly decreased upon treatment with CHX or ActD , indicating that both molecules have a high turnover rate . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 can interact with multiple proteins known to be involved in the activation of the NF kappaB pathway , including the serine threonine kinases RIP , NIK , IKK 1 and IKK 2 . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| To detect the expression of apoptosis related molecules , ribonuclease protection assay was used with specific antisense RNA probes for Fas , Fas ligand , TNFR 1 , TRAIL , FADD , TRADD , RIP , FAF , FAP , and caspase 8 . ^^^ Immunostaining for Fas , Fas ligand , TRAIL , TRADD , RIP , and caspase 8 was also performed . ^^^ Compared with control and contralateral kidneys , the ligated kidneys displayed a dynamic expression of mRNAs for many apoptosis related molecules , which included an up to threefold increase for Fas , Fas ligand , TNF R 1 , TRAIL , TRADD , RIP , and caspase 8 , and an up to twofold increase for FADD and FAP , but there was little change for FAF . ^^^ Although increased expression of TRAIL , TRADD , RIP , and caspase 8 was noted in tubular cells , there was no staining for these molecules in interstitial cells . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Fas triggers an alternative , caspase 8 independent cell death pathway using the kinase RIP as effector molecule . ^^^ Thus , Fas , TRAIL and TNF receptors can initiate cell death by two alternative pathways , one relying on caspase 8 and the other dependent on the kinase RIP . . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| FasL , Fas , FADD , RIP , caspase 8 , caspase 3 , Bid , FLIP ( S+L ) , FLASH and FAP 1 , proteins known to act within the Fas apoptosis cascade , showed no changes in their expression levels in cells treated with butyrate compared with untreated cells . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Jurkat cell lines deficient in RIP , caspase 8 , or FADD were as susceptible as wild type Jurkat cells to HIV 1 cytopathicity . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Alterations are also observed downstream in the signaling cascade , such as the activation of NF kappaB or the overexpression of the death domain kinase RIP and reduced caspase 8 activity . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Here , we show that ectopic expression of the death receptor signaling protein RIP ( receptor interactive protein ) triggers apoptosis via a FAS associated death domain protein ( FADD ) and caspase 8 dependent pathway . ^^^ We conclude that the lethality of the RIP activated cytosolic caspase 8 pathway is augmented by c Myc priming mitochondria to release cytochrome c . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We propose that FLIP ( L ) inhibits caspase 8 release dependent pro apoptotic signals , whereas the single , membrane restricted active site of the FLIP ( L ) caspase 8 heterocomplex is proteolytically active and acts on local substrates such as RIP . . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| After treatment with TRAIL , both TRAIL sensitive and partial resistant clones showed high levels of activation of caspase 3 , caspase 8 , RIP and PARP . ^^^ Our results showed that the expression levels of DR 5 , the activation levels of caspase 8 , 3 and RIP were critical factors in determining TRAIL sensitivities in Jurkat cells . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Analysis of the native TNF signaling complex revealed the recruitment of RIP , TRADD , and TRAF 2 but not FADD or caspase 8 . ^^^ In an in vitro binding assay , the intracellular domain of TNF R 1 bound TRADD , RIP , and TRAF 2 but did not bind FADD or caspase 8 . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 and caspase 10 activate NF kappaB through RIP , NIK and IKKalpha kinases . ^^^ Taken together , these results suggest that caspase 8 and 10 have roles in a non or anti apoptotic signaling pathway leading to NF kappaB activation through RIP , NIK and IKKalpha . . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , TNF induced programmed necrosis was normally inhibited by caspase 8 cleavage of RIP . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NFkappaB activation by Fas is mediated through FADD , caspase 8 , and RIP and is inhibited by FLIP . ^^^ Here , we show that Fas activates NFkappaB via a pathway involving RIP , FADD , and caspase 8 . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This was established by showing that CIN 85 was co precipitated with TNFR 1 , TRADD , cIAP 1 and TARF1 / 2 , but not with FADD , RIP , caspase 8 or TRAF 6 . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The analysed factors included TNF alpha , TNFR 1 , TNF receptor associated death domain ( TRADD ) , caspase 3 , caspase 8 , TNF receptor associated factor 2 ( TRAF 2 ) and receptor interactive protein ( RIP ) , all of which are involved in the TNF alpha / TNFR 1 signalling pathway mediated apoptosis . ^^^ The quantitative RT PCR indicated that the infected muscle tissues up regulate the expression of pro apoptosis genes ( TNF alpha , TNFR 1 and TRADD , caspase 3 and caspase 8 ) , and anti apoptosis genes ( TRAF 2 and RIP ) at the beginning of cyst formation . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Ceramide analogs also induced cell death in Jurkat mutants that are deficient in cell death signaling proteins , including FADD , caspase 8 and 10 , and RIP . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In a second step , TRADD and RIP 1 associate with FADD and caspase 8 , forming a cytoplasmic complex ( complex 2 ) . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The secondary complex retained the DISC components FADD and caspase 8 , but recruited several factors involved in kinase activation by TNF , namely , RIP 1 , TRAF 2 , and NEMO / IKKgamma . ^^^ |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|