| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.57982807 |
| The importance of caspase prodomains in the regulation of apoptosis is further highlighted by the recognition of adapter molecules , such as RAIDD [ receptor interacting protein ( RIP ) associated ICH 1 / CED 3 homologous protein with a death domain ] / CRADD ( caspase and RIP adapter with death domain ) , which binds to the prodomain of caspase 2 and recruits it to the signalling complex . 0.57982807^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.56284459 |
| DAXX and other death receptor associated proteins , which have been reported to bind directly or indirectly to Fas , such as receptor interacting protein ( RIP ) and RIP associated ICH 1 / CED 3 homologous protein with a death domain ( RAIDD ) , were shown to be dispensable for Fas ligand induced apoptosis . . 0.56284459^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.8246933 |
| Here we show that PIDD is a cytoplasmic protein , and that PIDD induced apoptosis and growth suppression in embryonic fibroblasts depend on the adaptor protein receptor interacting protein ( RIP ) associated ICH 1 / CED 3 homologous protein with a death domain ( RAIDD ) . 0.8246933^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.90960631 |
| Expression of receptor interacting protein ( RIP ) associated Ich 1 homologous protein with death domain ( RAIDD ) was increased following seizures , whereas expression of RIP and tumor necrosis factor receptor associated protein with death domain ( TRADD ) , other components thought to be linked to the caspase 2 activation and signaling mechanism , were unchanged . 0.90960631^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| CRADD , a novel human apoptotic adaptor molecule for caspase 2 , and FasL / tumor necrosis factor receptor interacting protein RIP . ^^^ |
|
| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| In support of these observations we found that Bcl 2 and Bcl xL can block caspase 2 and CRADD ( caspase and RIP adaptor with death domain ) induced cell death . ^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Modeling of six homotypic DD interactions involved in the TNF signaling pathway implicates that the DD of RIP ( Receptor interacting protein kinase 1 ) is capable of interacting with the DD of TRADD ( TNFR 1 associated death domain protein ) in two different , exclusive ways : one that subsequently recruits CRADD ( apoptosis / inflammation ) and another that recruits NFkappaB ( survival / proliferation ) . . ^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Here we describe such an adaptor molecule , RAIDD , which has an unusual bipartite architecture comprising a carboxy terminal death domain that binds to the homologous domain in RIP , a serine / threonine kinase component of the death pathway . ^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| RIP also recruits caspase 2 to the TNFR 1 signaling complex via the adaptor protein RAIDD , which contains a DD and a caspase recruiting domain ( CARD ) . ^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor receptor 1 ( TNFR 1 ) and the Fas receptor recruit complexes formed by the interactions between RIP kinase , TRADD , FADD and RAIDD adaptor proteins that contain death domains which in turn recruit other proteins to initiate signaling [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] . ^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the death associated protein 6 ( DAXX ) gene , the caspase 2 ( CASP 2 ) gene , and the RIPK 1 domain containing adapter with death domain ( RAIDD ) gene , which are key genes in other proapoptotic pathways , were also decreased in the MCL samples . ^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| No significant change was detected in Bax , RAIDD ( receptor interacting protein ( RIP ) associated ICH 1 / CED 3 homologus protein with death domain ) , ZIP ( Zipper interacting protein ) kinase and NF kappaB p 65 levels in both regions , although frontal cortex levels of RAIDD , Bcl 2 and p 21 levels tended to increase . ^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Moreover , using the yeast two hybrid system , we tested whether p75NTR intracellular domain was able to dimerize or interact with known DD containing proteins including FADD , RIP , RAIDD and TRADD . ^^^ |
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| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| RAIDD ( receptor interacting protein [ RIP ] associated ICH 1 / CED 3 homologous protein with a death domain ) , a dual domain adaptor protein has been shown to mediate the recruitment of CASPASE 2 to tumour necrosis factor receptor 1 ( TNF R 1 ) signalling complex through RIP kinase . ^^^ |
|
| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Quantitative analysis revealed unaltered levels of Bax and RAIDD ( Receptor interacting protein associated ICH 1 ( caspase 2 ) / CED 3 ( Caenorhabditis elegans death protease 3 ) homologous protein with death domain ) in both regions . ^^^ |
|
| Interacting proteins: P78560 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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