| Interacting proteins: Q13546 and P41279 |
Pubmed |
SVM Score :0.0 |
| The TCR induced pathway leading to serine 536 phosphorylation is regulated by the kinases Cot ( Tpl 2 ) , receptor interacting protein , protein kinase Ctheta , and NF kappaB inducing kinase , but is independent from the phosphatidylinositol 3 kinase / Akt signaling pathway . ^^^ |
|
| Interacting proteins: Q13546 and P41279 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that the activation of Tpl 2 by TNF alpha depends on signals transduced by both TRAF 2 and RIP 1 . ^^^ |
|
| Interacting proteins: Q13546 and P41279 |
Pubmed |
SVM Score :0.0 |
| Here we showed that Tpl 2 activation by TNF alpha signals depends on the integrity of the Tpl 2 interacting proteins RIP 1 and TRAF 2 , which are required for the engagement of the ERK mitogen activated protein kinase pathway . ^^^ However , neither RIP 1 nor TRAF 2 overexpression was sufficient to activate Tpl 2 and ERK . ^^^ These data therefore dissect the TNF receptor 1 proximal events that regulate Tpl 2 and ERK and highlight a role for RIP 1 , TRAF 2 , and Syk in this pathway . . ^^^ |
|
| Interacting proteins: Q13546 and P41279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P41279 |
Pubmed |
SVM Score :0.0 |
| NA |
|