| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.90038994 |
| DAXX and other death receptor associated proteins , which have been reported to bind directly or indirectly to Fas , such as receptor interacting protein ( RIP ) and RIP associated ICH 1 / CED 3 homologous protein with a death domain ( RAIDD ) , were shown to be dispensable for Fas ligand induced apoptosis . . 0.90038994^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Using a genetic selection based on protein protein interaction in yeast , we have identified two gene products that associate with the intracellular domain of Fas : Fas itself , and a novel 74 kDa protein we have named RIP , for receptor interacting protein . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Further analysis of mRNA and protein expression levels of apoptosis signaling molecules FADD , receptor interacting protein , hematopoietic cell protein tyrosine phosphatase , Fas associated phosphatase 1 , FLICE , bel 2 , bcl xL , and , bax alpha showed that only the expression level of bcl xL correlated with T cell resistance to CD 95 mediated apoptosis ( day 1 T cells : bcl xhiL ; day 6 T cells : bcl XloL ) . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| RNA expression of Fas receptor ( CD 95 ) associated proteins ( Fas associated phosphatase 1 / FAP 1 , Fas associating protein with death domain / FADD , and receptor interacting protein / RIP ) in human leukaemia / lymphoma cell lines . mRNA expression of Fas ( CD 95 ) associated proteins [ Fas associating protein with death domain ( FADD ) , receptor interacting protein ( RIP ) , and Fas associated phosphatase 1 ( FAP 1 ) ] has been investigated in 26 Fas positive human leukaemia / lymphoma cell lines . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| To clarify the molecular mechanism of apoptosis susceptibility , mRNA expression of FasR associated proteins [ Fas associating protein with death domain ( FADD ) , receptor interacting protein ( RIP ) , and Fas associated phosphatase 1 ( FAP 1 ) ] has been investigated in IL 2 activated T cells . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| The Fas associated signaling protein receptor interacting protein ( RIP ) was expressed by some Fas expressing cells , whereas Fas associated death domain ( FADD ) was undetectable in the early postnatal cerebral cortex . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| FIP 3 , isolated as a type 2 adenovirus E 3 14 . 7 kDa interacting protein , is an essential component of the multimeric IkappaB alpha kinase ( IKK ) complex and has been shown to interact with various components ( Fas receptor interacting protein , NF kappaB inducing kinase , IKKbeta ) of the NF kappaB activation pathway . ^^^ The amino terminal 119 amino acids were responsible for the FIP 3 IKKbeta and FIP 3 IKKalpha interaction , and the middle of the protein ( amino acids 201 300 ) appeared to be both the FIP 3 self association domain as well as the FIP 3 Fas receptor interacting protein interaction domain . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| These families may include receptor / ligand molecules such as Fas , Fas ligand , tumor necrosis factor receptor 1 ( TNFR 1 ) , and TNF related apoptosis inducing ligand ( TRAIL ) ; signal transduction adapter molecules such as Fas associated death domain ( FADD ) , TNFR 1 associated death domain ( TRADD ) , receptor interacting protein ( RIP ) , Fas associated factor ( FAF ) , and Fas associated phosphatase ( FAP ) ; or effector molecules such as caspases . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| This Fas ligand induced caspase independent death is absent in T cells that are deficient in either Fas associated death domain ( FADD ) or receptor interacting protein ( RIP ) . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| The protein levels of caspase 3 , 8 , and 9 , DFF 45 ( DNA fragmentation factor 45 ) , and FLIP ( Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme inhibitory proteins ) were decreased , whereas those of ARC ( apoptosis repressor with caspase recruitment domain ) and RICK ( Receptor interacting protein ( RIP ) like interacting CLARP kinase ) increased in AD . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| These proteins included Fas , zinc finger protein ( ZNF ) , RAB , and Ah receptor interacting protein ( AIP ) . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Ribonuclease protection assays demonstrated that increases in mRNA levels of the early response protooncogenes c jun , junB , fra 1 , and fra 2 accompanied cell proliferation at low concentrations of PM whereas apoptotic concentrations of PM caused transient increases in expression of fos and jun family members and dose responsive increases in mRNA levels of receptor interacting protein , Fas associated death domain , and caspase 8 . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| We detected Fas Fas ligand binding and assembly of death inducing signaling complexes ( DISCs ) [ Fas , Fas associated protein with death domain , and procaspase 8 or procaspase 10 ; receptor interacting protein ( RIP ) RIP associated interleukin 1beta converting enzyme and CED 3 homolog 1 / Ced 3 homologous protein with a death domain procaspase 2 ] by immunoprecipitation and immunoblotting within mouse parietal cortex after controlled cortical impact . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Sensitization of PSC with culture duration was accompanied by increased expression of CD 95 and TRAIL receptor 2 and no alterations of Flip expression or protein kinase B phosphorylation but was paralleled by the appearance of a COOH terminal cleavage product of receptor interacting protein . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Kupffer cell induced hepatic stellate cell killing required hepatic stellate cell / Kupffer cell contacts and was prevented by dexamethasone , prostaglandin E ( 2 ) , tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) receptor 2 antagonists , and down regulation of receptor interacting protein , but not by antioxidants , tumor necrosis factor receptor , or CD 95 antagonists . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Furthermore , IL 12 induced apoptosis was associated with caspase 3 , caspase 2 , caspase 7 , DNA fragmentation factor 45 ( DFF 45 ) and Fas associated death domain ( FADD ) whereas TNF receptor associated death domain ( TRADD ) and receptor interacting protein ( RIP ) were not . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| CD 4 DC mediated cell death resembled apoptosis , as evidenced by outer membrane phosphatidylserine exposure and nuclear fragmentation in target cells , but was caspase as well as Fas associated death domain and receptor interacting protein independent . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Isolation and characterization of death domain ( TNF RI , Fas , TRADD , FADD / MORT 1 , RIP ) and TRAF domain containing proteins ( TRAF 1 , TRAF 2 , TRAF 3 ) have partially bridged a large molecular gap within one of several signaling pathways which originate at the plasma membrane and terminate in the nucleus . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Here , we show that TRADD interacts strongly with RIP , another death domain protein that was shown previously to associate with Fas antigen . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| With use of the yeast two hybrid system , the proteins RIP and FADD / MORT1 have been shown to interact with the `` death domain ' ' of the Fas receptor . ^^^ Furthermore , RIP and FADD appear to activate different apoptotic pathways since RIP is able to induce cell death in a cell line that is resistant to the apoptotic effects of Fas , tumor necrosis factor , and FADD . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| The RIP deficient cell line is susceptible to apoptosis initiated by anti CD 95 antibodies . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Expression in cells of kinase deficient NIK mutants fails to stimulate NF kappaB and blocks its induction by TNF , by either of the two TNF receptors or by the receptor CD 95 ( Fas / Apo 1 ) , and by TRADD , RIP and MORT1 / FADD , which are adaptor proteins that bind to these receptors . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| FIP 2 by itself does not cause cell death ; however , it can reverse the protective effect of E 3 14 . 7K on cell killing induced by overexpression of the intracellular domain of the 55 kDa TNF receptor or by RIP , a death protein involved in the TNF alpha and Fas apoptosis pathways . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| The death domain serine / threonine kinase RIP interacts with the death receptors Fas and tumor necrosis receptor 1 ( TNFR 1 ) . ^^^ In contrast to a normal thymic anti Fas response , rip / cells are highly sensitive to TNFalpha induced cell death . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Wild type and TNFR 2 deficient OT 1 cells were activated and then deleted when transferred into RIP mOVA mice , whereas CD 95 deficient OT 1 cells were not susceptible to deletion by cross presentation . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| The intracellular domain of Fas interacts with several proteins including FADD ( MORT 1 ) , DAXX , RIP , FAF 1 , FAP 1 and Sentrin . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| The testicular expression of RIP and FAP 1 , components of the Fas activating complex , increased after exposure to mono ( 2 ethylhexyl ) phthalate ( MEHP ) , a Sertoli cell toxicant which induces massive germ cell death . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor receptor 1 ( TNFR 1 ) and the Fas receptor recruit complexes formed by the interactions between RIP kinase , TRADD , FADD and RAIDD adaptor proteins that contain death domains which in turn recruit other proteins to initiate signaling [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitates of fas antigen from membrane preparations made from control or castrated rat prostates were analyzed for coprecipitation of FADD and RIP proteins to assess the activation state of the fas antigen before and after castration . ^^^ Immunoprecipitates of fas antigen from membranes of ventral prostates from castrated rats contained significantly increased amounts of both FADD and RIP proteins when compared to those of intact or control operated rats . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analyses revealed that Fas ( CD95 / APO 1 ) , Fas ligand ( FasL ) and two downstream mediators , RIP and caspase 3 , ( CPP 32 , YAMA , Apopain ) were increased in GCV treated HSVtk transduced tumor cells the cell cycle arrest and before apoptosis . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that cleavage of RIP is part of an amplification loop which is triggered by Fas and most likely by other death receptors . . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Transcriptional expression of TNFR 1 ( p 55 ) , as well as that of FLICE , Fas , FADD , DR 3 , FAF , TRADD , and RIP was similar in these cell lines , indicating that the susceptibility to TNFalpha induced apoptosis may not be determined by the constitutive expression level of these factors . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| This region is similar , but distinct , to the death domain found in many pro apoptotic receptors and adapter proteins , including FAS , FADD , TNFR 1 , and RIP . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Fas resistant VSMCs expressed surface Fas and could recruit RIP , indicating that functional receptor complexes were formed . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Fas recruited FLIP interacts with TNF receptor associated factors 1 and 2 , as well as with the kinases RIP and Raf 1 , resulting in the activation of the NF kappaB and extracellular signal regulated kinase ( Erk ) signaling pathways . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Here , we report that metabolic inhibitors such as cycloheximide ( CHX ) or actinomycin D ( ActD ) sensitize for CD 95 induced apoptosis by strongly down regulating FLIP and RIP expression . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| The C terminal fragment of RIP also enhanced the association between TNFR 1 and death domain proteins including TNFR 1 associated death domain ( TRADD ) and Fas associated death domain ( FADD ) , resulting in the activation of caspase 8 and stimulation of apoptosis . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Our aim was to expand these searches by looking for mutations in the death domains of FAS , FADD , TNFR , TRADD , and RIP , in the promoter region of FAS , and in the protease domain of caspase 10 , in a larger variety of hematological malignancies , some of which express an apoptosis resistant phenotype . ^^^ CONCLUSIONS : These observations imply that mutations in the death domains of FAS , FADD , TNFR , TRADD , and RIP and in the protease domain of caspase 10 are not a major cause for failure of apoptosis in hematological malignancies , mainly CML and CLL . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| This activity is independent of FADD DN ' s ability to bind to three known interacting proteins , Fas , TRADD or RIP suggesting that it is distinct from FADD ' s functions at activated death receptors . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| FasL , Fas , FADD , RIP , caspase 8 , caspase 3 , Bid , FLIP ( S+L ) , FLASH and FAP 1 , proteins known to act within the Fas apoptosis cascade , showed no changes in their expression levels in cells treated with butyrate compared with untreated cells . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Unlike Fas associated death domain , rip does not regulate T cell proliferation , as rip / T cells respond to polyclonal activators . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Moreover , FLIP ( L ) expression favors receptor interacting kinase ( RIP ) processing within the Fas signaling complex . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Ligation of CD 95 instigates the formation of a complex known as the `` death inducing signaling complex ' ' or DISC , which is composed of molecules including FADD ( Fas associated with death domain ) and RIP ( receptor interacting kinase ) , as well as procaspases 8 and 10 , and a caspase 8 like molecule that lacks proteolytic activity called c FLIP . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| RIP is a major component of the death receptor complex and has been shown to interact with Fas and tumor necrosis factor receptor 1 through its binding to adapter proteins . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NFkappaB activation by Fas is mediated through FADD , caspase 8 , and RIP and is inhibited by FLIP . ^^^ Here , we show that Fas activates NFkappaB via a pathway involving RIP , FADD , and caspase 8 . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Lack of TNFR 1 signaling also affected the expression of apoptosis / cell death related genes ( Fas , Rip , p 53 ) , matrix metalloproteinases ( MMP 3 , MMP 9 , MMP 12 ) , and their inhibitors ( TIMP 1 ) , suggesting a role of TNFR 1 in extracellular matrix remodeling after injury . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| Whereas exposure to 3 Cl AHPC results in NF kappaB activation , it inhibits the expression of XIAP , c IAP 1 , and Bcl 10 ( L ) and enhances the expression of proapoptotic molecules , including the death receptors DR 4 and DR 5 as well as Fas and Rip 1 . ^^^ |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|