| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.92387247 |
| Recently , Hsp 90 has been shown to play important antiapoptotic roles through binding with Apaf 1 , RIP and kinase domain of IKKalpha / beta . 0.92387247^^^ |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| Radicicol also specifically binds to yeast Hsp 90 , Escherichia coli HtpG , and a newly described tumor necrosis factor receptor interacting protein , Trap 1 , with greater homology to bacterial HtpG than to Hsp 90 . ^^^ |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| Disruption of hsp 90 function results in degradation of the death domain kinase , receptor interacting protein ( RIP ) , and blockage of tumor necrosis factor induced nuclear factor kappaB activation . ^^^ |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| However , pretreatment of the cells with the Hsp 90 inhibitor geldanamycin , which leads to proteasome mediated degradation of receptor interacting protein 1 ( RIP 1 ) , reverts FKBP FADD induced necrosis to apoptosis . ^^^ |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| However , expression of the adaptor protein RIP , which is essential for IKK activation by TNFalpha , was decreased in cells exposed to H2O2 , and its chaperone Hsp 90 was cleaved . ^^^ |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| Cleavage and degradation of TNF pathway components TNFR 1 , RIP , and Hsp 90 were observed in l mimosine and H ( 2 ) O ( 2 ) treated cells indicating a putative mechanism for selective inhibition of TNF but not IL 1beta induced IKK activation . . ^^^ |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| Previous studies suggest that heat shock protein 90 ( Hsp 90 ) regulates the stability and function of receptor interaction proteins ( RIP ) and IkappaB kinase beta ( IKKbeta ) , the key components of the TNF induced NF kappaB activation pathway . ^^^ |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P08238 |
Pubmed |
SVM Score :0.0 |
| NA |
|