| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.6067298 |
| Here we show that upon TNFalpha binding , TNFR 1 translocates to cholesterol and sphingolipid enriched membrane microdomains , termed lipid rafts , where it associates with the Ser / Thr kinase RIP and the adaptor proteins TRADD and TRAF 2 , forming a signaling complex . 0.6067298^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| TIAF 1 inhibits the cytotoxic effects of TNF alpha and overexpressed TNF receptor adaptors TRADD , FADD , and RIP . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that the activation of Tpl 2 by TNF alpha depends on signals transduced by both TRAF 2 and RIP 1 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| RIP mediates tumor necrosis factor receptor 1 activation of NF kappaB but not Fas / APO 1 initiated apoptosis . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2 induced cell death . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| In cells deficient for receptor interacting protein expression TNF , but not PMA induced TRAIL expression was blocked . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| We also show that TAB 2 binds to polyubiquitinated RIP following TNFalpha stimulation . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Transgenic mice expressing both LCMV gp and TNF alpha under the control of the RIP were infected with vacc gp , and 50 % of RIP gp / TNF alpha transgenic animals became hyperglycemic . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| To analyze the effects of TNF alpha in insulin dependent diabetes mellitus ( IDDM ) , we have generated nonobese diabetic ( NOD ) transgenic mice expressing TNF alpha under the control of the rat insulin 2 promoter ( RIP ) . ^^^ To determine the mechanism of TNF alpha action , splenic cells from control NOD and RIP TNF alpha mice were adoptively transferred to NOD SCID recipients . ^^^ In contrast to the induction of diabetes by splenic cells from control NOD mice , splenic cells from RIP TNF alpha transgenic mice did not induce diabetes in NOD SCID recipients . ^^^ Diabetes was induced however , in the RIP TNF alpha transgenic mice when CD8+ diabetogenic cloned T cells or splenic cells from diabetic NOD mice were adoptively transferred to these mice . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| FIP 2 by itself does not cause cell death ; however , it can reverse the protective effect of E 3 14 . 7K on cell killing induced by overexpression of the intracellular domain of the 55 kDa TNF receptor or by RIP , a death protein involved in the TNF alpha and Fas apoptosis pathways . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| TNF alpha signaling involves the recruitment of at least three proteins ( TRADD , RIP , and TRAF 2 ) to the type 1 TNF alpha receptor tail , leading to the sequential activation of the downstream NF kappaB inducing kinase ( NIK ) and IkappaB specific kinases ( IKKalpha and IKKbeta ) . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| FIP 3 also was shown to bind to other cell proteins , RIP and NIK , which previously had been described as essential components of TNF alpha induced NF kappaB activation . ^^^ In addition , FIP 3 inhibited activation of NF kappaB induced by TNF alpha , the TNFR 1 receptor , RIP , NIK , and IKKbeta , as well as basal levels of endogenous NF kappaB in 293 cells . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Examination of Stat 1 deficient cells showed an apparent increase in TNF alpha induced TRADD RIP and TRADD TRAF 2 complex formation , while interaction between TRADD and FADD was unaffected . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Receptor interacting protein ( RIP ) , a death domain serine / threonine kinase , has been shown to play a critical role in tumor necrosis factor alpha ( TNF alpha ) induced activation of the nuclear factor kappaB signaling pathway . ^^^ We also demonstrated that the TNF alpha induced MEKK 1 activation was defective in RIP deficient Jurkat cells . ^^^ Taken together , our results suggest that RIP phosphorylates and activates MEKK 1 and that RIP is involved in TNF alpha induced MEKK 1 activation . . ^^^ Receptor interacting protein ( RIP ) , a death domain serine / threonine kinase , has been shown to play a critical role in tumor necrosis factor alpha ( TNF alpha ) induced activation of the nuclear factor kappaB signaling pathway . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| To discover TNF alpha induced factors that regulate GR activity at the coactivator level , we performed yeast two hybrid screening using the NRB domain of the glucocorticoid receptor interacting protein 1 ( GRIP 1 ) as bait . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| In the present study , we show that the TNF alpha induced accumulation of hypoxia inducible factor 1 alpha ( HIF 1 alpha ) protein in normoxic cells is RIP dependent . ^^^ In contrast , RIP ( / ) cells were unable to induce HIF 1 alpha in response to TNF alpha . ^^^ |
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| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The cytokine tumor necrosis factor alpha ( TNF alpha ) stimulates the NF kappaB , SAPK / JNK , and p 38 mitogen activated protein ( MAP ) kinase pathways by recruiting RIP 1 and TRAF 2 proteins to the tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^ In transfection studies , RIP 1 and TRAF 2 stimulate p 38 MAP kinase activation , and dominant negative forms of RIP 1 and TRAF 2 inhibit TNF alpha induced p 38 MAP kinase activation . ^^^ We found TNF alpha induced p 38 MAP kinase activation and interleukin 6 ( IL 6 ) production impaired in rip 1 ( / ) murine embryonic fibroblasts ( MEF ) but unaffected in traf 2 ( / ) MEF . ^^^ Thus , RIP 1 is a specific mediator of the p 38 MAP kinase response to TNF alpha . ^^^ These studies suggest that TNF alpha induced activation of p 38 MAP kinase and SAPK / JNK pathways bifurcate at the level of RIP 1 and TRAF 2 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| In response to tumor necrosis factor alpha ( TNF alpha ) , we find Rip 1 phosphorylated and ubiquitinated , suggesting that Rip 1 phosphorylation may stimulate its ubiquitination . ^^^ To address the contribution of the kinase activity of Rip 1 to its ubiquitination and to TNF alpha signaling , we introduced wild type Rip 1 and a kinase inactive form of Rip 1 , Rip1D138N , into rip 1 / murine embryonic fibroblast cells by retroviral infection . ^^^ TNF alpha induced ubiquitination of Rip 1 is observed in Rip1D138N cells , supporting the argument that Rip 1 autophosphorylation is not required for Rip 1 ubiquitination . ^^^ TNF alpha induced Ikk and p 38 MAP kinase activation is normal , and the Rip1D138N cells are resistant to TNF alpha induced cell death , indicating that the kinase activity of Rip 1 is not required to mediate its antiapoptotic functions . ^^^ In the absence of Traf 2 , TNF alpha induced ubiquitination of Rip 1 is impaired , suggesting that Traf 2 may be the E 3 ubiquitin ligase responsible for the TNF alpha dependent , ubiquitination of Rip 1 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Arsenic also activated caspase 3 resulting in the cleavage of poly ( ADP ribose ) polymerase ( PARP ) and Fas / TNF alpha related receptor interacting protein ( RIP ) . ^^^ This study first shows that arsenic induces apoptotic signaling in MM through the cleavage of TNF alpha related receptor interacting protein ( RIP ) . ^^^ RIP is a key downstream protein in FasL / TNF alpha / TRAIL induced apoptosis and a major antiapoptotic adaptor of pathways through NF kappa B and JNK . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| However , TRADD and RIP , which are essential for the TNF alpha induced NF kappaB activation , were not involved in the FasL induced NF kappaB activation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Receptor interacting protein ( RIP ) plays a critical role in tumor necrosis factor alpha ( TNF alpha ) induced NF kappaB activation . ^^^ However , the mechanism by which RIP mediates TNF alpha induced signal transduction is not fully understood . ^^^ In these cells , MEKK 3 DD substitutes for RIP and directly associates with TRADD in TNF receptor complexes following TNF alpha stimulation . ^^^ In contrast , expression of a fusion protein composed of NEMO , a component of the IkappaB kinase complex , and the death domain of RIP ( NEMO DD ) can not restore TNF alpha induced NF kappaB activation in RIP deficient cells . ^^^ These results indicate that the role of RIP is to specifically recruit MEKK 3 to the TNF alpha receptor complex , whereas the forced recruitment of NEMO to the TNF alpha receptor complex is insufficient for TNF alpha induced NF kappaB activation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Rip 1 is required for IkappaB kinase activation in response to tumor necrosis factor alpha ( TNF alpha ) and has been implicated in the Toll like receptor 3 ( TLR 3 ) response to double stranded RNA . ^^^ Cytokine production is impaired when rip 1 / cells are treated with TNF alpha , poly ( 1 C ) , or lipopolysaccharide , implicating Rip 1 in the Trif dependent TLR 3 and TLR 4 pathways . ^^^ In the TNF alpha pathway , Rip 1 interacts with the E 3 ubiquitin ligase Traf 2 and is modified by polyubiquitin chains . ^^^ These studies suggest that Rip 1 uses a similar , ubiquitin dependent mechanism to activate IkappaB kinase beta in response to TNF alpha and TLR 3 ligands . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The analysed factors included TNF alpha , TNFR 1 , TNF receptor associated death domain ( TRADD ) , caspase 3 , caspase 8 , TNF receptor associated factor 2 ( TRAF 2 ) and receptor interactive protein ( RIP ) , all of which are involved in the TNF alpha / TNFR 1 signalling pathway mediated apoptosis . ^^^ The quantitative RT PCR indicated that the infected muscle tissues up regulate the expression of pro apoptosis genes ( TNF alpha , TNFR 1 and TRADD , caspase 3 and caspase 8 ) , and anti apoptosis genes ( TRAF 2 and RIP ) at the beginning of cyst formation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| TAK 1 is recruited to the tumor necrosis factor alpha ( TNF alpha ) receptor 1 complex in a receptor interacting protein ( RIP ) dependent manner and cooperates with MEKK 3 leading to NF kappaB activation . ^^^ Receptor interacting protein ( RIP ) plays a critical role in tumor necrosis factor alpha ( TNF alpha ) induced IkappaB kinase ( IKK ) activation and subsequent activation of transcription factor NF kappaB . ^^^ However , the molecular mechanism by which RIP mediates TNF alpha induced NF kappaB activation is not completely defined . ^^^ In this study , we have found that TAK 1 is recruited to the TNF alpha receptor complex in a RIP dependent manner following the stimulation of TNF alpha receptor 1 ( TNF R 1 ) . ^^^ Moreover , a forced recruitment of TAK 1 to TNF R 1 in the absence of RIP is sufficient to mediate TNF alpha induced NF kappaB activation , indicating that the major function of RIP is to recruit its downstream kinases to the TNF R 1 complex . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Furthermore , down regulating the receptor interacting protein , RIP , with geldanamycin treatment , which is essential for TNF alpha signalling , markedly inhibited AICD in FADD ( / ) Jurkat T cells . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| TNF alpha stimulates the JNK , ERK , and p 38 mitogen activated protein kinases and the NF kappaB pathway by recruiting RIP 1 and TRAF 2 to the TNF receptor 1 . ^^^ Here we showed that Tpl 2 activation by TNF alpha signals depends on the integrity of the Tpl 2 interacting proteins RIP 1 and TRAF 2 , which are required for the engagement of the ERK mitogen activated protein kinase pathway . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of mRNA for TNF alpha receptors ( TNFR 1 and TNFR 2 ) and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) , and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase PCR ( RT PCR ) in PBMCs from control and RA cases . ^^^ PBMCs of RA patients showed a significant increase in TNF alpha and TNFR 1 expression as compared with that from control subjects along with significantly increased constitutive expression of TRADD , RIP , and TRAF 2 mRNA . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| RIP also interacts weakly with the p 55 tumor necrosis factor receptor ( TNFR 1 ) intracellular domain , but not with a mutant version of Fas corresponding to the murine lprcg mutation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Furthermore , RIP and FADD appear to activate different apoptotic pathways since RIP is able to induce cell death in a cell line that is resistant to the apoptotic effects of Fas , tumor necrosis factor , and FADD . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| CRADD , a novel human apoptotic adaptor molecule for caspase 2 , and FasL / tumor necrosis factor receptor interacting protein RIP . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor receptor 1 ( TNFR 1 ) and the Fas receptor recruit complexes formed by the interactions between RIP kinase , TRADD , FADD and RAIDD adaptor proteins that contain death domains which in turn recruit other proteins to initiate signaling [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| RIP 3 binds RIP through its unique C terminal segment and by virtue of this interaction is recruited to the tumor necrosis factor ( TNF ) receptor 1 signaling complex . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The Epstein Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor associated proteins TRADD and receptor interacting protein ( RIP ) but does not induce apoptosis or require RIP for NF kappaB activation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Radicicol also specifically binds to yeast Hsp 90 , Escherichia coli HtpG , and a newly described tumor necrosis factor receptor interacting protein , Trap 1 , with greater homology to bacterial HtpG than to Hsp 90 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| LMP 1 spontaneously aggregates in the plasma membrane and enables two transformation effector sites ( TES 1 and TES 2 ) within the 200 amino acid cytoplasmic carboxyl terminus to constitutively engage the tumor necrosis factor receptor ( TNFR ) associated factors TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 5 and the TNFR associated death domain proteins TRADD and RIP , thereby activating NF kappaB and c Jun N terminal kinase ( JNK ) . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Double transgenic mice [ rat insulin promoter ( RIP ) tumor necrosis factor ( TNF ) and RIP CD 80 ] whose pancreatic beta cells release TNF and bear CD 80 all develop an acute early ( 6 wk ) and lethal diabetes mediated by CD 8 T cells . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Disruption of hsp 90 function results in degradation of the death domain kinase , receptor interacting protein ( RIP ) , and blockage of tumor necrosis factor induced nuclear factor kappaB activation . ^^^ The death domain kinase , receptor interacting protein ( RIP ) , is one of the major components of the tumor necrosis factor receptor 1 ( TNFR 1 ) complex and plays an essential role in tumor necrosis factor ( TNF ) mediated nuclear factor kappaB ( NF kappaB ) activation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The atypical protein kinase C ( aPKC ) interacting protein , p 62 , has previously been shown to interact with RIP , linking these kinases to NF kappaB activation by tumor necrosis factor alpha ( TNFalpha ) . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Thus , the proximity of RICK , RIP , and IKK complexes may play an important role for NF kappaB activation during Nod 1 oligomerization or trimerization of the tumor necrosis factor alpha receptor . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| These families may include receptor / ligand molecules such as Fas , Fas ligand , tumor necrosis factor receptor 1 ( TNFR 1 ) , and TNF related apoptosis inducing ligand ( TRAIL ) ; signal transduction adapter molecules such as Fas associated death domain ( FADD ) , TNFR 1 associated death domain ( TRADD ) , receptor interacting protein ( RIP ) , Fas associated factor ( FAF ) , and Fas associated phosphatase ( FAP ) ; or effector molecules such as caspases . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| RIP is also required for necrotic death induced by tumor necrosis factor ( TNF ) and TNF related apoptosis inducing ligand ( TRAIL ) . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Expression of receptor interacting protein ( RIP ) associated Ich 1 homologous protein with death domain ( RAIDD ) was increased following seizures , whereas expression of RIP and tumor necrosis factor receptor associated protein with death domain ( TRADD ) , other components thought to be linked to the caspase 2 activation and signaling mechanism , were unchanged . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Rather , CARDINAL potently suppressed NF kappaB activation associated with overexpression of TRAIL R 1 , TRAIL R 2 , RIP , RICK , Bcl 10 , and TRADD , or through ligand induced stimulation of the interleukin 1 or tumor necrosis factor receptors . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Receptor interacting protein ( RIP ) , a Ser / Thr kinase component of the tumor necrosis factor ( TNF ) receptor 1 signaling complex , mediates activation of the nuclear factor kappaB ( NF kappaB ) pathway . ^^^ Receptor interacting protein ( RIP ) , a Ser / Thr kinase component of the tumor necrosis factor ( TNF ) receptor 1 signaling complex , mediates activation of the nuclear factor kappaB ( NF kappaB ) pathway . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| A novel zinc finger protein interacts with receptor interacting protein ( RIP ) and inhibits tumor necrosis factor ( TNF ) and IL 1 induced NF kappa B activation . ^^^ Receptor interacting protein ( RIP ) is a serine / threonine protein kinase that is critically involved in tumor necrosis factor receptor 1 ( TNF R 1 ) induced NF kappa B activation . ^^^ Receptor interacting protein ( RIP ) is a serine / threonine protein kinase that is critically involved in tumor necrosis factor receptor 1 ( TNF R 1 ) induced NF kappa B activation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Using a subtractive cDNA library hybridization approach , we found that receptor interacting protein 2 ( RIP 2 ) , a tumor necrosis factor receptor 1 ( TNFR 1 ) associated factor , is a novel early acting gene that decreases markedly in expression during myogenic differentiation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| A 20 inhibits tumor necrosis factor ( TNF ) alpha induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Kupffer cell induced hepatic stellate cell killing required hepatic stellate cell / Kupffer cell contacts and was prevented by dexamethasone , prostaglandin E ( 2 ) , tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) receptor 2 antagonists , and down regulation of receptor interacting protein , but not by antioxidants , tumor necrosis factor receptor , or CD 95 antagonists . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Geldanamycin pretreatment led to a proteasome dependent decrease in the levels of several TNFR 1 interacting proteins including the kinases receptor interacting protein , inhibitor of kappa B kinase alpha , inhibitor of kappa B kinase beta , and to a lesser extent the adaptors NF kappaB essential modulator and tumor necrosis factor receptor associated factor 2 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Of note , TNF induced NF kappaB DNA binding activity and activation of IkappaB kinases ( IKKs ) were markedly impaired in FAK / cells , whereas the expression of TNF receptor 1 or other signaling molecules such as receptor interacting protein ( RIP ) , tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , IKKalpha , IKKbeta , and IKKgamma was unchanged . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| A role for tumor necrosis factor receptor 2 and receptor interacting protein in programmed necrosis and antiviral responses . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Receptor interacting protein ( RIP ) is a serine / threonine protein kinase that is critically involved in tumor necrosis factor receptor 1 ( TNF R 1 ) induced NF kappaB activation . ^^^ Receptor interacting protein ( RIP ) is a serine / threonine protein kinase that is critically involved in tumor necrosis factor receptor 1 ( TNF R 1 ) induced NF kappaB activation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| LMP 1 activates the IkappaB kinase complex and NF kappaB through two cytoplasmic signaling domains that engage tumor necrosis factor receptor associated factor ( TRAF ) 1 / 2 / 3 / 5 or TRADD and RIP . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| In this study , we utilized gene knockout mouse embryonic fibroblasts cells and found that tumor necrosis factor receptor ( TNFR ) 1 mediates TNF induced necrotic cell death , and that RIP , FADD , and TRAF 2 are critical components of the signaling cascade of this TNF induced necrotic cell death . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Kinase RIP 3 is dispensable for normal NF kappa Bs , signaling by the B cell and T cell receptors , tumor necrosis factor receptor 1 , and Toll like receptors 2 and 4 . ^^^ RIP 3 deficient cells showed normal sensitivity to a variety of apoptotic stimuli and were indistinguishable from wild type cells in their ability to activate NF kappa B signaling in response to the following : human tumor necrosis factor ( TNF ) , which selectively engages mouse TNF receptor 1 ; cross linking of the B or T cell antigen receptors ; peptidoglycan , which activates Toll like receptor 2 ; and lipopolysaccharide ( LPS ) , which stimulates Toll like receptor 4 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the receptor interacting protein ( RIP ) was found to interact strongly with MEKK 3 during oltipraz induced NF kappaB signaling , implying a role for tumor necrosis factor receptor signaling in the action of oltipraz . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| RIP is a major component of the death receptor complex and has been shown to interact with Fas and tumor necrosis factor receptor 1 through its binding to adapter proteins . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Data from this study suggest that receptor interacting protein ( RIP ) and tumor necrosis factor receptor ( TNFR ) associated factor 2 ( TRAF 2 ) , two key effector molecules of TNF signaling , are essential for ROS induced cell death . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| TNAP specifically inhibits NF kappaB activation induced by tumor necrosis factor ( TNF ) alpha , TNF receptor 1 , TRADD , RIP , TRAF 2 , and NIK but does not affect IKK 1 and IKK 2 mediated NF kappaB activation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Receptor interacting protein 3 ( RIP 3 ) , a member of the RIP Ser / Thr kinase family , has been characterized as a pro apoptotic protein involved in the tumor necrosis factor receptor 1 signaling pathway . ^^^ Receptor interacting protein 3 ( RIP 3 ) , a member of the RIP Ser / Thr kinase family , has been characterized as a pro apoptotic protein involved in the tumor necrosis factor receptor 1 signaling pathway . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Although XEDAR induced apoptosis can be blocked by dominant negative Fas associated death domain ( FADD ) protein and FADD small interfering RNA , XEDAR does not directly bind to FADD , tumor necrosis factor receptor associated death domain ( TRADD ) protein , or RIP 1 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The physiological and pathological roles of RIP 2 are mediated through its involvement in multiple NF kappaB activation pathways , including those triggered by tumor necrosis factor ( TNF ) , interleukin 1 ( IL 1 ) , Toll like receptor 2 ( TLR 2 ) , TLR 3 , TLR 4 and Nod 1 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| We previously reported that tumor necrosis factor alpha receptor and Fas associated FLASH interacts with one of the p 160 nuclear receptor coactivators , glucocorticoid receptor interacting protein ( GRIP ) 1 , at its nuclear receptor binding ( NRB ) domain , and that inhibits the transcriptional activity of the glucocorticoid receptor ( GR ) by interfering with association of GR and GRIP 1 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The NZBW strain lacked the FB 1 induced increases in the expression of liver tumor necrosis factor alpha , interferon gamma , receptor interacting protein ( RIP ) , and tumor necrosis factor alpha related apoptosis inducing ligand ( TRAIL ) , observed in CBL . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| We reveal that receptor interacting protein 1 ( RIP 1 ) and tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , are upstream of JNK in PARP 1 hyperactivated cells , because PARP 1 induced JNK activation was attenuated in RIP 1 / and TRAF 2 / mouse embryonic fibroblast cells . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Here we show that tumor necrosis factor alpha induced RIP dependent inhibition of adenine nucleotide translocase ( ANT ) conducted transport of ADP into mitochondria , which resulted in reduced ATP and necrotic cell death . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Ubiquitination of RIP is required for tumor necrosis factor alpha induced NF kappaB activation . ^^^ Stimulation of cells with tumor necrosis factor ( TNFalpha ) triggers a recruitment of various signaling molecules , such as RIP , to the TNFalpha receptor 1 complex , leading to activation of NF kappaB . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The receptor interacting protein kinase 1 ( RIP 1 ) is essential for the activation of nuclear factor kappaB ( NF kappaB ) by tumor necrosis factor alpha ( TNFalpha ) . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Competitive control of independent programs of tumor necrosis factor receptor induced cell death by TRADD and RIP 1 . ^^^ Stimulation of tumor necrosis factor receptor 1 ( TNFR 1 ) can initiate several cellular responses , including apoptosis , which relies on caspases , necrotic cell death , which depends on receptor interacting protein kinase 1 ( RIP 1 ) , and NF kappaB activation , which induces survival and inflammatory responses . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the receptor interacting protein ( RIP ) , a key mediator of tumor necrosis factor induced NF kappaB and JNK activation , plays a key role in IGF 1 receptor signaling . ^^^ Taken together , our results indicate that RIP , a key factor in tumor necrosis factor signaling , also plays a pivotal role in IGF 1 induced JNK activation and cell proliferation . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Phorbol 12 myristate 13 acetate protects against tumor necrosis factor ( TNF ) induced necrotic cell death by modulating the recruitment of TNF receptor 1 associated death domain and receptor interacting protein into the TNF receptor 1 signaling complex : Implication for the regulatory role of protein kinase C . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| METHODS : Two pancreatic beta cell lines , RINm5F and MIN 6 cells , were transfected with a rat insulin promoter ( RIP ) luciferase fusion gene and treated with a combination of cytokines , including 5 ng / mL interleukin 1beta + 10 ng / mL tumor necrosis factor alpha + 25 ng / mL interferon gamma . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Isolation and characterization of death domain ( TNF RI , Fas , TRADD , FADD / MORT 1 , RIP ) and TRAF domain containing proteins ( TRAF 1 , TRAF 2 , TRAF 3 ) have partially bridged a large molecular gap within one of several signaling pathways which originate at the plasma membrane and terminate in the nucleus . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| TNF dependent recruitment of the protein kinase RIP to the TNF receptor 1 signaling complex . ^^^ We also show that RIP is a serine threonine kinase that is recruited by TRADD to TNFR 1 in a TNF dependent process . ^^^ However , expression of the death domain of RIP Induces apoptosis , but potently inhibits NF kappa B activation by TNF . ^^^ These results suggest that distinct domains of RIP participate in the TNF signaling cascades leading to apoptosis and NF kappa B activation . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| One , MORT 1 ( also called FADD ) , binds to Fas / APO1 but not to p 55 R ; another , TRADD , binds to the p 55 TNF receptor but not to Fas / APO1 ; and the third , RIP , binds weakly to both receptors . ^^^ The regions within these proteins that are involved in binding to the receptors and the receptor regions to which they bind share a common sequence motif , that of the `` death domain . ' ' This study shows that the death domain motifs in MORT 1 , TRADD , and RIP bind effectively to each other , a mode of binding that may allow `` cross talk ' ' between the functional expression of the p 55 TNF receptor and Fas / APO1 . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Interaction of TRAF 2 with TNF R 2 and TRADD requires sequences at the C terminus of the TRAF C domain , whereas interaction with the protein kinase receptor interacting protein 5 ( RIP ) occurs via sequences at the N terminus of the TRAF C domain . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Association of the Fas / APO1 interacting protein MORT1 / FADD with the p 55 TNF receptor interacting protein TRADD , and the association of both MORT1 / FADD and TRADD with a third protein , RIP , provide potential cross talk mechanisms between Fas / APO1 and the p 55 TNF receptor . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Expression in cells of kinase deficient NIK mutants fails to stimulate NF kappaB and blocks its induction by TNF , by either of the two TNF receptors or by the receptor CD 95 ( Fas / Apo 1 ) , and by TRADD , RIP and MORT1 / FADD , which are adaptor proteins that bind to these receptors . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The cloning of members of these gene families and the identification of the protein interaction motifs found within their gene products has initiated the molecular identity of factors ( TRADD , FADD / MORT , RIP , FLICE / MACH , and TRAFs ) associated with both of the p 60 and p 80 forms of the TNF receptor and with other members of the TNF receptor superfamily . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The TNF R 1 associated death domain protein interacts with the p 55 TNF R 1 cytoplasmic domain and recruits the Fas associated death domain protein ( which directly activates the apoptotic proteases ) , the protein kinase receptor interacting protein , and TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Other TNF R 55 associated proteins like TRAF 2 and RIP , which were reported to mediate TNF R 55 mediated activation of nuclear factor kappaB , did not affect activation of A SMase . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of TNF receptors ( TNFRI and TNFRII ) and the adapter molecules , including TNFR associated death domain protein ( TRADD ) , TNFR associated factor 2 ( TRAF 2 ) , and receptor interacting protein ( RIP ) , were analyzed both at the protein level by flow cytometry or Western blotting , and at the mRNA level using quantitative PCR or Northern blotting in lymphocytes from aged and young subjects . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| No changes in the levels or molecular weights of the adaptor proteins TRADD ( TNF receptor associated death domain ) , RIP ( receptor interacting protein ) , or TRAF 2 ( TNF receptor associated factor 2 ) were caused by apoptogenic drugs . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The zinc finger protein A 20 inhibits TNF induced NF kappaB dependent gene expression by interfering with an RIP or TRAF 2 mediated transactivation signal and directly binds to a novel NF kappaB inhibiting protein ABIN . ^^^ Moreover , NF kappaB activation induced by overexpression of the TNF receptor associated proteins TNF receptor associated death domain protein ( TRADD ) , receptor interacting protein ( RIP ) , and TNF recep tor associated factor 2 ( TRAF 2 ) was also inhibited by expression of A 20 , whereas NF kappaB activation induced by overexpression of NF kappaB inducing kinase ( NIK ) or the human T cell leukemia virus type 1 ( HTLV 1 ) Tax was unaffected . ^^^ These results demonstrate that A 20 inhibits NF kappaB dependent gene expression by interfering with a novel TNF induced and RIP or TRAF 2 mediated pathway that is different from the NIK IkappaB kinase pathway and that is specifically involved in the transactivation of NF kappaB . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Cleavage of the death domain kinase RIP by caspase 8 prompts TNF induced apoptosis . ^^^ We report here that the death domain kinase RIP , a key component of the TNF signaling complex , was cleaved by Caspase 8 in TNF induced apoptosis . ^^^ We demonstrated that the cleavage of RIP resulted in the blockage of TNF induced NF kappaB activation . ^^^ Most importantly , the Caspase 8 resistant RIP mutants protected cells against TNF induced apopotosis . ^^^ These results suggest that cleavage of RIP is an important process in TNF induced apoptosis . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| RIP is induced during IL 2 driven T cell proliferation , and its inhibition reduces susceptibility to TNF dependent apoptosis . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Recruitment of the IKK signalosome to the p 55 TNF receptor : RIP and A 20 bind to NEMO ( IKKgamma ) upon receptor stimulation . ^^^ The adapter protein RIP plays a crucial role in NF kappaB activation by TNF . ^^^ Here we show that triggering of the p 55 TNF receptor induces binding of RIP to NEMO ( IKKgamma ) , a component of the 1 kappa B kinase ( IKK ) `` signalosome ' ' complex , as well as recruitment of RIP to the receptor together with the three major signalosome components , NEMO , IKK 1 and IKK 2 , and some kind of covalent modification of the recruited RIP molecules . ^^^ The findings suggest that the signaling activities of the IKK signalosome are regulated through binding of NEMO to RIP and A 20 within the p 55 TNF receptor complex . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The distinct roles of TRAF 2 and RIP in IKK activation by TNF R 1 : TRAF 2 recruits IKK to TNF R 1 while RIP mediates IKK activation . ^^^ The death domain kinase RIP and the TNF receptor associated factor 2 ( TRAF 2 ) are essential effectors in TNF signaling . ^^^ To understand the mechanism by which RIP and TRAF 2 regulate TNF induced activation of the transcription factor NF kappaB , we investigated their respective roles in TNF R 1 mediated IKK activation using both RIP / and TRAF 2 / fibroblasts . ^^^ We found that TNF R 1 mediated IKK activation requires both RIP and TRAF 2 proteins . ^^^ Although TRAF 2 or RIP can be independently recruited to the TNF R 1 complex , neither one of them alone is capable of transducing the TNF signal that leads to IKK activation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| These results indicated that the death domain kinase RIP , a key factor in TNF signaling , also plays a pivotal role in TRAIL induced IKK and JNK activation . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Using TRAF 2 ( / ) cells , we demonstrated that the TNF induced interaction between IKKgamma and the death domain kinase RIP is TRAF 2 dependent and that one possible function of this interaction is to stabilize the IKK complex when it interacts with TRAF2 . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The latter also inhibits NF kappaB activation induced by overexpression of receptor interacting protein or TNF receptor associated factor 2 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Moreover , overexpression of CSN 3 also inhibits NF kappaB activation triggered by proteins involved in TNF signaling , including TNF R 1 , TRAF 2 , RIP , and NIK , but not by TRAF 6 , a protein involved in IL 1 signaling . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| We have shown that MEKK 3 is required for IKK activation and functions downstream of receptor interacting protein ( RIP ) and TNF receptor associated factor 2 . ^^^ The kinase activity of MEKK 3 is pivotal to its function and , therefore , MEKK 3 links RIP and IKK in TNF induced NF kappaB activation . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Receptor interacting protein , an obligatory component of TNF alpha induced NF kappaB activation , was cleaved during TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Expression of TNFalpha signaling molecules , TNF receptor 55 and receptor interacting protein , was increased in liver and kidney after FB ( 1 ) treatment . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| PAN 2 also suppressed NF kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in the TNF or IL 1 receptor signal transduction , including TRAF 2 , TRAF 6 , RIP , IRAK 2 , and NF kappaB inducing kinase as well as the IkappaB kinases IKKalpha and IKKbeta . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Furthermore , IL 12 induced apoptosis was associated with caspase 3 , caspase 2 , caspase 7 , DNA fragmentation factor 45 ( DFF 45 ) and Fas associated death domain ( FADD ) whereas TNF receptor associated death domain ( TRADD ) and receptor interacting protein ( RIP ) were not . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| In cells deficient for RIP ( receptor interactive protein ) , an essential signaling intermediate of TNF dependent NF kappaB activation , TNF , but not PMA induced up regulation of TRAF 4 was blocked . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , although diabetes was evident in the F 1 intercross expressing rat insulin promoter ( RIP ) TNF , offspring lacking either endogenous or transgenic class 2 molecules developed accelerated diabetes with high frequency in both sexes . ^^^ RIP TNF mice can occur independent of inheritance of NOD derived idd1 . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of mRNA for TNF receptors ( TNFR ) , including TNFRI and TNFRII , and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase ( RT ) PCR in bone marrow samples from control , MDS and AML cases . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Endogenous TRAF 1 and the overexpressed TRAF domain of TRAF 1 were found to be constitutively associated with the IKK complex , whereas endogenous receptor interacting protein was only transiently associated with the IKK complex upon TNF stimulation . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| TRADD also binds two other adaptors receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) , which are required for TNF induced NF kappaB and c Jun N terminal kinase activation , respectively . ^^^ Analysis of the native TNF signaling complex revealed the recruitment of RIP , TRADD , and TRAF 2 but not FADD or caspase 8 . ^^^ In an in vitro binding assay , the intracellular domain of TNF R 1 bound TRADD , RIP , and TRAF 2 but did not bind FADD or caspase 8 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The death domain kinase RIP ( receptor interacting protein ) is an important effector of tumour necrosis factor ( TNF ) signalling and is essential for TNF induced nuclear factor kappaB activation . ^^^ However , the function of RIP in the TNF induced activation of mitogen activated protein kinases ( MAPKs ) has not been fully investigated . ^^^ In this report , using Rip null ( Rip ( / ) ) mouse fibroblast cells , we investigated whether RIP is required for TNF induced activation of the MAPKs extracellular signal related kinase ( ERK ) , p 38 and c Jun amino terminal kinase ( JNK ) . ^^^ We found that TNF induced activation of ERK , p 38 and JNK is decreased in Rip ( / ) cells . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The first complex ( complex 1 ) is formed at the membrane by TNF R 1 , TRADD , RIP , TRAF 2 and c IAP 1 , while the second complex ( complex 2 ) , formed in the cytosol , predominantly contains FADD and pro caspases 8 / 10 but lacks TNF R 1 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Regulation of cell growth and activation of NF kappaB and of c jun N terminal kinase by the TNF super family is mediated through sequential activation / association of a set of cell signaling proteins named TNF receptor associated factors , Fas associated death domain and FADD like ICE , caspases , receptor interacting protein , NF kappaB inducing kinases , and IkappaBalpha kinases . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Although , RIP is best known for its role in TNF signalling and NF kappaB activation , it contains a death domain and it is capable of causing apoptosis upon cleavage . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Inhibition of either delta PKC or PI 3 kinase decreased TNF mediated recruitment of RIP and TRAF 2 to TNFR 1 . ^^^ Thus delta PKC and PI 3 kinase are positive regulators of TNF mediated association of TRAF 2 and RIP with TNFR 1 . ^^^ These results suggest that delta PKC and PI 3 kinase regulate TNF antiapoptotic signaling at the level of the TNFR 1 through control of assembly of a TNFR 1 TRADD RIP TRAF 2 complex . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The amino terminal domain of A 20 , which is a de ubiquitinating ( DUB ) enzyme of the OTU ( ovarian tumour ) family , removes lysine 63 ( K 63 ) linked ubiquitin chains from receptor interacting protein ( RIP ) , an essential mediator of the proximal TNF receptor 1 ( TNFR 1 ) signalling complex . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| TNF binding induces release of AIP 1 from TNFR 1 , resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD , RIP 1 , TRAF 2 , and AIPl . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| These death responsive cells show prolonged TNF stimulation of c Jun N terminal kinase and p 38 mitogen activated protein kinase , but no NF kappaB transcriptional activity as a consequence of receptor interacting protein degradation by caspases . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Analyzing cell lines expressing an internalization deficient receptor ( TNF R 1 DeltaTRID ) revealed that recruitment of RIP 1 and TRAF 2 to TNF R 1 occurred at the level of the plasma membrane . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Cleavage and degradation of TNF pathway components TNFR 1 , RIP , and Hsp 90 were observed in l mimosine and H ( 2 ) O ( 2 ) treated cells indicating a putative mechanism for selective inhibition of TNF but not IL 1beta induced IKK activation . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| In the normal rat cortex , a portion of TNFR 1 was present in lipid raft microdomains , where it associated with the adaptor proteins TRADD ( TNF receptor associated death domain ) , TNF receptor associated factor 2 ( TRAF 2 ) , the Ser / Thr kinase RIP ( receptor interacting protein ) , TRAF 1 , and cIAP 1 ( cellular inhibitor of apoptosis protein 1 ) , forming a survival signaling complex . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| In contrast , transiently expressed Zfra could enhance or inhibit the cytotoxicity of overexpressed death domain proteins TRADD , FADD , and RIP of the TNF signaling pathway . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| A 20 was shown to exert two opposing activities : sequential de ubiquitination and ubiquitination of the TNF receptor interacting protein ( RIP ) , thereby targeting RIP to proteasomal degradation . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Several proteins , including FADD , the death domain kinase RIP and the TNF receptor associated factor TRAF 2 have been identified as the key effectors of TNF signaling . ^^^ Recently , we found that the effector molecules of TNF signaling , such as RIP and TRAF 2 , are also involved in other cellular responses . ^^^ These finding suggests that RIP and TRAF 2 serve a broader role than as just an effector of TNF signaling . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Monarch 1 reduces NFkappaB activation by TLR signaling molecules MyD 88 , IRAK 1 ( type 1 interleukin 1 receptor associated protein kinase ) , and TRAF 6 ( TNF receptor ( TNFR ) associated factor ) as well as TNFR signaling molecules TRAF 2 and RIP 1 but not the downstream NFkappaB subunit p 65 . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The secondary complex retained the DISC components FADD and caspase 8 , but recruited several factors involved in kinase activation by TNF , namely , RIP 1 , TRAF 2 , and NEMO / IKKgamma . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Since we observed that MC 160 decreased other NF kappaB activation pathways , namely those activated by receptor interacting protein , TNF receptor associated factor 2 , NF kappaB inducing kinase , or MyD 88 , we hypothesized that the MC 160 product interfered with 1 kappa kinase ( IKK ) activation , an event common to multiple signal transduction pathways . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Previous studies suggest that heat shock protein 90 ( Hsp 90 ) regulates the stability and function of receptor interaction proteins ( RIP ) and IkappaB kinase beta ( IKKbeta ) , the key components of the TNF induced NF kappaB activation pathway . ^^^ Treatment with 17AAG caused degradation of RIP and IKKbeta that , in turn , blocked TNF induced NF kappaB activation and antiapoptotic gene expression . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| RIP death domain structural interactions implicated in TNF mediated proliferation and survival . ^^^ Modeling of six homotypic DD interactions involved in the TNF signaling pathway implicates that the DD of RIP ( Receptor interacting protein kinase 1 ) is capable of interacting with the DD of TRADD ( TNFR 1 associated death domain protein ) in two different , exclusive ways : one that subsequently recruits CRADD ( apoptosis / inflammation ) and another that recruits NFkappaB ( survival / proliferation ) . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Here , we show that NEMO binds to Lys 63 but not Lys 48 linked polyubiquitin , and that single point mutations in NEMO that prevent binding to Lys 63 linked polyubiquitin also abrogates the binding of NEMO to RIP in tumour necrosis factor ( TNF ) alpha stimulated cells , the recruitment of IKK to TNF receptor ( TNF R ) 1 , and the activation of IKK and NF kappaB . ^^^ RIP is also destabilized in the absence of NEMO binding and undergoes proteasomal degradation in TNF alpha treated cells . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Recruitment of the NF kappaB activating IKK signaling complex to the TNF receptor is shown to be driven by induced binding of NEMO , a regulatory component of this complex , to K 63 linked polyubiquitin chains attached to RIP 1 , a receptor associated adaptor protein ( Ea et al . , 2006 [ in a recent issue of Molecular Cell ] ; Li et al . , 2006 ; Wu et al . , 2006a ) . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Together , these results demonstrate that the interaction of p 62 with RIP serves to link the atypical PKCs to the activation of NF kappaB by the TNFalpha signaling pathway . . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Transcriptional expression of TNFR 1 ( p 55 ) , as well as that of FLICE , Fas , FADD , DR 3 , FAF , TRADD , and RIP was similar in these cell lines , indicating that the susceptibility to TNFalpha induced apoptosis may not be determined by the constitutive expression level of these factors . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| However , expression of the adaptor protein RIP , which is essential for IKK activation by TNFalpha , was decreased in cells exposed to H2O2 , and its chaperone Hsp 90 was cleaved . ^^^ |
|
| Interacting proteins: P01375 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The combination of z VAD fmk and TNFalpha , but not TNFalpha alone , induced SMCs necrosis via a mechanism that required RIP 1 expression . ^^^ |
|