| Interacting proteins: Q13546 and P00533 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor receptor engages receptor interacting protein and nuclear factor kappa B ( NF kappa B ) inducing kinase to activate NF kappa B . ^^^ We show the EGFR forms a complex with a TNFR interacting protein ( RIP ) , which plays a key role in TNFR induced NF kappaB activation , but not with TRADD , an adaptor protein which serves to recruit RIP to the TNFR . ^^^ Furthermore , we show that the EGFR associates with NF kappaB inducing kinase ( NIK ) and provide evidence suggesting multiprotein complex formation between the EGFR , RIP , and NIK . ^^^ |
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| Interacting proteins: Q13546 and P00533 |
Pubmed |
SVM Score :0.0 |
| Rhabdomyosarcoma cells were treated with indirect immunotoxins consisting in primary specific murine monoclonal antibodies recognizing EGF R , HER 2 and HER 3 followed by secondary F ( ab ' ) 2 antimouse immunoglobulin linked to saporin S 6 , a type 1 ribosome inactivating protein ( RIP ) from the seeds of Saponaria officinalis . ^^^ |
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| Interacting proteins: Q13546 and P00533 |
Pubmed |
SVM Score :0.0 |
| Hence , Schwann cell derived factors compromise inhibitory signalling by ( 1 ) antagonizing ligand / NgR binding with metalloproteinase cleaved Nogo A peptides ; ( 2 ) RIP of p75NTR ; ( 3 ) competitively blocking NgR / p75NTR clustering with soluble p75ECD ; and ( 4 ) consequent reduced downstream EGFR phosphorylation and suppression of Rho A activation . ^^^ Moreover , in RGC cultures , exogenous tumour necrosis converting enzyme ( TACE ) initiates RIP of p75NTR , reduces EGFR phosphorylation , suppresses activation of Rho A , cleaves the ECD from both NgR and TROY , and disinhibits neurotrophic factor ( NTF ) stimulated RGC neurite outgrowth in the presence of CNS myelin . ^^^ |
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| Interacting proteins: Q13546 and P00533 |
Pubmed |
SVM Score :0.0 |
| A common denominator of ADAM mediated proteolysis is the ectodomain shedding of a broad spectrum of substrates , including paracrine growth factors like epidermal growth factor receptor ( EGFR ) ligands , cell adhesion molecules like CD 44 or cadherins , and the initiation of regulated intramembrane proteolysis ( RIP ) , whereby the transmembrane fragment of the respective substrate is further cleaved by an intramembrane cleaving protease to release an intracellular domain acting as a nuclear transcription regulator . ^^^ |
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| Interacting proteins: Q13546 and P00533 |
Pubmed |
SVM Score :0.0 |
| After addition of TACE ( which has alpha secretase activity ) to mitotically arrested adult rat mixed DRG cultures , we demonstrate 1 ) NgR ( ECD ) shedding ; 2 ) release of p 75 ( ECD ) and p 75 ( ICD ) by RIP of p 75 ( NTR ) ; 3 ) blockade of Rho A activation ; 4 ) reduced EGFR phosphorylation ; and 5 ) increased FGF 2 stimulated DRGN neurite outgrowth and branching in the presence of CNS myelin derived inhibitory ligands . ^^^ |
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| Interacting proteins: Q13546 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13546 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13546 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
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