| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.7346537 |
| Fas recruited FLIP interacts with TNF receptor associated factors 1 and 2 , as well as with the kinases RIP and Raf 1 , resulting in the activation of the NF kappaB and extracellular signal regulated kinase ( Erk ) signaling pathways . 0.7346537^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| CARD 6 associates with microtubules and interacts with receptor interacting protein ( RIP ) like interacting caspase like apoptosis regulatory protein kinase ( RICK ) , a CARD containing member of the RIP family of protein kinases . ^^^ |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Examples of prominent CARD proteins are caspase 9 and Apaf 1 , which are involved in the intrinsic death pathway ; BCL 10 and CARD 11 , which mediate antigen receptor induced NF kappaB activation ; and receptor interacting protein ( RIP ) like interacting caspase like apoptosis regulatory protein kinase ( RICK ) and the nucleotide binding oligomerization domain ( NOD ) proteins , which induce NF kappaB activation in response to intracellular bacterial peptidoglycan . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| A dominant negative mutant of RIP inhibits FADD and caspase 8 induced but not Casper induced NF kappaB activation . ^^^ |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Both cell lines express almost the same levels of FADD , RIP , c FLIP , FAP 1 , Bax , Bcl 2 and Bcl XL . ^^^ |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Ligation of CD 95 instigates the formation of a complex known as the `` death inducing signaling complex ' ' or DISC , which is composed of molecules including FADD ( Fas associated with death domain ) and RIP ( receptor interacting kinase ) , as well as procaspases 8 and 10 , and a caspase 8 like molecule that lacks proteolytic activity called c FLIP . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Both caspase 8 and caspase 3 were partially activated in effector T cells , which was reflected in cleavage of the caspase 8 substrates , c FLIP ( L ) , receptor interacting protein 1 , and to a lesser extent Bid , but not the caspase 3 substrate inhibitor of caspase activated DNase . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Subsequently , additional functions of c FLIP ( L ) were identified through its association with receptor interacting protein ( RIP ) 1 and TNFR associated factor 2 to activate NF kappaB , as well as by its association with and activation of caspase 8 . ^^^ Both augmented proliferation and CD 25 expression are blocked by caspase inhibition . c FLIP ( L ) itself is a substrate of the caspase activity in effector T cells , being cleaved to a p 43 ( FLIP ) form . p 43 ( FLIP ) more efficiently recruits RIP 1 than full length c FLIP ( L ) to activate NF kappaB . c FLIP ( L ) and RIP 1 also coimmunoprecipitate with active caspase 8 in effector CD 8 ( + ) T cells . ^^^ Thus , one mechanism by which c FLIP ( L ) influences effector T cell function is through its activation of caspase 8 , which in turn cleaves c FLIP ( L ) to allow RIP 1 recruitment and NF kappaB activation . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| This occurs coincidently with the cleavage of two known caspase 8 substrates , c FLIP ( L ) and receptor interacting protein 1 . ^^^ |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The protein levels of caspase 3 , 8 , and 9 , DFF 45 ( DNA fragmentation factor 45 ) , and FLIP ( Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme inhibitory proteins ) were decreased , whereas those of ARC ( apoptosis repressor with caspase recruitment domain ) and RICK ( Receptor interacting protein ( RIP ) like interacting CLARP kinase ) increased in AD . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Furthermore , FADD , RIP , and FLIP were also expressed by subsets of dissociated cortical neuroblasts in culture . ^^^ |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Here , we report that metabolic inhibitors such as cycloheximide ( CHX ) or actinomycin D ( ActD ) sensitize for CD 95 induced apoptosis by strongly down regulating FLIP and RIP expression . ^^^ In contrast to Fas associated death domain ( FADD ) or caspase 8 , FADD like interleukin 1 converting enzyme inhibitory protein ( FLIP ) and RIP protein levels rapidly decreased upon treatment with CHX or ActD , indicating that both molecules have a high turnover rate . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| FasL , Fas , FADD , RIP , caspase 8 , caspase 3 , Bid , FLIP ( S+L ) , FLASH and FAP 1 , proteins known to act within the Fas apoptosis cascade , showed no changes in their expression levels in cells treated with butyrate compared with untreated cells . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Sensitization of PSC with culture duration was accompanied by increased expression of CD 95 and TRAIL receptor 2 and no alterations of Flip expression or protein kinase B phosphorylation but was paralleled by the appearance of a COOH terminal cleavage product of receptor interacting protein . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| TRAIL receptors 1 and 2 , FLIP ( caspase 8 inhibitory protein ) , and receptor interacting protein were up regulated during hepatic stellate cell transformation ; however , TRAIL addition did not induce hepatic stellate cell death . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| Moreover , FLIP ( L ) expression favors receptor interacting kinase ( RIP ) processing within the Fas signaling complex . ^^^ We propose that FLIP ( L ) inhibits caspase 8 release dependent pro apoptotic signals , whereas the single , membrane restricted active site of the FLIP ( L ) caspase 8 heterocomplex is proteolytically active and acts on local substrates such as RIP . . ^^^ |
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| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| A novel anti apoptotic mechanism of FLIP in the recruitment of RIP and TRAF 1 and TRAF 2 to activate ERK and NF kappaB has been defined . ^^^ |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| The role of CD 25 , CD 28 and the intracellular proteins , FLICE inhibitory protein ( FLIP ) , receptor interacting protein ( RIP ) and caspase 3 were investigated . ^^^ Expression levels of full length RIP and FLIP did not show any correlation to apoptotic susceptibility . ^^^ |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NFkappaB activation by Fas is mediated through FADD , caspase 8 , and RIP and is inhibited by FLIP . ^^^ |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13546 |
Pubmed |
SVM Score :0.0 |
| NA |
|