| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.5531586 |
| Metaxin 1 interacts with metaxin 2 , a novel related protein associated with the mammalian mitochondrial outer membrane . 0.5531586^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| In comparison , the cDNA of 10 . laevis metaxin 1 ( XMTX 1 ) specifies a protein of 320 residues , while the metaxin 2 cDNAs of 10 . laevis ( XMTX 2 ) and 10 . tropicalis ( SMTX 2 ) both specify proteins of 274 amino acids . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| They are MEX 1 , MIX 1 , MTX 1 , MTX 2 , MTX 3 and MTX 4 . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| The so called muscarinic toxins ( MTX 1 and MTX 2 ) have been shown to inhibit the specific binding of [ 3H ] QNB ( 0 . 15 nM ) , [ 3H ] PZ ( 2 . 5 nM ) and [ 3H ] oxoM ( 2 nM ) to bovine cerebral cortex membranes by 60 , 88 and 82 % respectively . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| MTX 2 or 4 mg kg 1 ( MTX 2 or 4 mg ) + / INDO in general partly restored ( increased ) the amounts of tumour FAs , and reduced the saturated / unsaturated FA ratio . ^^^ In the ' normal ' spleen and plasma also , but not in the liver , MTX 2 mg generally somewhat restored the FA composition . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| Binding of muscarinic toxins MTx 1 and MTx 2 from the venom of the green mamba Dendroaspis angusticeps to cloned human muscarinic cholinoceptors . ^^^ Muscarinic toxins MTx 1 and MTx 2 are 7500 mol . wt polypeptides isolated from the venom of the green mamba snake Dendroaspis angusticeps . ^^^ The present work was undertaken in order to clarify the muscarinic subtype specificity and functional effects of MTx 1 and MTx 2 . ^^^ MTx 1 and MTx 2 inhibited 3H NMS binding to m 1 and m 3 receptors , with little effect on binding to m 2 and m 4 receptors . ^^^ Affinity was higher for m 1 receptors : Ki for MTx 1 were 48 nM at m 1 receptors and 72 nM at m 3 receptors , and Ki for MTx 2 were 364 nM at m 1 and 1 . 2 microM at m 3 receptors . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| Four different protocols of MTX ( Ledertrexate ) administration was performed in this series with time : at the beginning of our experience , MTX 1 protocol , 15 mg i . m . daily for 5 days was used ; and after MTX 2 protocol , 1 mg / kg body weight i . m . daily for 4 days ; MTX 3 protocol , 1 mg / kg body weight intratubal associated with 1 mg / kg body weight i . m . daily for 3 days ; and now MTX 4 protocol , only intratubal 1 mg / kg body weight is especially used . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| The numbers of drop outs due to toxicity were SSZ 9 , MTX 2 , COMBI 5 . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| We report the isolation of two novel zebrafish mix type homeobox genes , mtx 1 and mtx 2 . ^^^ The homeodomains of both Mtx 1 and Mtx 2 exhibited a 50 % amino acid identity to other Mix family protein homeodomains . mtx 1 was expressed throughout the yolk syncytial layer ( YSL ) , an extraembryonic structure in teleosts , from the late blastula to the mid gastrula period . mtx 2 was first expressed in the dorsal blastomeres soon after the mid blastula transition , and slightly later in the entire blastoderm margin . ^^^ The expression of mtx 2 was dependent on Wnt signals but not on Nodal signals . mtx 1 expression was not regulated by either Wnt or Nodal signals . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| When the MTX and 5 FU concentrations are 10 microM , antiproliferative effects of MTX 2 hr before 5 FU ( MTX / 5 FU ) and 5 FU 2 h before MTX ( 5 FU / MTX ) are 25 . 17+ / 1 . 23 % and 25 . 60+ / 1 . 28 % of the control rate , respectively . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| The zebrafish metaxin genes are designated mtx 1 , mtx 2 and mtx 3 , following zebrafish nomenclature guidelines . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| The combinations of 5 FU 2 h prior to MTX or MTX 2 h prior to 5 FU followed by a 48 h incubation , respectively , gave growth rates of 20 . 96 + / 2 . 44 % and 19 . 86 + / 2 . 56 % of the control rate for MCF 7 cells . ^^^ In bone marrow cells , the combinations of 5 FU 2 h prior to MTX or MTX 2 h prior to 5 FU followed by a 48 h incubation , respectively , gave growth rates of 79 . 66 + / 7 . 41 % ( protection ) and 31 . 39 + / 1 . 77 % of the control rate . ^^^ |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75431 and Q13505 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.5531586 |
| Metaxin 1 interacts with metaxin 2 , a novel related protein associated with the mammalian mitochondrial outer membrane . 0.5531586^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| Four different protocols of MTX ( Ledertrexate ) administration was performed in this series with time : at the beginning of our experience , MTX 1 protocol , 15 mg i . m . daily for 5 days was used ; and after MTX 2 protocol , 1 mg / kg body weight i . m . daily for 4 days ; MTX 3 protocol , 1 mg / kg body weight intratubal associated with 1 mg / kg body weight i . m . daily for 3 days ; and now MTX 4 protocol , only intratubal 1 mg / kg body weight is especially used . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| The numbers of drop outs due to toxicity were SSZ 9 , MTX 2 , COMBI 5 . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| The combinations of 5 FU 2 h prior to MTX or MTX 2 h prior to 5 FU followed by a 48 h incubation , respectively , gave growth rates of 20 . 96 + / 2 . 44 % and 19 . 86 + / 2 . 56 % of the control rate for MCF 7 cells . ^^^ In bone marrow cells , the combinations of 5 FU 2 h prior to MTX or MTX 2 h prior to 5 FU followed by a 48 h incubation , respectively , gave growth rates of 79 . 66 + / 7 . 41 % ( protection ) and 31 . 39 + / 1 . 77 % of the control rate . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| When the MTX and 5 FU concentrations are 10 microM , antiproliferative effects of MTX 2 hr before 5 FU ( MTX / 5 FU ) and 5 FU 2 h before MTX ( 5 FU / MTX ) are 25 . 17+ / 1 . 23 % and 25 . 60+ / 1 . 28 % of the control rate , respectively . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| They are MEX 1 , MIX 1 , MTX 1 , MTX 2 , MTX 3 and MTX 4 . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| In comparison , the cDNA of 10 . laevis metaxin 1 ( XMTX 1 ) specifies a protein of 320 residues , while the metaxin 2 cDNAs of 10 . laevis ( XMTX 2 ) and 10 . tropicalis ( SMTX 2 ) both specify proteins of 274 amino acids . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| MTX 2 or 4 mg kg 1 ( MTX 2 or 4 mg ) + / INDO in general partly restored ( increased ) the amounts of tumour FAs , and reduced the saturated / unsaturated FA ratio . ^^^ In the ' normal ' spleen and plasma also , but not in the liver , MTX 2 mg generally somewhat restored the FA composition . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| We report the isolation of two novel zebrafish mix type homeobox genes , mtx 1 and mtx 2 . ^^^ The homeodomains of both Mtx 1 and Mtx 2 exhibited a 50 % amino acid identity to other Mix family protein homeodomains . mtx 1 was expressed throughout the yolk syncytial layer ( YSL ) , an extraembryonic structure in teleosts , from the late blastula to the mid gastrula period . mtx 2 was first expressed in the dorsal blastomeres soon after the mid blastula transition , and slightly later in the entire blastoderm margin . ^^^ The expression of mtx 2 was dependent on Wnt signals but not on Nodal signals . mtx 1 expression was not regulated by either Wnt or Nodal signals . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| The zebrafish metaxin genes are designated mtx 1 , mtx 2 and mtx 3 , following zebrafish nomenclature guidelines . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| The so called muscarinic toxins ( MTX 1 and MTX 2 ) have been shown to inhibit the specific binding of [ 3H ] QNB ( 0 . 15 nM ) , [ 3H ] PZ ( 2 . 5 nM ) and [ 3H ] oxoM ( 2 nM ) to bovine cerebral cortex membranes by 60 , 88 and 82 % respectively . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| Binding of muscarinic toxins MTx 1 and MTx 2 from the venom of the green mamba Dendroaspis angusticeps to cloned human muscarinic cholinoceptors . ^^^ Muscarinic toxins MTx 1 and MTx 2 are 7500 mol . wt polypeptides isolated from the venom of the green mamba snake Dendroaspis angusticeps . ^^^ The present work was undertaken in order to clarify the muscarinic subtype specificity and functional effects of MTx 1 and MTx 2 . ^^^ MTx 1 and MTx 2 inhibited 3H NMS binding to m 1 and m 3 receptors , with little effect on binding to m 2 and m 4 receptors . ^^^ Affinity was higher for m 1 receptors : Ki for MTx 1 were 48 nM at m 1 receptors and 72 nM at m 3 receptors , and Ki for MTx 2 were 364 nM at m 1 and 1 . 2 microM at m 3 receptors . ^^^ |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13505 and O75431 |
Pubmed |
SVM Score :0.0 |
| NA |
|