| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| SN 50 induced apoptosis in MM cell lines and patient cells ; down regulated expression of Bcl 2 , A 1 , 10 chromosome linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein 1 ( cIAP 1 ) , cIAP 2 , and survivin ; up regulated Bax ; increased mitochondrial cytochrome c release into the cytoplasm ; and activated caspase 9 and caspase 3 , but not caspase 8 . ^^^ |
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| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Similarly to XIAP , in vitro binding experiments indicated that c IAP 1 and c IAP 2 bound specifically to the terminal effector cell death proteases , caspases 3 and 7 , but not to the proximal protease caspase 8 , caspases 1 or 6 . ^^^ |
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| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NF kappaB antiapoptosis : induction of TRAF 1 and TRAF 2 and c IAP 1 and c IAP 2 to suppress caspase 8 activation . ^^^ |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Also , treatment of cells with kamebakaurin prevented the tumor necrosis factor alpha ( TNF alpha ) induced expression of antiapoptotic NF kappaB target genes encoding c IAP 1 ( hiap 2 ) and c IAP 2 ( hiap 1 ) , members of the inhibitor of apoptosis family , and Bfl 1 / A1 , a prosurvival Bcl 2 homologue , and augmented the TNF alpha induced caspase 8 activity , thereby resulting in sensitizing MCF 7 cells to TNF alpha induced apoptosis . ^^^ |
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| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Overexpression of RelA subunit inhibits caspase 8 and DR 4 and DR 5 expression and enhances expression of cIAP 1 and c IAP 2 after TRAIL treatment . ^^^ |
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| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Lastly , TRAIL / Apo2L induced apoptosis in MM cells was dependent on caspase 8 activation and inhibited by the caspase regulatory proteins FLIP and cIAP 2 . ^^^ |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , other proteins analyzed [ namely , Apaf 1 , Bax , Bid , caspase 3 , caspase 8 , caspase 9 , 10 linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein ( cIAP ) 1 , cIAP 2 , cytochrome c , Fas , Fas ligand , FLIP , p 53 , and poly ( ADP ribose ) polymerase ] were not affected by either rituximab or cisplatin . ^^^ |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Our data set a framework for the clinical use of approaches that sensitize MM cells to TRAIL by agents that inhibit FLIP and cIAP 2 expression or augment caspase 8 activity . . ^^^ |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Upon inhibition of caspase 8 , overexpression of par 4 enables Jurkat cells to maintain a higher sensitivity to CD 95 induced apoptosis by downregulating cIAP 2 and XIAP and by enforcing activation of the initiator caspase 10 as well as of the executioner caspases 6 , 7 , and 3 . . ^^^ |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|