| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.7037733 |
| Cellular inhibitor of apoptosis protein 1 ( c IAP 1 ) can regulate apoptosis through its interaction with downstream TNF receptor effectors ( TRAF 1 and TRAF 2 ) , by binding to and inhibiting certain caspases , and by controlling the levels of specific proapoptotic stimuli ( e . g . , Smac / DIABLO ) within the cell . 0.7037733^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Alteration of the transcription of anti apoptotic proteins , including inhibitor of apoptosis protein 1 , 2 ( cIAP 1 , 2 ) , TNF receptor associated factor 1 ( TRAF 1 ) , nuclear factor kappa B 1 protein ( NFkappaB 1 ) , and FLICE inhibitory protein ( FLIP ) was assessed by real time reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In the normal rat cortex , a portion of TNFR 1 was present in lipid raft microdomains , where it associated with the adaptor proteins TRADD ( TNF receptor associated death domain ) , TNF receptor associated factor 2 ( TRAF 2 ) , the Ser / Thr kinase RIP ( receptor interacting protein ) , TRAF 1 , and cIAP 1 ( cellular inhibitor of apoptosis protein 1 ) , forming a survival signaling complex . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The NF kappaB regulated gene products cyclin D 1 , cyclooxygenase 2 ( COX 2 ) , matrix metalloproteinase 9 ( MMP 9 ) , survivin , inhibitor of apoptosis protein 1 ( IAP 1 ) , IAP 2 , 10 chromosome linked IAP ( XIAP ) , Bcl 2 , Bfl 1 / A1 , TNF receptor associated factor 1 ( TRAF 1 ) , and Fas associated death domain protein like interleukin 1beta converting enzyme inhibitory protein ( FLIP ) were all down regulated by indole 3 carbinol . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NF kappaB antiapoptosis : induction of TRAF 1 and TRAF 2 and c IAP 1 and c IAP 2 to suppress caspase 8 activation . ^^^ TRAF 1 ( TNFR associated factor 1 ) , TRAF 2 , and the inhibitor of apoptosis ( IAP ) proteins c IAP 1 and c IAP 2 were identified as gene targets of NF kappaB transcriptional activity . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In normal tissue , expression of the known NF kappaB regulated antiapoptotic factors , TRAF 1 , TRAF 2 , c IAP 1 , and c IAP 2 , is most pronounced in outer epidermis . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| A RNase protection analysis showed that PMA stimulated the expression of several known anti apoptotic genes ( TRAF 1 , TRAF 4 , c IAP 1 , c IAP 2 , Bfl 1 , Bcl xl ) . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Furthermore , arsenic treatment down regulated NF kappaB target genes , including tumor necrosis factor alphareceptor associated factor 1 ( TRAF 1 ) , c IAP 2 , interleukin 13 ( IL 13 ) , and CCR 7 . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Quantitative real time PCR demonstrated that AS 602868 prevented TNF alpha induction of the antiapoptotic genes coding for c IAP 2 , Bclx , Bfl 1 / A1 and Traf 1 . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Multiple survival factor genes , including cellular inhibitor of apoptosis protein ( c IAP 1 ) , c IAP 2 , TNF receptor associated factor 1 ( TRAF 1 ) , TRAF 2 , B cell leukemia / lymphoma 2 ( Bcl 2 ) , Bcl 10 , A 1 , and cellular Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme like inhibitory protein ( c FLIP ) , were expressed in basal conditions in both cultured RPE cells and RPE cells in situ , whereas survivin was expressed only by cultured cells . ^^^ TNF alpha upregulated expression of TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 . ^^^ TRAF 1 , c FLIP , and to a lesser extent c IAP 2 protein levels were increased by TNF alpha in a time dependent manner , whereas c IAP 1 , survivin , Bcl 10 ( L ) , and TRAF 2 protein levels were not influenced by TNF alpha treatment at any time point tested . ^^^ Overexpression of mutant IkappaB blocked TNF alpha induced TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 gene expression and downregulated TRAF 1 protein levels . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In addition , SB 203580 selectively reduced CD 40 induced CD54 / ICAM 1 expression , whereas CD 40 dependent expression of CD 40 and CD95 / Fas and four newly defined CD 40 responsive genes cIAP 2 , TRAF 1 , TRAF4 / CART and DR 3 were unaffected . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| All transfectants showed a reduced sensitivity to tumor necrosis factor ( TNF ) induced apoptosis , which correlated with the amount of transgene expressed and with an enhanced basal transcription rate of NF kappaB driven genes including the inhibitor of apoptosis protein 2 ( cIAP 2 ) and TNF receptor associated protein 1 ( TRAF 1 ) . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor alpha induced lung cell expression of antiapoptotic genes TRAF 1 and cIAP 2 . ^^^ Tumor necrosis factor ( TNF ) receptor ( TNFR ) associated factors 1 and 2 ( TRAF 1 and TRAF 2 ) and inhibitor of apoptosis proteins cIAP 1 ( MIHB ) and cIAP 2 ( MIHC ) were recently identified as proteins that associate with the TNF alpha receptors TNFRI ( p 55 ) and TNFRII ( p 75 ) and inhibit TNF alpha induced programmed cell death or apoptosis . ^^^ These studies support the hypothesis that the TRAF 1 and cIAP 2 genes are highly regulated in pulmonary cells and may play a role in human lung disease . . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Under these conditions , TRAIL and anti APO 1 up regulated the expression of the known NF kappaB targets interleukin 6 , cellular inhibitor of apoptosis 2 ( cIAP 2 ) , and TRAF 1 ( TRAF , tumor necrosis factor receptor associate factor ) . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis further revealed that cFLIP , but not TRAF 1 , A 20 , and cIAP 2 , expression levels rapidly decrease upon CHX treatment . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In this report , we have shown that cIAP 2 specifically mediated ubiquitination and proteasome dependent degradation of TRAF 1 . ^^^ To identify the sites for cIAP 2 mediated ubiquitination of TRAF 1 , we used high pressure liquid chromatography coupled with tandem mass spectrometry . ^^^ Mutation of Lys 185 and Lys 193 to Arg almost completely blocked cIAP 2 mediated ubiquitination of TRAF 1 , indicating that they are the major , if not the only , sites of TRAF 1 ubiquitination . ^^^ Our data suggest that cIAP 2 may regulate the turnover of TRAF 1 by adding polyubiquitin chains on Lys 185 or Lys 193 following its recruitment to TNF R signaling complexes . . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| RESULTS : MCF 7 cells overexpressing Bcl xL but not TRAF 1 , cIAP 2 or Mn SOD were less sensitive to both paclitaxel and docetaxel compared to vector transfected control cells . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The ability of IL 18 to regulate cell survival is not limited to a caspase death pathway in that IL 18 augments tumor necrosis factor ( TNF ) signaling , resulting in increased and prolonged mRNA expression of c apoptosis inhibitor 2 ( cIAP 2 ) , a prosurvival factor and caspase 3 inhibitor , and TNF receptor associated factor 1 ( TRAF 1 ) , a prosurvival protein . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| As MIHB and MIHC were able to bind to the tumor necrosis factor receptor associated factors TRAF 1 and TRAF 2 in yeast two hybrid assays , these results suggest that IAP proteins that inhibit apoptosis may do so by regulating signals required for activation of ICE like proteases . . ^^^ |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
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