| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.84301948 |
| An AIP 1 mutant with deletion of this proline rich region constitutively binds to TRAF 2 and ASK 1 . 0.84301948^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Moreover , preincubation of HUVEC with 10 ng / mL TcdB 10463 reduced TNF alpha related expression of interleukin 8 ( IL 8 ) , TNF receptor associated factor 2 ( TRAF 2 ) , and human inhibitor of apoptosis protein 1 ( hIAP 1 ) mRNA . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Cellular inhibitor of apoptosis protein 1 ( c IAP 1 ) can regulate apoptosis through its interaction with downstream TNF receptor effectors ( TRAF 1 and TRAF 2 ) , by binding to and inhibiting certain caspases , and by controlling the levels of specific proapoptotic stimuli ( e . g . , Smac / DIABLO ) within the cell . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In the normal rat cortex , a portion of TNFR 1 was present in lipid raft microdomains , where it associated with the adaptor proteins TRADD ( TNF receptor associated death domain ) , TNF receptor associated factor 2 ( TRAF 2 ) , the Ser / Thr kinase RIP ( receptor interacting protein ) , TRAF 1 , and cIAP 1 ( cellular inhibitor of apoptosis protein 1 ) , forming a survival signaling complex . ^^^ |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| As a result , three important regulators of apoptosis , Smac , HtrA 2 , and TRAF 2 , and three other proteins were identified as potential API 2 MALT1 binding proteins . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The recruitment of c IAP 1 or c IAP 2 to the TNFR 2 signaling complex requires a TRAF 2 TRAF1 heterocomplex . . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NF kappaB antiapoptosis : induction of TRAF 1 and TRAF 2 and c IAP 1 and c IAP 2 to suppress caspase 8 activation . ^^^ TRAF 1 ( TNFR associated factor 1 ) , TRAF 2 , and the inhibitor of apoptosis ( IAP ) proteins c IAP 1 and c IAP 2 were identified as gene targets of NF kappaB transcriptional activity . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In normal tissue , expression of the known NF kappaB regulated antiapoptotic factors , TRAF 1 , TRAF 2 , c IAP 1 , and c IAP 2 , is most pronounced in outer epidermis . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Transient transfection studies with wild type and E 3 defective c IAP 1 revealed that c IAP 2 is a direct target for c IAP 1 mediated ubiquitination and subsequent degradation , which are potentiated by the adaptor function of TRAF 2 . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Multiple survival factor genes , including cellular inhibitor of apoptosis protein ( c IAP 1 ) , c IAP 2 , TNF receptor associated factor 1 ( TRAF 1 ) , TRAF 2 , B cell leukemia / lymphoma 2 ( Bcl 2 ) , Bcl 10 , A 1 , and cellular Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme like inhibitory protein ( c FLIP ) , were expressed in basal conditions in both cultured RPE cells and RPE cells in situ , whereas survivin was expressed only by cultured cells . ^^^ TNF alpha upregulated expression of TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 . ^^^ TRAF 1 , c FLIP , and to a lesser extent c IAP 2 protein levels were increased by TNF alpha in a time dependent manner , whereas c IAP 1 , survivin , Bcl 10 ( L ) , and TRAF 2 protein levels were not influenced by TNF alpha treatment at any time point tested . ^^^ Overexpression of mutant IkappaB blocked TNF alpha induced TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 gene expression and downregulated TRAF 1 protein levels . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The up regulated genes include HIAP 1 , CRAF 1 , TRAF 6 , CASP 1 , CASP 2 , CASP 3 , CASP 4 , HPRT , GADD 45 , MCL 1 , NIP 1 , BCL2L2 , TRAP 3 , GSTP 1 , DAXX , PIG 11 , UBC , PIG 3 , PCNA , CDC 10 , JNK 1 and RBP 2 . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) receptor ( TNFR ) associated factors 1 and 2 ( TRAF 1 and TRAF 2 ) and inhibitor of apoptosis proteins cIAP 1 ( MIHB ) and cIAP 2 ( MIHC ) were recently identified as proteins that associate with the TNF alpha receptors TNFRI ( p 55 ) and TNFRII ( p 75 ) and inhibit TNF alpha induced programmed cell death or apoptosis . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Thus , to investigate the molecular mechanism involved in the unresponsiveness of these cell clones to TNF alpha induced apoptosis , we examined the effect of TNF alpha on the expression of antiapoptotic proteins , including TNF receptor associated factor ( TRAF ) 1 , TRAF 2 , cellular inhibitor of apoptosis protein ( cIAP ) 1 , and cIAP 2 . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The inhibitor of apoptosis proteins cIAP 1 and cIAP 2 were also recruited by TRAF 2 to sites of CD 40 signaling . ^^^ |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| We found no induction of TRAFI , TRAF 2 , cIAPI , cIAP 2 , XIAP , A 20 or Bfl / Al in Ph+ ALL samples as compared to Ph negative ALL controls . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TRAF 2 , cIAP 1 and cIAP 2 all have RING finger domains known to possess E 3 ubiquitin ligase activity , implying that ubiquitination may play an important role in the TNF signaling pathway . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| HGF / SF induced the expression of several known NF kappaB target genes ( cIAP 1 ( cellular inhibitor of apoptosis 1 ) , cIAP 2 , and TRAF 2 ( TNF receptor associated factor 2 ) ) in an NF kappaB dependent manner ; HGF / SF blocked the inhibition of expression of these genes by ADR . ^^^ Experimental manipulation of expression of these genes suggests that they ( particularly TRAF 2 and cIAP 2 ) contribute to the protection against ADR by HGF / SF . ^^^ |
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| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| As MIHB and MIHC were able to bind to the tumor necrosis factor receptor associated factors TRAF 1 and TRAF 2 in yeast two hybrid assays , these results suggest that IAP proteins that inhibit apoptosis may do so by regulating signals required for activation of ICE like proteases . . ^^^ |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|